Short Communication
Volume 15 Issue 11 - 2020
Headline: Is Parkinsonism Contagious?
Paul Clayton*
Clinical Pharmacologist and Pharmaco-Nutritionist, United Kingdom
*Corresponding Author: Paul Clayton, Clinical Pharmacologist and Pharmaco-Nutritionist, United Kingdom.
Received: October 01, 2020; Published: October 30, 2020

Keywords: Parkinsonism; Bacteria; Viruses; Dysbiosis; Inflammation; Prebiotic; Alpha Synuclein

In an earlier post I cherry-picked some of the data linking dysbiosis to Parkinsonian Syndrome (PS). Dysbiosis is not the whole answer. As with Alzheimer’s, a patient may arrive at a clinically identical end-state via different routes; as indicated by the range of risk factors which include various genes, environmental toxins including carbamate and organochlorine pesticides, certain drugs and the closely related trio of dietary elements, microbiota and bacterial metabolites. Fewer than 10% of cases are hereditary [1] and it is the diet/microbiota link that currently seems to be the most important. This would explain why the incidence of Parkinsonism has increased exponentially since the 19th century [2,3] and increases rapidly in non-Western societies as they move towards a Western/industrial diet [4]. This, of course, raises the exciting possibility of risk reduction via dietary intervention, which is what I want to explore here.


  1. Nalls MA. “Multiple authors. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease”. Nature Genetics 9 (2014): 989-993.
  2. Louis ED. “The Shaking Palsy, the First Forty-Five Years: A Journey Through the British Literature”. Movement Disorders 6 (1997): 1068-1072.
  3. Savica R., et al. “Time Trends in the Incidence of Parkinson Disease”. JAMA Neurology 8 (2016): 981-999.
  4. GBD 2016 Parkinson's Disease Collaborators. Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016”. The Lancet Neurology 11 (2018): 939-953.
  5. Labrie V and Brundin P. “Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection”. The Journal of Innate Immunity 5 (2017): 437-440.
  6. Stolzenberg E., et al. “A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity”. The Journal of Innate Immunity 5 (2017): 456-463.
  7. Plouvier AO., et al. “Prodromal symptoms and early detection of Parkinson’s disease in general practice: a nested case-control study”. Family Practice 31 (2014): 373-378.
  8. Lin CH., et al. “Risk of Parkinson’s disease following severe constipation: a nationwide population-based cohort study”. Parkinsonism and Related Disorders 20 (2014): 1371-1375.
  9. Peter I., et al. “Anti-Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease”. JAMA Neurology 8 (2018): 939-946.
  10. Villumsen M., et al. “Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014”. Gut1 (2019): 18-24.
  11. Svensson E., et al. “Vagotomy and subsequent risk of Parkinson's disease”. Annals of Neurology 4 (2015): 522-529.
  12. Holmqvist S., et al. “Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats”. Acta Neuropathologica 6 (2014): 805-820.
  13. Braak H., et al. “Staging of brain pathology related to sporadic Parkinson’s disease”. Neurobiology of Aging 24 (2003): 197-211.
  14. Sampson TR., et al. “Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease”. Cell6 (2016): 1469-1480.e12.
  15. Ishibashi T. “Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases”. Current Pharmaceutical Design 19 (2013): 6375-6381.
  16. Suzuki A., et al. “Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease”. PLoS One 12 (2018): e0208313.
  17. Tuovinen E., et al. “Cytokine response of human mononuclear cells induced by intestinal Clostridium species”. Anaerobe 19 (2013): 70-76.
  18. Egshatyan L., et al. “Gut microbiota and diet in patients with different glucose tolerance”. Endocrine Connections 1 (2016): 1-9.
  19. Guo P., et al. “Clostridium species as probiotics: potentials and challenges”. Journal of Animal Science and Biotechnology 11 (2020): 24.
  20. Lange K., et al. “Comparison of the effects of five dietary fibers on mucosal transcriptional profiles, and luminal microbiota composition and SCFA concentrations in murine colon”. Molecular Nutrition and Food Research 59 (2015): 1590-1602.
  21. Kelly LP., et al. “Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease”. Movement Disorders 8 (2014): 999-1009.
  22. Clayton P and Rowbotham J. “An unsuitable and degraded diet? Part two: realities of the mid-Victorian diet”. Journal of the Royal Society of Medicine 7 (2008): 350-357.
  23. Reynolds A., et al. “Carbohydrate quality and human health: a series of systematic reviews and meta-analyses”. Lancet10170 (2019): 434-445.
  24. Moshfegh AJ., et al. “Presence of Inulin and Oligofructose in the Diets of Americans”. Journal of Nutrition 7 (1999): 1407S-1411S.
  25. Haskey N and GibsonDL. “An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease”. Nutrients 3 (2017): 259.
  26. Boulos C., et al. “Nutritional Risk Factors, Microbiota and Parkinson's Disease: What Is the Current Evidence?” Nutrients8 (2019): 1896.
  27. Sampson TR., et al. “A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice”. Elife 9 (2020): e53111.
  28. Tursi SA and Tükel Ç. “Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications”. Microbiology and Molecular Biology Reviews 4 (2018): e00028-e00018.
  29. Chen CC., et al. “Antimicrobial Activity of Lactobacillus Species Against Carbapenem-Resistant Enterobacteriaceae”. Frontiers in Microbiology 10 (2019): 789.
  30. Ho L., et al. “Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity”. Journal of Nutritional Biochemistry 64 (2019): 170-181.
  31. Ozdal T., et al. “The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility”. Nutrients 2 (2016): 78.
  32. Ricci JER., et al. “Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn's Disease Patients”. Journal of Clinical Gastroenterology 6 (2018): 530-536.
  33. Fasano A., et al. “The role of small intestinal bacterial overgrowth in Parkinson's disease”. The Journal of Movement Disorders 9 (2013): 1241-1249.
  34. Tan AH., et al. “Small intestinal bacterial overgrowth in Parkinson's disease”. Parkinsonism and Related Disorders 5 (2014): 535-540.
  35. Nielsen HH., et al. “Treatment for Helicobacter pylori infection and risk of Parkinson's disease in Denmark”. European Journal of Neurology 6 (2012): 864-869.
  36. Bjarnason IT., et al. “Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 2: response of facets of clinical idiopathic parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, placebo-controlled efficacy study”. Helicobacter 4 (2005): 276-287.
  37. Goya ME., et al. “Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans”. Cell Reports 2 (2020): 367-380.
  38. Cogliati S., et al. “Bacillus Subtilis Delays Neurodegeneration and Behavioral Impairment in the Alzheimer’s Disease Model Caenorhabditis Elegans”. Journal of Alzheimer's Disease (2019).
  39. Fullard ME., et al. “Olfactory Dysfunction as an Early Biomarker in Parkinson's Disease”. Neuroscience Bulletin 5 (2017): 515-525.
  40. Hanaoka A and Kashihara K. “Increased frequencies of caries, periodontal disease and tooth loss in patients with Parkinson's disease”. Journal of Clinical Neuroscience 10 (2009): 1279-1282.
  41. Einarsdóttir ER., et al. “Dental health of patients with Parkinson's disease in Iceland”. Special Care in Dentistry 3 (2009): 123-127.
  42. Kaur T., et al. “Parkinson's disease and periodontitis - the missing link? A review”. Gerodontology4 (2016): 434-438.
  43. Chen CK., et al. “Dental Scaling Decreases the Risk of Parkinson's Disease: A Nationwide Population-Based Nested Case-Control Study”. International Journal of Environmental Research and Public Health 8 (2018): 1587.
  44. Chen SG., et al. “Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans”. Scientific Reports 6 (2016): 34477.
  45. Allen L. “Are we facing a noncommunicable disease pandemic?” Journal of Epidemiology and Global Health 1 (2017): 5-9.
  46. Sonnenburg ED and Sonnenburg JL. “The ancestral and industrialized gut microbiota and implications for human health”. Nature Reviews Microbiology 6 (2019): 383-390.
  47. Krashia P., et al. “Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease”. Nature Communications 1 (2019): 3945.
  48. Xu J., et al. “Resolvin D1 Attenuates Mpp+-Induced Parkinson Disease via Inhibiting Inflammation in PC12 Cells”. Medical Science Monitor 23 (2017): 2684-2691.
  49. Tian Y., et al. “Resolvin D2 recovers neural injury by suppressing inflammatory mediators expression in lipopolysaccharide-induced Parkinson’s disease rat model”. Biochemical and Biophysical Research Communications 3 (2015): 799-805.
  50. Narayan S., et al. “Occupational pesticide use and Parkinson's disease in the Parkinson Environment Gene (PEG) study”. Environment International 107 (2017): 266-273.
  51. Liang Y., et al. “Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota”. Microbiome1 (2019): 19.
  52. Prange S., et al. “Age and time course of long-term motor and nonmotor complications in Parkinson disease”. Neurology2 (2019): e148-e160.
  53. Requena T., et al. “Diet and Microbiota Linked in Health and Disease”. Food and Function 2 (2018): 688-704.
  54. Barratt MJ., et al. “The Gut Microbiota, Food Science, and Human Nutrition: A Timely Marriage”. Cell Host Microbe2 (2017): 134-141.
Citation: Paul Clayton. “Headline: Is Parkinsonism Contagious?”. EC Nutrition 15.11 (2020): 39-44.

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