Research Article
Volume 11 Issue 6 - 2020
Optic Nerve Head and Retinal Nerve Fiber Layer Thickness Analysis in Healthy and Ocular Hypertensive Eyes Using Optical Coherence Tomography
Efendiyeva Matanat Elton*
National Center of Ophthalmology Named After Academy Zarifa Aliyeva, Baku, Azerbaijan
*Corresponding Author: Efendiyeva Matanat Elton, Ophthalmologist, Head of WET LAB Department at the National Center of Ophthalmology Named After Academy Zarifa Aliyeva, Baku, Azerbaijan.
Received: April 13, 2020; Published: May 15, 2020


Purpose: To assess and compare optic nerve head and retinal nerve fiber layer thickness measurements in healthy and ocular hypertension subjects using optical coherence tomography (OCT).

Material and Methods: The study enrolled 63 Caucasian patients (126 eyes) of the same Azeri ethnicity. 25 healthy people (50 eyes) and 38 patients (76 eyes) with ocular hypertension. Peripapillary RNFL assessment was performed using “RNFL Thickness Average Analysis Report” and the head analysis with “Optic Nerve Head Analysis” program, Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA). Student and Wilcoxon tests were used to statistically evaluate the results.

Results: The study revealed that considerable thinning of TRNFL (95% confidence interval) when compared to the control group was detected in the inferior quadrant by 8.2% (р ˂ 0,01) and nasal one by 9.1% (р ˂ 0,05), as well as RNFL aver - 6,4% (р ˂ 0,01) and I max - 6,4% (р ˂ 0,05). However, hourly in-depth analysis of the study group when compared to the control one showed a significant thinning of TRNFL that was greater at the nasal quadrant clock: 2:00 by 8,0%; 300 - 7,8%; 4:00 - 13,2% (р ˂ 0,01) and only at 5:00 of the inferior quadrant- 11,7% (р ˂ 0,01); the smallest shortening in TRNFL was at 12:00 - 1.6% in the superior quadrant. The study of bioretinometric indicators of ONH in the second group when compared to the control one revealed that there was a 38.6% increase in the cup area (р ˂ 0,01), cup/disk area ratio by 25,1% (р ˂ 0,05), cup/disk vertical ratio by 11,7% (р ˂ 0,05) and optic nerve disc diameter by 8.8% (р ˂ 0,05). No gender differences were found..

Keywords: Ocular Hypertension; Optical Coherence Tomography; Retinal Nerve Fiber Layer; Optic Nerve Head


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Citation: Efendiyeva Matanat Elton. “Optic Nerve Head and Retinal Nerve Fiber Layer Thickness Analysis in Healthy and Ocular Hypertensive Eyes Using Optical Coherence Tomography”. EC Ophthalmology 11.6 (2020): 19-26.

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