Mini Review
Volume 14 Issue 6 - 2022
How to Diagnose Clinically with Certainty the Ehlers-Danlos Disease

Claude Hamonet1,2*, Stanislas Pommeret3, Sabine Pommeret4, Sacha Guilhaumou5, Régine Brissot2, Richard Amoretti6, Chantal-Marié Tanay7 and Arnaud Métlaine8

1Université Paris-Est-Créteil, France

2Centre de Santé EllaSanté, Paris, France

3Société Chimique de France, Paris

4Groupe d’Etude et de Recherche du Syndrome d’Ehlers-Danlos (GERSED), France

5Faculté de Pharmacie de Paris, France

6Centre Médical Integrative Systemic Medicine (ISM), Boulogne, France

7Bayeux, France

8Centre de Référence Maladies Rares du Sommeil et de la Vigilance, Hôpital Hôtel-Dieu, Paris, France

*Corresponding Author: Claude Hamonet, Professor, University Paris-East-Creteil, France.
Received: April 07, 2022; Published: May 28, 2022


Ehlers-Danlos is a hereditary disease of the connective tissues responsible for numerous clinical manifestations due to their fragility and dysproprioception, the origin of which is the distortion of the signals that these tissues send to a nervous system that is spared by the pathological process. The frequency of this disease, which is transmitted to all the children of an affected person, is very underestimated and could concern 2% of the population worldwide.

We were able to identify 79 signs in total. We chose 9 signs among the 20 most frequent signs for their representativeness of tissue fragility or dysproprioception, namely joint pain, fatigue, clumsiness, joint instability, changes in the structure of the skin (thin, stretchable or fragile), joint hyperlaxity, gastroesophageal reflux disease, frequent bruising, hyperacusis. The presence of these 9 signs was sought in two control groups, a first one of 826 "normal" subjects assessed during a systematic occupational medicine consultation and a second one of 206 patients consulting a general practitioner or a specialist without preliminary diagnosis. It is observed that 98% of the 853 patients affected by the disease have at least 5 of these 9 signs but that 99.6% of the 826 normal subjects and 98.1% of the 206 consultant patients do not have them. Diagnosing Ehlers-Danlos disease is therefore possible with certainty by a clinical examination that highlights at least 5 of the 9 signs that we have described in this work.

Keywords: Ehlers-Danlos; Hereditary Disease; Hyperlaxity; Multiple Pain; Proprioception; Dystonia; Mental Hyperactivity; Working Memory; Parental Violence; Arterial Aneurysm; Spontaneous Fractures; Diabetes Insipidus


  1. Hamonet C. “La maladie oubliée par la médecine” (“The Disease forgotten by medicine”). l’Harmattan Paris 2019 (2020).
  2. Hamonet C., et al. “Ehlers-Danlos Syndrome (EDS) to Clinical Diagnosis. A Prospective Study of 853 Patients”. EC Neurology6 (2018).
  3. Cypel D. “Gleno-humeral abduction measurement in patients with Ehlers-Danlos syndrome”. Orthopaedics and Traumatology: Surgery and Research2 (2019): 287-290.
  4. Hamonet C., et al. “Clinical diagnosis of Ehlers-Danlos syndrome. New fundamental perspectives”. International symposium on Ehlers-Danlos syndromes, Ghent, Belgium (2012).
  5. Hamonet C., et al. “Ehlers-Danlos et fausses accusations de maltraitance”. Gazette du Palais8 (2019): 19.
  6. Hamonet C., et al. “Bone fragility in infants with Ehlers-Danlos syndrome, From misdiagnosis to miscarriage of justice by false accusation of child abuse”. Symposium "Ehlers-Danlos. Cognitivity and Psychopathology", Hôpital de la Salpetrière, Paris (2018).
Citation: Claude Hamonet., et al. “How to Diagnose Clinically with Certainty the Ehlers-Danlos Disease”. EC Neurology 14.6 (2022): 28-32.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

September Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the September issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before October 06, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.