Research Article
Volume 11 Issue 4 - 2020
Comparison of Anti VEGF and Laser Photocoagulation in Diabetic Macular Edema (DME)
Salma Mahmoud El Awad1, Nuha Mohamed Fath Elrahman2, Muhammad Ijaz Ahmad3, Abd Elaziz Mohamed Elmadina4*, Manzoor Ahmad Qureshi5, Adil Mousa Younis6, Abrar Ahmad Bhatti7 and Mosab Nouraldein Mohammed Hamad8
1Postgraduate Student in Alneelain University, Khartoum, Sudan
2Assistant Professor, Faculty of Optometry and Visual Science, Alneelain University, Khartoum, Sudan
3Assistant Professor Ophthalmology, Qassim Medical University, Saudi Arabia and Allied Hospital, Department of Ophthalmology, Punjab Medical College, Faisalabad, Pakistan
4Assistant Professor, Faculty of Optometry and Visual Science, Alneelain University, Sudan and Assistant Professor, Optometry Department, College of Applied Medical Sciences, Qassim University, Saudi Arabia
5Assistant Professor of Ophthalmology, Qassim Medical University, Saudi Arabia and Department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro, Hyderabad, Pakistan
6Associate Professor Q.U.S.A. CEB, Saudi Arabia
7Consultant Ophthalmologist King Fahd Specialist Hospital Buraidha, KSA and Services Institute of Medical Sciences Lahore (SIMS), Services Hospital, Pakistan
8Faculty of Health Sciences, Elsheikh Abdallah Elbadri University, Sudan
*Corresponding Author: Abd Elaziz Mohamed Elmadina, Assistant Professor, Faculty of Optometry and Visual Science, Alneelain University, Sudan and Assistant Professor, Optometry Department, College of Applied Medical Sciences, Qassim University, Saudi Arabia.
Received: February 19, 2020; Published: March 12, 2020




Abstract

Background: To investigate the relationship of central macular thickness measure and visual acuity in diabetic macular edema (DME) before and after treatments using Ranibizumab, Bevacizumab and laser.

Materials and Methods: A comparative cross-sectional retrospective study was done in Khartoum state at Al Faisal Eye Center. Heidelberg OCT was used to measure central macular thickness and visual acuity (BCVA) was evaluated by Snellen’s chart. The data were analyzed by SPSS 20.

Result: A total of 102 treated patients including both male/female were enrolled with mean age 55 ± 5.41. Paired sample t-test showed a significant difference in all types of treatments based on mean vision of treated patients. With Ranibizumab the pre and post treatment mean vision was (0.20 ± 0.16) and (0.30 ± 0.25) respectively with t (-3.2) and P value 0.002. With Bevacizumab it was (0.18 ± 0.16) and (0.37 ± 0.26) respectively with t (-6.12) P value < 0.001 and with laser it was (0.28 ± 0.20) and (0.38 ± 0.27) respectively with t (-2.8) and P value 0.008.A significant difference was found in all types of treatments regarding mean of central macular thickness of treated patients. In patients treated with Ranibizumab the pre and post treatment thickness was (403.6 ± 127) and (293.6 ± 72.7) respectively with t (5.92), with Bevacizumab it was (389.3 ± 134.2) and (276.1 ± 62.6) respectively with t (5.93) and with laser it was (370.1 ± 120.7) and (280.9 ± 64.3) respectively with t (4.67) and P value < 0.001.

Conclusion: Diabetic macular edema leads to blurred vision ranging from slight blurring to noticeable vision loss and Bevacizumab showed sustained improvements in vision and retinal anatomy than Ranibizumab and laser.

 Keyword: Central Macular Thickness; Vascular Endothelial Growth Factor; Vision; Diabetic Macular Edema; Ocular Coherence Tomography

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Citation: Abd Elaziz Mohamed Elmadina., et al. “Comparison of Anti VEGF and Laser Photocoagulation in Diabetic Macular Edema (DME)”. EC Ophthalmology 11.4 (2020): 19-24.

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