Mini Review
Volume 11 Issue 2 - 2020
New Methods for Spatial Analysis of Thickness in Optical Coherence Tomography
Luis Jáñez-Escalada*
Instituto de Tecnología del Conocimiento, Universidad Complutense de Madrid, Spain
*Corresponding Author:Luis Jáñez-Escalada, Instituto de Tecnología del Conocimiento, Universidad Complutense de Madrid, Spain.
Received: December 04, 2019; Published: January 23, 2020


The retina is the most accessible alive neuronal tissue and is relevant not only for ophthalmology but also for neuroscience, because of the increasing evidence that it shows degeneration processes similar to those found in the brain of patients with Alzheimer’s disease and Amyotrophic Lateral Sclerosis. Optical Coherence Tomography (OCT) provides retinal scanning noninvasively, in few seconds, at low cost, and with a spatial resolution thousand times finer than what today is feasible in the living brain. But OCT data have some features derived from its 3D structure that render unsuited classical data analysis methods. Current proposal is to systematically incorporate to their analysis new techniques including geometric corrections of each OCT to eliminate noise inherent to the technique, spatial normalization of all OCTs to achieve their anatomical correspondence, and advanced statistical techniques-based on theories of random fields or random permutations- to precisely locate thickness changes in total retina or in its layers. These methodologies are already available and have proven their usefulness when applied to OCT data to reveal the localization, size and shape of lesions caused in ten retinal layers by Alzheimer’s disease.

Keywords: Optical Coherence Tomography (OCT); Alzheimer’s Disease; Amyotrophic Lateral Sclerosis


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Citation: Luis Jáñez-Escalada. “New Methods for Spatial Analysis of Thickness in Optical Coherence Tomography”. EC Ophthalmology 11.2 (2020): 01-05

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