Research Article
Volume 10 Issue 8 - 2018
Comparison of Reverse Nutech Functional Score with Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised to Evaluate Efficacy of Human Embryonic Stem Cell Therapy
Geeta Shroff*
Director, Nutech Mediworld, New Delhi, India
*Corresponding Author: Geeta Shroff, Director, Nutech Mediworld, New Delhi, India.
Received: April 20, 2018; Published: July 10, 2018
Citation: Geeta Shroff. “Comparison of Reverse Nutech Functional Score with Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised to Evaluate Efficacy of Human Embryonic Stem Cell Therapy”. EC Neurology 10.8 (2018): 671-680.
Abstract
Background: Amyotrophic lateral sclerosis (ALS) is a group of rare neurological diseases that mainly involve the nerve cells (neurons) responsible for controlling voluntary muscle movement. The present study aimed to evaluate the efficacy of hESC therapy using the Reverse Nutech Functional Score (RNFS) and ALS-Functional Rating Scale-Revised (ALS-FRS-R).
Materials and Methods: The study included 55 ALS patients. All the patients were investigated with routine diagnostic procedure for ALS. hESCs were administered via intramuscular, intravenous, supplemental routes including epidural and popliteal block, brachial plexus block, intrathecal, epidural catheter caudal and/or deep spinal muscle. Efficacy was assessed by scoring patients with RNFS and ALS-FRS-R.
Results: At the end of therapy, more patients with RNFS showed stability in affected parameters as compared to ALS-FRS-R. About 96.4% patients achieved stabilization when scored with RNFS and 89.1% patients achieved stabilization when scored with ALS-FRS-R with a single treatment session of stem cells.
Conclusion: hESCs may be beneficial in the treatment of patients with ALS as it stabilizes the condition. RNFS can be a unique tool to assess patients with ALS. Future studies are needed to substantiate the results.
Keywords: Amyotrophic Lateral Sclerosis; Motor Neurons; Neurodegenerative Disorder; Single Photon Emission Computed Tomography
Copyright: © 2018 Geeta Shroff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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