Short Communication
Volume 14 Issue 6 - 2022
Preventing Inflammaging with the Multitasking Vitamin K
Dilip S Mehta1 and Vladimir Badmaev2*
1Synergia Life Sciences Pvt. Ltd., Mumbai and Jogani Industrial Complex, V N Purav Marg, Chunabhatti, Mumbai, India
2Advisory Board of Synergia Life Sciences Pvt. Ltd.,, American Medical Holdings, Inc. Staten Island, NY, USA
*Corresponding Author: Vladimir Badmaev, American Medical Holdings, Inc. Staten Island, NY, USA.
Received: June 13, 2022; Published: June 18, 2022




Vitamin K denotes two fat-soluble vitamins, phylloquinone or vitamin K1, and menaquinone or vitamin K2 [1]. Plants and algae produce vitamin K1, and vitamin K2 is predominantly of microbial origin and comprises a family of molecules distinguished from K1 by unsaturated side chains of isoprenoid units varying in length from 1 to 14 repeats (hence, menaquinone-4, menaquinone-7, or MK-4, MK-7). The primary dietary form of vitamin K has been considered K1, whose most abundant source derives from green and leafy vegetables. In contrast, K2 occurs in animal products, meat, dairy, eggs, and fermented food, e.g., cheese, yogurt, and traditional Japanese food natto; it resides in the small and large intestine, where the intestinal microflora, mainly in the small intestine, synthesizes menaquinone-n.

References

  1. Karpiński M., et al. “Roles of Vitamins D and K, Nutrition, and Lifestyle in Low-Energy Bone Fractures in Children and Young Adults”. The Journal of the American College of Nutrition5 (2017): 399-412.
  2. Meredith L Zoch., et al. “New Insights into the Biology of Osteocalcin”. Bone 82 (2016): 42-49.
  3. Vaidya R., et al. “Insufficiency in the Indian Population: Pilot Observational Epidemiology Study”. JMIR Public Health Surveillance 8.2 (2022): e31941.
  4. Knapen MH., et al. “Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial”. Thrombosis and Haemostasis5 (2015): 1135-1144.
  5. Pan MH., et al. “Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro”. Journal of Medicinal Food7 (2016): 663-669.
  6. Dilip S Mehta., et al. “Randomized Controlled Trial of the Antinociceptive Effect of Menaquinone-7 (MK-7) in Patients with Peripheral Neuropathy”. EC Neurology8 (2021): 01-10.
  7. Saad FA. “Novel insights into the complex architecture of osteoporosis molecular genetics”. Annals of the New York Academy of Sciences1 (2020): 37-52.
  8. Wu WJ., et al. “The inhibitory effect of vitamin K on RANKL-induced osteoclast differentiation and bone resorption”. Food and Function10 (2015): 3351-3358.
  9. Wu WJ., et al. “A comparatively study of menaquinone-7 isolated from Cheonggukjang with vitamin K1 and menaquinone-4 on osteoblastic cells differentiation and mineralization”. Food and Chemical Toxicology 131 (2019): 110540.
  10. Ravishankar B., et al. “Safety assessment of menaquinone-7 for use in human nutrition”. Journal of Food and Drug Analysis1 (2015): 99-108.
Citation: Dilip S Mehta and Vladimir Badmaev. “Preventing Inflammaging with the Multitasking Vitamin K”. EC Neurology 14.6 (2022): 33-35.

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