Research Article
Volume 2 Issue 1 - 2020
Pharmacological Adherence and Knowledge of Anticoagulated Patients
Simone Maria Muniz da Silva Bezerra* and Fabiana Coriolano Ribeiro Cavalcanti
University of Pernambuco, Recife (PE), Brazil
*Corresponding Author: Simone Maria Muniz da Silva Bezerra, University of Pernambuco, Recife (PE), Brazil.
Received: November 05, 2019; Published: December 31, 2019




Abstract

Objective: To investigate the pharmacological adherence and the knowledge of patients undergoing oral anticoagulation therapy with outpatients. 

Method: Cross-sectional study with quantitative approach. 

Results: 222 patients were evaluated, of which 60.8% were classified as non-adherent and 63.1% had inadequate knowledge regarding oral anticoagulant. Non-adherence was related to the longer treatment time (p < 0.001) and to patients with INR values outside the therapeutic range (p = 0.022). Inadequate knowledge was associated with low educational level (p < 0.001), sedentary lifestyle (p = 0.027), shorter outpatient follow-up (p < 0.001), and patients with RNI values outside the therapeutic range (p = 0.012). 

Conclusion: In view of the results, it is evident the need for health education strategies that address this public, considering individual understanding and pharmacological adherence as crucial in therapy.

Keywords: Knowledge; Medication Adherence; Anticoagulant; Nursing

References

  1. Tavares NUL., et al. “Use of medicines for the treatment of chronic non-communicable diseases in Brazil: results of the national health research”. Epidemiologia e Serviços de Saúde 24.2 (2015): 315-323.
  2. Avila CW., et al. “Pharmacological Adherence to Oral Anticoagulant and Factors that Influence the International Normalized Ratio Stability”. Revista Latino-Americana de Enfermagem 19.1 (2011): 18-25.
  3. Corbi ISA., et al. “Health related quality of life of patients undergoing oral anticoagulation therapy”. Revista Latino-Americana de Enfermagem 19.4 (2011): 865-873. 
  4. Carvalho ARS., et al. “Oral Anticoagulation: the impact of the therapy in health-related quality of life at six-month follow-up”. Revista Latino-Americana de Enfermagem 21 (2013): 105-112. 
  5. Remondi FA., et al. “Non-adherence to drug therapy: from theory to clinical practice”. Revista de Ciências Farmacêuticas Básica e Aplicada 35.2 (2014): 177-185. 
  6. Ribeiro and MJCMO. “Evaluation of adherence to rivaroxaban versus enoxaparin therapy [dissertation on the internet]”. University of Beira Interior; Covilhã (2013). 
  7. Aslam F., et al. “Medication non-adherence: the other drug problem”. Hot Topics Cardiology 8 (2012): 7-10. 
  8. Gusmão JL., et al. “Adesão ao tratamento: Conceitos”. Revista Brasileira de Hipertensao 13.1 (2006): 23-25. 
  9. Faria NV., et al. “Users knowledge about the HIPERDIA program and chronic kidney disease”. Journal of Internal Medicine and Primary Health Care 5.1 (2014): 4-9. 
  10. Morisky DE., et al. “Concurrent and predictive validity of self-reported measure of medication adherence”. Med Care 24.1 (1986): 67-74. 
  11. Ben AJ., et al. “The Brief Medication Questionnaire and Morisky Green Test to evaluate medication adherence”. Revista de Saúde Pública 46.2 (2012): 279-289.
  12. Dewulf NLS., et al. “Adherence to drug treatment in patients with chronic gastrointestinal diseases followed at the outpatient clinic of a university hospital”. Revista Brasileira de Ciências Farmacêuticas 42.4 (2006): 575-584. 
  13. Sewitch MJ., et al. “Patient nonadherence to medication in inflammatory Bowel disease”. American Journal of Gastroenterology 98.7 (2003): 1535-1544. 
  14. Rocha HT., et al. “Knowledge of Patients with Mechanical Valve Prostheses Concerning Chronic Oral Anticoagulant Therapy”. Revista Latino-Americana de Enfermagem 18.4 (2010): 696-702.
  15. Henn CB., et al. “Knowledge of patients about chronic oral anticoagulation followed in a specialized outpatient clinic”. Revista Gaúcha de Enfermagem 29.2 (2008): 207-213. 
  16. Brown, TM., et al. “Development of a conceptual model of adherence to oral anticoagulants to reduce risk of stroke in patients with atrial fibrillation”. Journal of Managed Care and Specialty Pharmacy 18.5 (2012): 351-362. 
  17. Ewen S., et al. “Drug adherence in patients taking oral anticoagulation therapy”. Clinical Research in Cardiology 103.3 (2014): 173-182. 
  18. Moran SM., et al. “Warfarin anticoagulation: a survey of patients’ knowledge of their treatment”. Irish Journal of Medical Science 180.4 (2011): 819-822. 
  19. Van Damme S., et al. “Patient knowledge of and adherence to oral anticoagulation therapy after mechanical heart-valve replacement for congenital or acquired valve defects”. Heart Lung 40.2 (2011): 139-146. 
  20. Kitahara ST., et al. “Avaliação da Variação de Razão Normalizada Internacional em Pacientes Anticoagulados através de Metodologia Diferenciada”. Revista Brasileira de Cardiologia 27.5 (2014): 342-348.
  21. Jorgensen AL., et al. “Adherence and variability in warfarin dose requirements: assessment in a prospective cohort”. Pharmacogenomics 14.2 (2013): 151-163. 
  22. Sá LO and Vasconcelos MMVB. “The importance of oral health education in elementary schools: literature review”. Odontologia Clínico-Científica 8.4 (2009): 299-303. 
  23. Chenot J., et al. “Safety relevant knowledge of orally anticoagulated patients without self-monitoring: a baseline survey in primary care”. BMC Family Practice 15 (2014): 104. 
  24. Moreira RP., et al. “Nursing diagnosis of sedentary lifestyle: expert validation”. Texto e Contexto- Enferm 23.3 (2014): 547-554. 
  25. Winans AR., et al. “Assessing anticoagulation knowledge in patients new to warfarin therapy”. Annals of Pharmacotherapy 44.7-8 (2010): 1152-1157.
  26. Girotto E., et al. “Adherence to pharmacological and non-pharmacological treatment and associated factors in primary care of hypertension”. Ciênc Saúde Coletiva 18.6 (2013): 1763-1772. 
  27. Ferguson C., et al. “Atrial fibrillation and thromboprophylaxis in heart failure: the need for patient-centered approaches to address adherence”. Vascular Health and Risk Management 9 (2013): 3-11. 
Citation: Simone Maria Muniz da Silva Bezerra and Fabiana Coriolano Ribeiro Cavalcanti. “Pharmacological Adherence and Knowledge of Anticoagulated Patients”. EC Nursing & Healthcare 2.1 (2020): 01-10.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


March Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the March issue of respective journals and can be viewed in the current issue pages.

Submission Deadline for April Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the May issue of respective journals. Submissions are accepted on/before April 20, 2020.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk