Research Article
Volume 11 Issue 4 - 2020
Assessment of Smooth Muscle Cell and Endothelial Functions in Branch Retinal Vein Occlusion
Sinan Bilgin1*, Ozcan Kayikcioglu2, Tansu Erakgun3 and Meral Kayikcioglu4
1Department of Ophthalmology, Medifema Hospital, Izmir, Turkey
2Department of Ophthalmology, Hafsa Sultan Hospital, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
3Ekol Eye Health Center, Izmir, Turkey
4Department of Cardiology, Ege University, Izmir, Turkey
*Corresponding Author: Sinan Bilgin, Department of Ophthalmology, Medifema Hospital, Izmir, Turkey.
Received: February 18, 2020; Published: March 16, 2020




Abstract

Purpose: One of the common retinal vascular disorder is branch retinal vein occlusion (BRVO) that causes visual impairment. The purpose of this study is to evaluate vascular smooth muscle cell and endothelial functions in BRVO patients.

Methods: Thirty 30 BRVO patients and 30 healthy subjects were included in this study. Nitrate-mediated dilatation (NMD) which represent smooth muscle relaxation and flow-mediated dilation (FMD) which represent the endothelium-dependent relaxation of the brachial artery were measured by ultrasonography. Biochemical and laboratory tests including total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein (Apo)-A1, Apo-B and mean systolic blood pressure (SBP), diastolic blood pressure (DBP) were also considered. 

Results: The median NMD value was 15.55 (12.3/25) % in the control group and 12.5 (8.3/18.7) in the BRVO group (p < 0.001). The mean FMD value was 9.71 ± 2.19% in the control group and 5.13 ± 2.72 % in the BRVO group (p = 0.002). The mean SBP value was 117.17 ± 7.01 in the control group and 140.17 ± 10.38 in the BRVO group (p = 0.001). The median DBP value was 75.5 (61/84) in the control group and 89.5 (68/109) in the BRVO group (p < 0.001). Also, FMD and SBP were found as an independent risk factor for BRVO (p = 0.040 and p = 0.019). 

Conclusion: Impaired brachial artery NMD and FMD levels may imply that not only endothelial dysfunction also smooth muscle cell dysfunction may play a role in the occurrence of BRVO. Also, these parameters can be used for further analyses of these patients.

Keywords: Branch Retinal Vein Occlusion; Flow-Mediated Dilation; Nitrate-Mediated Dilatation; Endothelial Dysfunction; Smooth Muscle Cell Dysfunction

References

  1. Bertelsen M., et al. “Comorbidity in patients with branch retinal vein occlusion: case-control study”. British Medical Journal 345 (2012): e7885.
  2. Lee JY., et al. “Baseline characteristics and risk factors of retinal vein occlusion: a study by the Korean RVO Study Group”. Journal of Korean Medical Science 28 (2013): 136-144.
  3. Newman-Casey PA., et al. “Risk factors associated with developing branch retinal vein occlusion among enrollees in a United States managed care plan”. Ophthalmology 121 (2014): 1939-1948.
  4. Zhou JQ., et al. “The 10-year incidence and risk factors of retinal vein occlusion: the Beijing eye study”. Ophthalmology 120 (2013): 803-808.
  5. Budzinskaia MV., et al. “The role of lipid metabolism and antioxidant system changes in the development of retinal vein occlusion”. Vestnik Oftalmologii 130 (2014): 3-8.
  6. Jaulim A., et al. “Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature”. Retina 33 (2013): 901-910.
  7. Lahiri KD., et al. “Hyperhomocysteinemia, as an independent risk factor for retinal venous occlusion in an Indian population”. Indian Journal of Clinical Biochemistry 28 (2013): 61-64.
  8. Glueck CJ., et al. “Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions”. Clinical and Applied Thrombosis/Hemostasis 14 (2008): 286-294.
  9. Seitz R. “The Retinal Vessels: Comparative Ophthalmoscopic and Histologic Studies on Healthy and Diseased Eyes”. St. Louis, MO: CV Mosby (1964): 28.
  10. Frangieh GT., et al. “Histopathologic study of branch retinal vein occlusion”. Archives of Ophthalmology 100 (1982): 1132-1140.
  11. Celermajer DS., et al. “Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis”. Lancet 340 (1992): 1111-1115.
  12. Corretti MC., et al. “Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force”. The Journal of the American College of Cardiology 39 (2002): 257-265.
  13. Järvisalo MJ., et al. “Determinants of arterial nitrate-mediated dilatation in children: role of oxidized low-densitylipoprotein, endothelial function, and carotid intima-media thickness”. Circulation 109 (2004): 2885-2889. 
  14. Deng YB., et al. “Evaluation of endothelial function in hypertensive elderly patients by high-resolution ultrasonography”. Clinical Cardiology 22 (1999): 705-710.
  15. Naka KK., et al. “Determinants of vascular function in patients with type 2 diabetes”. Cardiovascular Diabetology 11 (2012): 127.
  16. Tanano I., et al. “Impaired systemic vascular endothelial function in patients with branch retinal vein occlusion”. Current Eye Research 38 (2013): 114-118.
  17. Adams MR., et al. “Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis”. Journal of the American College of Cardiology 32 (1998): 123-127.
  18. Rossen JD., et al. “Effect of adenosine antagonism on metabolically mediated coronary vasodilation in humans”. Journal of the American College of Cardiology 23 (1994): 1421-1426.
  19. Feletou M and Vanhoutte PM. “The alternative: EDHF”. The Journal of Molecular and Cellular Cardiology 31 (1999): 15-22.
  20. Baursachs J., et al. “The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells”. Pflügers Archiv 442 (2001): 511-518.
  21. Fraenkl SA., et al. “Retinal vein occlusions: the potential impact of a dysregulation of the retinal veins”. EPMA Journal 1 (2010): 253-261.
  22. Lam HD., et al. “Young patients with branch retinal vein occlusion: a review of 60 cases”. Retina 30 (2010): 1520-1523.
  23. Klein R., et al. “The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study”. Transactions of the American Ophthalmological Society 98 (2000): 133-141.
Citation: Sinan Bilgin., et al. “Assessment of Smooth Muscle Cell and Endothelial Functions in Branch Retinal Vein Occlusion”. EC Ophthalmology 11.4 (2020): 31-36.

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