Research Article
Volume 14 Issue 5 - 2022
Recurrence of Surgically Treated Meningiomas: Experience of a Single Brazilian Tertiary Center with 757 Consecutive Tumors
Benedicto Oscar Colli1*, Hélio Rubens Machado1, Carlos Gilberto Carlotti Junior1, João Alberto Assirati Junior1, Ricardo Santos de Oliveira1, Guilherme Gozzoli Podolsky Gondim1, Antonio Carlos dos Santos2, Luciano Neder3 and Fabiano Saggioro3
1Division of Neurosurgery, Department of Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil
2Department of Medical Image, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Brazil
3Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Brazil
*Corresponding Author: Benedicto Oscar Colli, Division of Neurosurgery, Department of Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Received: March 14, 2022; Published: April 27, 2022




Abstract

Background: Meningiomas are the most common tumors of the central nervous system. Despite being mostly benign, some of them can recur even when totally resected. We aimed to determine the surgical/tumor characteristics of recurrence in meningiomas.

Methods: This was a retrospective analysis of nongenetic-molecular surgical tumor characteristics that influenced recurrence in 757 operated meningiomas.

Results: Recurrences predominated in males between 0-9-years-old and in tumors subtotally and partially resected, with the rates being similar for tumors of convexity and of the skull base. Recurrences occurred between 1-203 months and at rates of 33%, 64%, and 95.6% at 2, 5, 10, and 20 years, respectively. There was a tendency to observe fewer recurrences in the most recent decades for totally resected tumors. In intracranial tumors, recurrences occurred in 13.6%, 33.8%, and 33.3% of total, subtotal, and partial tumor resections, respectively. This correlated to 12.5%, 17.6%, 34.6%, and 32.9% of cases with Simpson grades I, II, III, and IV resections, respectively. There was two recurrences (2/34=5.8%) among spinal tumors. Recurrences increased by features of histopathological World Health Organization grades (14.6%, 41.8%, and 50.0% for grades I, II, and III, respectively).

Conclusions: Over time, meningiomas exhibited a tendency toward recurrence. Extension of the resection, histological grade, tumor size, and age were independent factors for recurrence in patients treated exclusively by surgery, as has been observed in other large studies. In addition, the male sex and atypia in histological grade I tumors were identified as being independent factors for recurrence. 

Keywords: Meningiomas; WHO Histopathological Grades; Surgical Treatment; Extent of Resection; Recurrences

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Citation: Benedicto Oscar Colli., et al. “Recurrence of Surgically Treated Meningiomas: Experience of a Single Brazilian Tertiary Center with 757 Consecutive Tumors”. EC Neurology 14.5 (2022): 16-31.

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