Research Article
Volume 10 Issue 8 - 2018
Huayutongluo Moxibustion Ameliorate Delayed Memory Dysfunction Via Promoting Neurogenesis and Angiogenesis of Hippocampus in a Vascular Dementia Rat Model
Yin-Qiu Fan1, Jun Yang2*, Jing-Cheng Cui1, Pin Wang3, Yue Li1 and Li Gui1
1Department of Postgraduate Education, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China
21st Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China
3Clinical Department of Acu-moxibustion and Orthopaedic, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China
*Corresponding Author: Jun Yang, 1st Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.
Received: March 19, 2018; Published: July 03, 2018
Citation: Jun Yang., et al. “Huayutongluo Moxibustion Ameliorate Delayed Memory Dysfunction Via Promoting Neurogenesis and Angiogenesis of Hippocampus in a Vascular Dementia Rat Model”. EC Neurology 10.8 (2018): 628-642.
Abstract
Neuron apoptosis due to ischemia has been considered to play one of the major roles in the pathogenesis of vascular dementia (VaD) and dysfunction of delay memory appears in the early phase of VaD. Previous study suggested that Huayutongluo Moxibustion could improve ischemia-induced cognitive impairments by stimulating angiogenesis in injured brain. However, whether delayed memory improvement is associated with neurogenesis and the effect of Huayutongluo Moxibustion on neurogenesis remains unclear. In this study, an animal model of VaD was established via bilateral common carotid arteries occlusion (BCCAo) to investigate the alteration of delayed memory, neurogenesis and angiogenesis. VaD rats suggested impairments in delayed memory as shown in Morris Water Maze. By NSCs+EPCs combinative implants or NSCs transplanted three days after ischemia injury and three courses of moxibustion treatment, VaD-induced delayed memory deficits were ameliorated. Expression of Nestin, DCX and CD34 significantly increased after treatment, which might contribute to the neurogenesis and angiogenesis in hippocampus. In addition, moxibustion significantly increased expression of Nestin, DCX and CD34 in NSCs+EPCs transplanted group of rats compared with those rats transplanted with NSCs. These findings suggested that Huayutongluo Moxibustion reversed VaD-induced delayed memory deficits, which might attribute to the promotion of neurogenesis and angiogenesis.
Keywords: Moxibustion; Vascular Dementia; Delayed Memory; Neurogenesis; Angiogenesis; Hippocampus
Copyright: © 2018 Jun Yang., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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