Case Report
Volume 9 Issue 8 - 2018
Analysis of Optic Nerve Head Circulation Using Laser Speckle Flowgraphy in a Case of Pediatric Optic Neuritis
Ryuya Hashimoto*, Mizuho Oyamada and Takatoshi Maeno
Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan
*Corresponding Author: Ryuya Hashimoto, Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan.
Received: June 26, 2018; Published: July 20, 2018
Citation: Ryuya Hashimoto., et al. “Analysis of Optic Nerve Head Circulation Using Laser Speckle Flowgraphy in a Case of Pediatric Optic Neuritis”. EC Ophthalmology 9.8 (2018): 572-581.
Abstract
Background: To examine the long time course of optic nerve head (ONH) blood flow in a case of pediatric anterior optic neuritis (ON) using laser speckle flowgraphy (LSFG) and optical coherence tomography (OCT).
Case presentation: A 7-year-old Japanese girl presented with a complaint of blurred vision in the right eye, which had a visual acuity of 20 cm/hand motion. The findings of Goldmann visual field test and fundus examination revealed central scotoma and optic disc edema in the right eye, respectively. The results of LSFG demonstrated that the mean blur rate (MBR)-which indicates blood flow-of ONH tissues (MT) was greater in the affected eye (18.8) than in the fellow eye (13.4). In contrast, there was no difference in MBR of arterioles between the two eyes. Vascular cloud (VC)-a parameter measured by the LSFG analysis software and which demonstrates the clarity of the network of vessels in the ONH-in the affected eye (0.26) was lower than that in the fellow eye (0.34), because the run of vessels in the former was unclear owing to inflammation. According to OCT findings, the circumpapillary retinal nerve fiver layer thickness (cpRNFLT) of the affected eye (150 μm) was greater than that of the fellow eye (104 μm). The patient was diagnosed with anterior ON and started on steroid treatment. A week after treatment, the decimal BCVA had recovered to 1.5, and the MT tended to decrease (12.8) with decrease in cpRNFLT (111 μm) in the affected eye. The value of VC gradually increased (0.34) with increase in the clarity of network of vessels in the ONH. Four years after treatment, while there was no difference in MT between the affected (11.0) and fellow (11.1) eyes, the cpRNFLT of the affected eye (78 μm) was lower than that of the fellow eye (106 μm).
Conclusions: This report demonstrates the long-term course of ocular circulation and cpRNFLT in a case of pediatric anterior ON before and after treatment for the first time. Both MT and VC might be useful and effective quantitative indicators of therapeutic efficiency in pediatric anterior ON.
Keywords: Optic Neuritis; Pediatric; Blood Flow; Optic Nerve; Laser Speckle Flowgraphy; Ocular Circulation
Copyright: © 2018 Ryuya Hashimoto., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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