Abstract

Osteoarthritis is becoming a common disorder among all age groups. Meanwhile bioactive nonfood matrices are realized to display desired therapeutic actions. Nutraceutical blends of Camellia sinensis and Euphorbia prostrata aqueous extract were prepared and evaluated as fast disintegrating granules. Formula optimization was achieved by a 2³ Taguchi Orthogonal Arrays on Design Expert^© Version 8.0 (freeware). Powder mix was then prepared by mixers then granules’ particle size, friability and densities for flowability evaluated. Anti-arthritic activity was tested biochemically by Bovine Serum denaturation and Egg Albumin Denaturation methods. Ethanol Soxhlet extractions yielded 22.8% and 17.8% percentage yields for C. sinensis and E. prostrata, respectively. The optimized blend ratio was 3:1 for C. sinensis : E. prostrata at a concentration of 2.5 µg.mL^-1. This gave protein denaturation of only 6.0% implying a 94% protection compared to the control at 89.95%. An inhibition of 65% was recorded in egg albumin protein method. Angle of repose of 27^o implied good flowability. Additionally, bulk and tapped densities were significantly low, indicating suitable powder particle packing. The C. sinensis - E. prostrata nutraceutical powder stands as a novel herbal-based solid dosage formulation with optimum rheological characteristics for rapid disintegration and osteoarthritis management adequacies.

Keywords: Nutraceuticals; Osteoarthritis; Powder; Flowability; Biochemical

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