Editorial
Volume 16 Issue 6 - 2021
Vitamin-D and it’s Health Effects Over Humans
Paul Clayton*
Clinical Pharmacologist and Pharmaco-Nutritionist, United Kingdom
*Corresponding Author: Paul Clayton, Clinical Pharmacologist and Pharmaco-Nutritionist, United Kingdom.
Received: March 26, 2021; Published: May 27, 2021




Vitamin’ D and melatonin are pluripotent compounds. Some think of them as vitamins, but they are more convincingly classified as hormones. These two molecules interact with each other in an incredibly complex circadian dance [1], a dance that affects us profoundly. Due to modern lifestyles, more and more of us are out of step, and suffering ill health as a result.

‘Vitamin’ D is the hormone of sunlight, and melatonin is its dark twin. Both molecules appear very early in the evolutionary tree, and both play key roles in defending the cell’s ability to generate biologically useful energy in the mitochondria, around the clock. This goes some way to explaining the importance of D and melatonin to our health, and their involvement in many diseases.

References

  1. Mocayar Marón FJ., et al. “Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin”. The Journal of Steroid Biochemistry and Molecular Biology 199 (2020): 105595.
  2. Wiseman H. “Vitamin D is a membrane antioxidant. Ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action”. FEBS Letters 1-3 (1993): 285-288.
  3. Ansari MGA., et al. “Vitamin D Supplementation is Associated with Increased Glutathione Peroxidase-1 Levels in Arab Adults with Prediabetes”. Antioxidants2 (2020): 118.
  4. Forster RE., et al. “Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells”. Biochemical and Biophysical Research Communications 414 (2011): 557-562.
  5. Chen Z., et al. “Klotho deficiency aggravates diabetes-induced podocyte injury due to DNA damage caused by mitochondrial dysfunction”. International Journal of Medical Sciences 17 (2020): 2763-2772.
  6. Chandel N., et al. “Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes”. Experimental and Molecular Pathology 102 (2017): 97-105.
  7. Manna P., et al. “Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice”. Archives of Biochemistry and Biophysics 615 (2017): 22-34.
  8. Kim YO., et al. “Preconditioning with 1,25-dihydroxyvitamin D3 protects against subsequent ischemia- reperfusion injury in the rat kidney”. Nephron Experimental Nephrology 2 (2005): e85-94.
  9. Leu JI., et al. “Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function”. Oncotarget28 (2017): 45656-45669.
  10. Silvagno F., et al. “Mitochondrial localization of vitamin d receptor in human platelets and differentiated megakaryocytes”. PLoS One 5 (2010): e8670.
  11. Silvagno F., et al. “Mitochondrial translocation of vitamin d receptor is mediated by the permeability transition pore in human keratinocyte cell line”. PLoS One 8 (2013): e54716.
  12. Tanwar J., et al. “Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics”. Mitochondrion 57 (2020): 9-22.
  13. Wang H., et al. “Mitochondria regulation in ferroptosis”. European Journal of Cell Biology 1 (2020): 151058.
  14. Tadokoro T., et al. “Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity”. JCI Insight9 (2020): e132747.
  15. Sun L., et al. “Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms”. DNA and Cell Biology (2020).
  16. Sahu A., et al. “Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration”. Nature Communications 1 (2018): 4859.
  17. Lee SH., et al. “Sirtuin signaling in cellular senescence and aging”. BMB Reports 1 (2019): 24-34.
  18. Sahu A., et al. “Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration”. Nature Communications 1 (2018): 4859.
  19. Bozaykut P., et al. “The role of heat stress on the age related protein carbonylation”. Journal of Proteomics 89 (2013): 238-254.
  20. Haas RH. “Mitochondrial Dysfunction in Aging and Diseases of Aging”. Biology2 (2019): 48.
  21. Blajszczak CC Nonn. “Vitamin D regulates prostate cell metabolism via genomic and non-genomic mitochondrial redox-dependent mechanisms”. The Journal of Steroid Biochemistry and Molecular Biology 195 (2019): 105484.
  22. Dzik KP., et al. “Vitamin d deficiency is associated with muscle atrophy and reduced mitochondrial function in patients with chronic low back pain”. Oxidative Medicine and Cellular Longevity (2019): 6835341.
  23. Montenegro KR., et al. “Effects of vitamin D on primary human skeletal muscle cell proliferation, differentiation, protein synthesis and bioenergetics”. The Journal of Steroid Biochemistry and Molecular Biology 193 (2019): 105423.
  24. Ryan ZC., et al. “1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells”. Journal of Biological Chemistry 3 (2016): 1514-1528.
  25. Sinha A., et al. “Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle”. The Journal of Clinical Endocrinology and Metabolism 98 (2013): E509-513.
  26. Reiter RJ., et al. “Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas”. Cellular and Molecular Life Sciences 74 (2017): 3863-3881.
  27. Venegas C., et al. “Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations”. Journal of Pineal Research 52 (2012): 217-227.
  28. Tan DX., et al. “The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness”. Biological reviews of the Cambridge Philosophical Society 3 (2010): 607-623.
  29. Wang L., et al. “Plant mitochondria synthesize melatonin and enhance the tolerance of plants to drought stress”. Journal of Pineal Research 3 (2017).
  30. Zheng X., et al. “Chloroplastic biosynthesis of melatonin and its involvement in protection of plants from salt stress”. Scientific Reports 7 (2017): 41236.
  31. Manchester LC., et al. “Melatonin: an ancient molecule that makes oxygen metabolically tolerable”. Journal of Pineal Research 4 (2015): 403-419.
  32. Mahmood D. “Pleiotropic effects of melatonin”. Drug Research 69 (2019): 65-74.
  33. Slominski AT., et al. “Melatonin, mitochondria, and the skin”. Cellular and Molecular Life Sciences 74 (2017): 3913-3925.
  34. Ko JW., et al. “Melatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, Klotho”. Food and Chemical Toxicology 129 (2019): 201-210.
  35. Sahan A., et al. “Melatonin prevents deterioration of erectile function in streptozotocin-induced diabetic rats via sirtuin-1 expression”. Andrologia9 (2020): e13639.
  36. Belenichev IF., et al. “Study of the expression pattern of mRNA Hsp70 and the level of HSP70 protein in experimental subtotal ischemia and in the contrast of pharmacological correction of HSP70 modulators”. Biol Mark Guid Ther1 (2018): 75-84.
  37. Menendez JA., et al. “Gerosuppressant metformin: less is more”. Aging4 (2011): 348-362.
  38. Sarlak G., et al. “Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration”. Journal of Pharmacological Sciences 123 (2013): 9-24.
  39. Dezfouli MA., et al. “Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrialbiogenesis; involvement of hippocampal Sirtuin-1 signaling pathway”. Physiology and Behavior 204 (2019): 65-75.
  40. Savran M., et al. “Melatonin protects the heart and endothelium against high fructose corn syrup consumption-induced cardiovascular toxicity via SIRT-1 signaling”. Human and Experimental Toxicology 10 (2019): 1212-1223.
  41. Ding M., et al. “Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway”. Journal of Pineal Research 65 (2018): e12491.
  42. Li J., et al. “Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function”. Molecular Medicine Reports 2 (2019): 1318-1330.
  43. Proietti S., et al. “Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells”. Journal of Pineal Research 2 (2011): 150-158.
  44. Huang C-H., et al. “Prevalence and predictors of hypovitaminosis D among the elderly in subtropical region”. PLoS ONE7 (2017): e0181063.
  45. Brismar K., et al. “Melatonin secretion related to side-effects of beta-blockers from the central nervous system”. Acta Medica Scandinavica 6 (1988): 525-530.
  46. Murphy PJ., et al. “Nonsteroidal anti-inflammatory drugs alter body temperature and suppress melatonin in humans”. Physiology and Behavior 1 (1996): 133-139.
  47. Kurhaluk N and Tkachenko H. “Melatonin and alcohol-related disorders”. Chronobiology International 6 (2020): 781-803.
  48. Molcan L., et al. “Dim light at night attenuates circadian rhythms in the cardiovascular system and suppresses melatonin in rats”. Life Sciences 231 (2019): 116568.
  49. De Goede P., et al. “Circadian rhythms in mitochondrial respiration”. Journal of Molecular Endocrinology 3 (2018): R115-R130.
  50. Ma P., et al. “Evolution of KaiC-Dependent Timekeepers: A Proto-circadian Timing Mechanism Confers Adaptive Fitness in the Purple Bacterium Rhodopseudomonas palustris”. PLOS Genetics 3 (2016): e1005922.
Citation: Paul Clayton. “Vitamin-D and it’s Health Effects Over Humans”. EC Nutrition 16.6 (2021): 01-05.

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