Research Article
Volume 12 Issue 1 - 2020
Using Valproic Acid in Patients with Brain Tumor During Adjuvant Radiotherapy
Aleksandr S Shershever1,2*, Dmitry L Benzion1, Svetlana A Lavrova1, Yuliya A Mironova1 and Gleb V Cherkasov1
1Sverdlovsk Regional Oncological Dispensary, Sverdlovsk Region, Russia
2Urals State Medical University, Yekaterinburg, Sverdlovsk Region, Russia
*Corresponding Author: Aleksandr S Shershever, Professor at the Department of Nervous Diseases, Neurosurgery and Medical Genetics, Ural State Medical University, Yekaterinburg, Sverdlovsk Region, Russia.
Received: November 11, 2019; Published: December 04, 2019


Objective: Epileptic seizures (ES) are quite common in patients with brain tumors. The frequency of ES depends on the location of the tumor, size, histology and type of treatment. We evaluated the efficacy of intravenous valproic acid in patients with seizures associated with a brain tumor (BT) in the postoperative period during adjuvant course of radiotherapy/chemoradiotherapy (RT/ CRT).

Materials and Methods: The prospective study included 879 patients aged 18-78 with brain tumors who received adjuvant course of RT/CRT after brain surgery in 2014-2018. All patients for the duration of the course of RT/CRT were monitored in the radiotherapy department. According to the standard of examination and treatment, all patients were evaluated for clinical and neurological status, electroencephalogram (EEG), brain MRI with intravenous contrast. During the RT procedure the patient should be stay in nonmoving position for 10-30 min. To prevent the development ES (focal and generalized) in patient during RT it was used Valproic acid administered via the intravenous route. The efficacy and safety of Valproic acid was evaluated.

Results: ES was detected in 147 patients (16.7%) out of 879 study participants. An increase of ES (even under basic AED therapy) was noted on days 14-21 after the start of RT course (i.e. between the 7 and 11th RT session) in 65 of 147 patients (44.2%). The administration of Valproic acid IV allowed all 65 patients to complete the course of RT/CRT. No adverse events (AE) associated with the use of Valproic acid were reported.

Conclusion: The study showed the high efficiency and safety of intravenous valproic acid in patients with ES (local and generalized) associated with a brain tumor during adjuvant radiotherapy/chemoradiotherapy (RT/CRT). The treatment should be accompanied by clinical, neurological and EEG monitoring.

Keywords: Valproic Acid; Valproate; Antiepileptic Drug; AED; Glial brain tumor; Epileptic Seizures; Status Epilepticus; Radiation Therapy


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Citation: Aleksandr S Shershever., et al. “Using Valproic Acid in Patients with Brain Tumor During Adjuvant Radiotherapy”. EC Neurology 12.1 (2020): 01-06.

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