Review Article
Volume 14 Issue 3 - 2022
A Desktop Primer and Practical Review of Cannabis-Containing Compounds and Their Entourage Effects
Nicholas A Kerna1,2*, John V Flores3,4, Sudeep Chawla5, Stephen M Brown6, Joseph Anderson II7, ND Victor Carsrud8, Hilary M Holets3,4, Rashad Roberson9, Uzoamaka Nwokorie10 and Kevn D Pruitt11,12
1SMC, Medical Research, Thailand
2First InterHealth Group, Thailand
3Beverly Hills Wellness Surgical Institute, USA
4Orange Partners Surgicenter, USA
5Chawla Health & Research, USA
6International University of Health Sciences, St. Kitts
7International Institute of Original Medicine, USA
8Lakeline Wellness Center, USA
9Georgetown American University, College of Medicine, Guyana
10University of Washington, USA
11Kemet Medical Consultants, USA
12PBJ Medical Associates, LLC, USA
*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500.
Received: November 19, 2021; Published: February 28, 2022




Abstract

Cannabis sativa is one of the first domesticated plants known to humankind for its numerous psychological, physical, and emotional benefits. Its first use was reported in 2600 BCE in Chinese Pharmacopoeias. Cannabis subspecies hemp and marijuana are widely studied extracts. It is a complex plant with specific constituents acting synergistically. The discovery of the plant’s numerous compounds led to another discovery—that of the endocannabinoid system (ECS), which is widely distributed in the human brain and body. The ECS is responsible for various physiological and psychological effects. However, an increase in epidemiological studies is associated with dose-increasing psychotic disorders, raising significant concern among researchers and physicians. Research began on hundreds of cannabinoids contained in the cannabis plant, leading to the detection of CB1 and CB2 receptors—following the characterization of the ECS in the human body. Specific chemicals express synergistic effects, known particularly as “entourage effects”. The concerted effect of chemical constituents of cannabis enhance the overall pharmacological properties of the plant. This entourage effect has been supported by various studies. However, a few studies debunk the construct of cannabis’ entourage effects. Recent changes in the US FDA Legalization and Scheduled Drug Act are facilitating research on the cannabis plant and compounds to explore therapeutic potential.

Keywords: Cannabidiol; Cannabinol; GABA; Phytocannabinoids; Sativa; Sleep Disorder; Terpenes; Tetrahydrocannabinol

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Citation: Kerna NA, Flores JV, Chawla S, Brown SM, Anderson II J, Carsrud NDV, Holets HM, Roberson R, Nwokorie U, Pruitt KD. “A Desktop Primer and Practical Review of Cannabis-Containing Compounds and Their Entourage Effects”. EC Neurology 14.3 (2022): 49-57.

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