Review Article
Volume 15 Issue 6 - 2020
Biomedical Importance of Thiamin and Impact on Mitochondrial Machinery
Ramadhan Oruch1* and Ian F Pryme2
1Department of Biochemistry and Molecular Biology, School of Medicine, Najran University, Najran, Kingdom of Saudi Arabia
2Department of Biomedicine, School of Medicine, University of Bergen, Bergen, Norway
*Corresponding Author: Ramadhan Oruch, Department of Biochemistry and Molecular Biology, School of Medicine, Najran University, Najran, Kingdom of Saudi Arabia.
Received: April 10, 2020; Published: May 13, 2020


Essential micronutrients are primary metabolites that the human body needs for reproduction, growth and survival. These include minerals and vitamins, but not essential fatty acids nor essential amino acids. They are called essential because they cannot be synthesized de novo in the human body neither partially nor completely. These nutrients have huge biological significance in that they are often found together with certain enzymes in complexes that are directly involved in vital metabolic pathways. Among these pathways are glycolysis, Krebs’ cycle, oxidative phosphorylation and the pentose phosphate pathway. Thiamin (also called Thiamine, aneurine or vitamin B1) is one of these essential water-soluble micronutrients that functions as a coenzyme, or prosthetic group, to activate many apoenzymes that are involved in core metabolic processes, without which humans cannot survive. It thus functions as a helper molecule that aids an enzyme in catalyzing a chemical reaction. Deficiency of thiamin can cause many diseases and predispose us to many others indirectly by affecting the function of metabolic pathways, which in-turn disturbs mitochondrial function. Individuals with alcoholism in Western society and pregnant women of the developing world are most prone to this deficiency type of malnutrition. Geriatric and antenatal health care providers must be made aware of the incidence of such a deficiency state. In addition, audiences targeted for this mini review are the following: undergraduates of medicine, pharmacy and nursing, junior doctors of emergency and outpatient units, and doctors and nurses in geriatric units and obstetric hospitals.

Keywords: Micronutrient; Metabolism; Holoenzyme; Cofactor; Krebs Cycle; Antioxidants


  1. Combs Jr GF. “The Vitamins: Fundamental Aspects in Nutrition and Health (3rd edition)”. Ithaca, NY: Elsevier Academic Press (2008).
  2. Mahan LK and Escott-Stump S. “Krause's food, nutrition and diet therapy (10th edition)”. Philadelphia: W.B. Saunders Company (2000).
  3. Institute of Medicine. “Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic acid, Biotin, and Choline”. Washington DC: The National Academies Press (1998): 58-86.
  4. Landsdale D. “A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives”. Evidence-Based Complementary and Alternative Medicine1 (2006): 49-59.
  5. Tanphaichitr V. "Thiamin" In Shils ME, Olsen JA, Shike M., et al. (editions.). Modern Nutrition in Health and Disease (9th ). Baltimore: Lippincott Williams and Wilkins (1999).
  6. Walker J and A Kepner. “Wernicke's encephalopathy presenting as acute psychosis after gastric bypass”. The Journal of Emergency Medicine 5 (2012): 811-814.
  7. Chandrakumar A., et al. “Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis”. The Journal of Basic and Clinical Physiology and Pharmacology 2 (2018): 153-162.
  8. Murphy JV and L Craig. “Leigh's disease: significance of the biochemical changes in brain”. Journal of Neurology, Neurosurgery, and Psychiatry 11 (1975): 1100-1103.
  9. Mishra VV and RA Verneker. “Hyperemesis gravidarum causing Wernicke-Korsakoff syndrome: A rare complication”. Journal of Obstetrics and Gynaecology Research 9 (2019): 1929-1931.
  10. Oudman E., et al. “Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review”. European Journal of Obstetrics and Gynecology and Reproductive Biology 236 (2019): 84-93.
  11. Butterworth RF. “Maternal thiamine deficiency: still a problem in some world communities”. The American Journal of Clinical Nutrition6 (2001): 712-713.
  12. Sasaki T., et al. “[A case of thiamine deficiency with psychotic symptoms--blood concentration of thiamine and response to therapy]”. Seishin Shinkeigaku Zasshi2 (2010): 97-110.
  13. American Society of Health-System Pharmacists. "Thiamine Hydrochloride" (2018).
  14. European Food Safety Authority. "Upper Tolerable Intake Levels for Vitamins and Minerals" (2006).
  15. Mkrtchyan G., et al. “Molecular Mechanisms of the Non-Coenzyme action of Thiamin in Brain: Biochemical, Structural and Pathway Analysis”. Scientific Reports 5 (2015): 12583.
  16. Spaans SK., et al. “NADPH-generating systems in bacteria and archaea”. Frontiers in Microbiology 6 (2015): 742.
  17. Luong KV and LT Nguyen. “The impact of thiamine treatment in the diabetes mellitus”. Journal of Clinical Medicine Research 3 (2012): 153-160.
  18. Schlame M., et al. “Intramembraneous hydrogenation of mitochondrial lipids reduces the substrate availability, but not the enzyme activity of endogenous phospholipase A. The role of polyunsaturated phospholipid species”. Biochimica et Biophysica Acta 1 (1990): 1-8.
  19. Schlame M., et al. “Relationship between lipid saturation and lipid-protein interaction in liver mitochondria modified by catalytic hydrogenation with reference to cardiolipin molecular species”. Biochemical Journal1 (1990): 79-85.
  20. Berg JM., et al. “Oxidative Phosphorylation". Chapter 18, in "Biochemistry" 5th edition (2002): 491-493.
  21. Kloss O., et al. “Thiamin deficiency on fetal brain development with and without prenatal alcohol exposure”. Biochemistry and Cell Biology 2 (2018): 169-177.
  22. Brown G. “Defects of thiamine transport and metabolism”. Journal of Inherited Metabolic Disease 4 (2014): 577-585.
  23. Scriver CR., et al. “Thiamine-responsive maple-syrup-urine disease”. Lancet 7694 (1971): 310-2.
  24. American Society of Health-System Pharmacists. "Thiamine Hydrochloride" (2018).
  25. Alberts B., et al. “Molecular Biology of the Cell”. New York: Garland Publishing Inc (1994).
  26. Voet D., et al. “Fundamentals of Biochemistry”. (2nd) John Wiley and Sons, Inc (2006): 547-556.
  27. Taylor SW., et al. “Characterization of the human heart mitochondrial proteome”. Nature Biotechnology 3 (2003): 281-286.
  28. Gibson GE., et al. “Vitamin B1 (thiamine) and dementia”. Annals of the New York Academy of Sciences 1 (2016): 21-30.
  29. Babenko VN., et al. “Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder”. BMC Neuroscience 1 (2018): 79.
  30. Callaly E., et al. “Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy”. Mini-Reviews in Medicinal Chemistry 5 (2015): 355-365.
  31. Goncalves VF., et al. “Mitochondrial dysfunction in schizophrenia: an evolutionary perspective”. Human Genetics 1 (2015): 13-21.
  32. Hjelm BE., et al. “Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia”. Molecular Neuropsychiatry 4 (2015): 201-219.
  33. Hollis F., et al. “Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives”. Current Opinion in Neurobiology 45 (2017): 178-187.
  34. Holper L., et al. “Brain cytochrome-c-oxidase as a marker of mitochondrial function: A pilot study in major depression using NIRS”. Depress Anxiety8 (2019): 766-779.
  35. Karabatsiakis A., et al. “Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression”. Translational Psychiatry 4 (2014): e397.
  36. Kato T. “Neurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond”. Schizophrenia Research 187 (2017): 62-66.
  37. Kim HK., et al. “Neuropathological relationship between major depression and dementia: A hypothetical model and review”. Progress in Neuro-Psychopharmacology and Biological Psychiatry 67 (2016): 51-57.
  38. Rajasekaran A., et al. “Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications”. Neuroscience and Biobehavioral Reviews 48 (2015): 10-21.
  39. Rose S., et al. “Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder”. Molecular Diagnosis and Therapy 5 (2018): 571-593.
  40. Scaini G., et al. “Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications”. Neuroscience and Biobehavioral Reviews 68 (2016): 694-713.
  41. Alcazar-Leyva S and N Alvarado-Vasquez. “Could thiamine pyrophosphate be a regulator of the nitric oxide synthesis in the endothelial cell of diabetic patients?” Medical Hypotheses 5 (2011): 629-631.
  42. Altinyazar V., et al. “Anorexia nervosa and Wernicke Korsakoff's syndrome: atypical presentation by acute psychosis”. International Journal of Eating Disorders 8 (2010): 766-769.
  43. Felix O., et al. “[Life-threatening complication of schizophrenia]”. Praxis2 (2012): 127-131.
  44. Mantero V., et al. “Non-alcoholic beriberi, Wernicke encephalopathy and long-term eating disorder: case report and a mini-review”. Eating and Weight Disorders (2020).
  45. Lingjaerde PS. “Carbohydrate metabolism in schizophrenia”. International Review of Neurobiology 11 (1968): 259-290.
  46. Lofvendahl H and T Valatin. “Carbohydrate metabolism in schizophrenia”. Acta Medica Scandinavica 106 (1941): 70-80.
  47. Combs GF. “Chapter 10 in The Vitamins” (2012): 216-276.
  48. Martel JL and DS Franklin. “Vitamin B1 (Thiamine)”. In StatPearls: Treasure Island (FL) (2020).
  49. Spittle B and J Parker. “Wernicke's encephalopathy complicating schizophrenia”. Australian and New Zealand Journal of Psychiatry 4 (1993): 638-652.
Citation: Ramadhan Oruch and Ian F Pryme. “Biomedical Importance of Thiamin and Impact on Mitochondrial Machinery”. EC Nutrition 15.6 (2020): 41-51.

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