Review Article
Volume 12 Issue 1 - 2020
Iron Deposition in the Brain during the Aging Process and in Neurodegenerative Diseases: A Post-Mortem Review Study
Jacques L De Reuck*
Unitè 1171 “Degenerative and Vascular Cognitive Disorders”, Université de Lille 2, Lille, France
*Corresponding Author:Jacques L De Reuck, Unitè 1171 “Degenerative and Vascular Cognitive Disorders”, Université de Lille 2, Lille, France.
Received: November 20, 2019; Published: December 30, 2019




Abstract

Background and Purpose: The role of iron (Fe) accumulation in the brain is still a matter of debate. The present review examines all the available post-mortem data in the aging brain and in those with neurodegenerative diseases. 

Results: During normal aging there is a progressive increase of Fe, mainly in the basal ganglia. Most neurodegenerative diseases display Fe accumulation during the progression of their disorder. This is the most severe in frontotemporal lobar degeneration and to a lesser degree in amyotrophic lateral sclerosis and Parkinson’s disease. 

Conclusion: In all neurodegenerative diseases and during aging there is evidence that Fe accumulation contributes to further neuronal degeneration and promotes disease progression.

Keywords: Post-Mortem Brain Iron; Normal Aging; Alzheimer’s Disease; Frontotemporal Lobar Degeneration; Lewy Body Disease; Parkinson’s Disease; Progressive Supranuclear Palsy; Amyotrophic Lateral Sclerosis; Multiple System Atrophy

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Citation: Jacques L De Reuck. “Iron Deposition in the Brain during the Aging Process and in Neurodegenerative Diseases: A Post-Mortem Review Study”. EC Neurology 12.1 (2020): 01-09.

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