Research Article
Volume 11 Issue 4 - 2020
Assessment of Smooth Muscle Cell and Endothelial Functions in Branch Retinal Vein Occlusion
Sinan Bilgin1*, Ozcan Kayikcioglu2, Tansu Erakgun3 and Meral Kayikcioglu4
1Department of Ophthalmology, Medifema Hospital, Izmir, Turkey
2Department of Ophthalmology, Hafsa Sultan Hospital, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
3Ekol Eye Health Center, Izmir, Turkey
4Department of Cardiology, Ege University, Izmir, Turkey
*Corresponding Author: Sinan Bilgin, Department of Ophthalmology, Medifema Hospital, Izmir, Turkey.
Received: February 18, 2020; Published: March 16, 2020


Purpose: One of the common retinal vascular disorder is branch retinal vein occlusion (BRVO) that causes visual impairment. The purpose of this study is to evaluate vascular smooth muscle cell and endothelial functions in BRVO patients.

Methods: Thirty 30 BRVO patients and 30 healthy subjects were included in this study. Nitrate-mediated dilatation (NMD) which represent smooth muscle relaxation and flow-mediated dilation (FMD) which represent the endothelium-dependent relaxation of the brachial artery were measured by ultrasonography. Biochemical and laboratory tests including total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein (Apo)-A1, Apo-B and mean systolic blood pressure (SBP), diastolic blood pressure (DBP) were also considered. 

Results: The median NMD value was 15.55 (12.3/25) % in the control group and 12.5 (8.3/18.7) in the BRVO group (p < 0.001). The mean FMD value was 9.71 ± 2.19% in the control group and 5.13 ± 2.72 % in the BRVO group (p = 0.002). The mean SBP value was 117.17 ± 7.01 in the control group and 140.17 ± 10.38 in the BRVO group (p = 0.001). The median DBP value was 75.5 (61/84) in the control group and 89.5 (68/109) in the BRVO group (p < 0.001). Also, FMD and SBP were found as an independent risk factor for BRVO (p = 0.040 and p = 0.019). 

Conclusion: Impaired brachial artery NMD and FMD levels may imply that not only endothelial dysfunction also smooth muscle cell dysfunction may play a role in the occurrence of BRVO. Also, these parameters can be used for further analyses of these patients.

Keywords: Branch Retinal Vein Occlusion; Flow-Mediated Dilation; Nitrate-Mediated Dilatation; Endothelial Dysfunction; Smooth Muscle Cell Dysfunction


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Citation: Sinan Bilgin., et al. “Assessment of Smooth Muscle Cell and Endothelial Functions in Branch Retinal Vein Occlusion”. EC Ophthalmology 11.4 (2020): 31-36.

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