Review Article
Volume 17 Issue 3 - 2022
Oleocanthal and Human Health – An Overview
RE Carlson1 and JA von Fraunhofer2*
1Executive Director, Research and Analytical Sciences, D. Gary Young Research Institute, Lehi, UT
2Professor Emeritus, University of Maryland, Baltimore, MD, USA
*Corresponding Author: JA Von Fraunhofer, Professor Emeritus, University of Maryland, Baltimore, MD, USA.
Received: January 22, 2022; Published: February 28, 2022


The chemistry of oleocanthal (OCL) and its presence in, and extraction from, extra virgin olive oil (EVOO) is briefly discussed. The health benefits of OCL are reviewed, notably its nonsteroidal anti-inflammatory drug activity shown by in vitro studies to modulate NO production in chondrocytes. Consequently, OCL is a promising agent for the treatment of inflammation in cartilage and also to prevent disease progression. Studies also indicate that OCL may have a beneficial effect on the progress of Alzheimer’s disease, the neurodegenerative disease characterized by accumulation of β-amyloid and tau proteins in the brain. There are also in vitro studies indicating that OCL has antitumor activity against various tumor models. Clinical studies have shown that ingestion of EVOO with a high OCL content had clear beneficial effects on metabolic parameters, inflammatory cytokines and abdominal fat distribution in the test subjects.

Keywords: Oleocanthal; Human Health


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Citation: RE Carlson and JA von Fraunhofer. “Oleocanthal and Human Health – An Overview”. EC Nutrition 17.3 (2022): 40-44.

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