Review Article
Volume 14 Issue 5 - 2022
Approach to the Neuropsychiatric Sequelae of the Post-Covid-19 Syndrome
Juan Enrique Bender Del Busto1*, Marcel D Mendieta Pedroso2, Isairis González López3 and Liuba Hernández Toledo4
1Neurology Department, International Center of Neurological Restoration, Cuba
2Internal Medicine Department of Leopoldito Martínez Hospital, San José de las Lajas, Cuba
3Physiatry Department, O. Sanchez Polyclinic of Mayabeque, Cuba
4Nursing Department, International Center of Neurological Restoration (CIREN), Cuba
*Corresponding Author: Juan Enrique Bender Del Busto, Neurology Department, International Center of Neurological Restoration, Cuba.
Received: January 25, 2022; Published: April 28, 2022




Abstract

The SARS-CoV-2 coronavirus was first detected in December 2019 in the city of Wuhan, China, and is the seventh coronavirus known to infect humans. The disease has a wide spectrum of clinical presentation, ranging from asymptomatic to critical infection, and has become the top priority for the years 2020 - 2021. Post-acute symptoms of COVID-19 have been increasingly reported as the pandemic progresses. To date, more than 50 long-term effects have been identified, including signs, symptoms, laboratory and imaging parameters, and despite extensive work, the lasting effects of the disease have not yet been fully elucidated. This document aims to make an analytical summary of the available scientific evidence on the long-term affectation of the nervous system by SARS-CoV-2. To elaborate it, the Google Academic search engine and the descriptors COVID-19, SARS-CoV-2, neuropsychiatric manifestations/ complications and post-covid-19 syndrome were used. The Medline, Scielo, Scopus and Medscape databases were used. The definitions described for the Post-Covid Syndrome were reviewed, as well as the general clinical aspects, neuropsychiatric aspects and the general therapeutic approach. It is concluded that it is important to know that patients affected by COVID-19 may present clinical manifestations after the acute phase, which make up the post-COVID syndrome, in order to develop follow-up and treatment plans for these patients.

Keywords: SARS-Cov-2 Coronavirus; Post-Covid-19 Syndrome; Neuropsychiatric Aspects; Therapeutic Approach

References

  1. Sisó-Almirall A., et al. “Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona”. PLoS One8 (2020): e0237960.
  2. Gutiérrez BD., et al. “Efectos a largo plazo de la COVID-19: una revisión de la literature”. Acta Médica Grupo Angeles3 (2021): 421-428.
  3. Lopez-Leon S., et al. “More than 50 Long-term effects of COVID-19: a systematic review and meta analysis”. Med Rxiv (2021).
  4. Ståhlberg M., et al. “Síndrome de taquicardia post-Covid-19: un fenotipo distinto del síndrome de Covid-19 post-agudo”. The American Journal of Medicine (2021).
  5. Carfì A., et al. “Persistent Symptoms in Patients After Acute COVID-19”. The Journal of the American Medical Association (2020).
  6. Carod-Artal FJ. “Síndrome post-COVID-19: epidemiología, criterios diagnósticos y mecanismos patogénicos implicados”. Revue Neurologique 72 (2021): 384-396.
  7. Greenhalgh T and Knight M. “Long COVID: A Primer for Family Physicians”. American Family Physician12 (2020): 716-717.
  8. Callard F and Perego E. “How and why patients made Long Covid”. Social Science and Medicine 268 (2021): 113426.
  9. Greenhalgh T., et al. “Management of post-acute covid-19 in primary care”. BMJ 370 (2020): m3026.
  10. Centers for Disease Control and Prevention. Duration of isolation and precautions for adults with COVID-19 (2020).
  11. NICE panel expert. COVID-19 rapid guideline: managing the long-term effects of COVID-19 (2020).
  12. Boix V and Merino E. “Síndrome post-COVID. El desafío continua”. Medicina Clínica (2020).
  13. NIHR Living with covid-19. A dynamic review of the evidence around ongoingcovid-19 symptoms (often called long covid) (2020).
  14. Townsend L., et al. “Persistent poor health post-COVID-19 is not associated with respiratory complications or initial disease severity”. Annals of the American Thoracic Society6 (2021): 997-1003.
  15. Pun BT., et al. “Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults”. Critical Care Medicine1 (2019): 3-14.
  16. Stam HJ., et al. “Covid-19 and post intensive care syndrome: a call for action”. Journal of Rehabilitation Medicine4 (2020): jrm 00044.
  17. McInnes IB. “COVID-19 and rheumatology: first steps towards a different future?” Annals Rheumatic Diseases 79 (2020): 551-552.
  18. Rogers JP., et al. “Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic”. Lancet Psychiatry 7 (2020): 611-627.
  19. Siow I., et al. “Stroke as a neurological complication of COVID-19: a systematic review and meta-analysis of incidence, outcomes and predictors”. Journal of Stroke and Cerebrovascular Diseases 30 (2021): 105549.
  20. Pezzini A and Padovani A. “Lifting the mask on neurological manifestations of COVID-19”. Nature Reviews Neurology11 (2020): 636-644.
  21. Taquet M., et al. “6-month neurological and psychiatric outcomes in 236379 survivors of COVID-19: a retrospective cohort study using electronic health records”. Lancet Psychiatry 8 (2021): 416-427.
  22. Salmon-Ceron D., et al. “APHP COVID-19 research collaboration. Clinical, virological and imaging profile in patients with prolonged forms of COVID-19: a cross-sectional study”. Journal of Infection 82 (2021): e1-e4.
  23. Post COVID-19 condition: WHO supports standardization of clinical data collection and reporting (2021).
  24. Disser NP., et al. “Musculoskeletal Consequences of COVID-19”. Journal of Bone and Joint Surgery American14 (2020): 1197-1204.
  25. Griffith JF. “Musculoskeletal complications of severe acute respiratory syndrome”. Seminars in Musculoskeletal Radiology5 (2011): 554-560.
  26. Zhao Y-M., et al. “Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery”. EClinical Medicine 25 (2020): 100463.
  27. Zhang L., et al. “Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis”. PLoS One10 (2019): e0223185.
  28. Alemanno F., et al. “COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience”. PLoS One2 (2021): e0246590.
  29. Ortelli P., et al. “Neuropsychological and neurophysiological correlates of fatigue in post-acute patients with neurological manifestations of COVID-19: Insights into a challenging symptom”. Journal of the Neurological Sciences 420 (2021): 117271.
  30. Needham E., et al. “Mononeuritis multiplex: an unexpectedly frequent feature of severe COVID-19”. Journal of Neurology (2020): 1-5.
  31. Raahimi MM., et al. “Late onset Guillain-Barré syndrome following SARTS-CoV-2 infection: part of "long COVID-19 syndrome?” BMJ Case Reports1 (2021): e240178.
  32. Christie F., et al. “Meralgia paraesthetica in intensive care unit survivors of COVID-19”. Anaesthesia (2020).
  33. Lee AM., et al. “Stress and psychological distress among SARS survivors 1 year after the outbreak”. The Canadian Journal of Psychiatry4 (2007): 233-240.
  34. Sahoo PR., et al. “Evolution of olfactory and gustatory dysfunctions in COVID-19 patients in India”. European Archives of Oto-Rhino-Laryngology (2021): 1-7.
  35. Brito-Zerón P., et al. “Manifestaciones persistentes de la COVID-19. Guía de práctica clínica. 1a edition”. Barcelona: Sociedad Catalana de Medicina Familiar i Comunitària (CAMFiC) (2020): 1-43.
  36. Vindegaard N and Benros ME. “COVID-19 pandemic and mental health consequences: Systematic review of the current evidence”. Brain, Behavior, and Immunity 89 (2020): 531-542.
  37. Sher L. “Are COVID-19 survivors at increased risk for suicide?” Acta Neuropsychiatr 32 (2020): 270.
  38. Moldofsky H and Patcai J. “Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study”. BMC Neurology 11 (2011): 37.
  39. Rodríguez-Quiroga A., et al. “COVID-19 y salud mental”. Medicine 23 (2020): 1285-1296.
  40. O’Rourke MC., et al. “Suicide screening and prevention”. In: StatPearls. Treasure Island (2020).
  41. Wu Yeshun., et al. “Nervous system involvement after infection with COVID-19 and other coronaviruses”. Brain, Behavior, and Immunity (2020).
  42. Troyer EA., et al. “Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms”. Brain, Behavior, and Immunity (2020).
  43. Pérez A., et al. “Primer informe en Cuba de trastorno psicótico posterior a COVID-19. Informe de caso”. Acta Médica del Centro3 (2021).
  44. Taquet M., et al. “Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA”. Lancet Psychiatry 8 (2021): 130-140.
  45. Arango C. “Lessons learned from the coronavirus health crisis in Madrid, Spain: How COVID-19 has changed our lives in the last two weeks”. Biological Psychiatry (2020).
  46. Greenberg N., et al. “Managing mental health challenges faced by healthcare workers during covid-19 pandemic”. BMJ 368 (2020): m1211.
  47. Varatharaj A., et al. “Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study”. Lancet Psychiatry 7 (2020): 875-882.
  48. Liguori C., et al. “Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection”. Brain, Behavior, and Immunity 88 (2020): 11-16.
  49. Guía Clínica para la atención al paciente Long COVID / COVID (2021).
  50. Rozo AL., et al. “IX. Síndrome Post COVID-19: complicaciones tardías y rehabilitación. Suplemento 1 Consenso Colombiano SARS-CoV-2/COVID-19”. Tercera Edición (2021).
Citation: Juan Enrique Bender Del Busto., et al. “Approach to the Neuropsychiatric Sequelae of the Post-Covid-19 Syndrome”. EC Neurology 14.5 (2022): 55-63.

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