Research Article
Volume 14 Issue 3 - 2022
Catheterization of the Ostium of the Ophthalmic Artery for Intra-Arterial Chemotherapy in Retinoblastoma: Incidence of Reflux and its Impact on Treatment Outcome
Márcio Chaves Pedro Marques1,2*, Igor Campostrini Pagiola1,2, Michel Eli Frudit1, Luiz Fernando Teixeira2, Sidnei Epelman2 and Nitamar Abdala1
1Escola Paulista de Medicina, Federal University of São Paulo, São Paulo Brazil
2Hospital Santa Marcelina, São Paulo Brazil
*Corresponding Author: Márcio Chaves Pedro Marques, Escola Paulista de Medicina, Federal University of São Paulo and Hospital Santa Marcelina, São Paulo Brazil.
Received: December 30, 2021; Published: February 25, 2022




Abstract

Purpose: To ascertain the impact of reflux of chemotherapeutic agent into the internal carotid artery, a known complication of selective catheterization of the ostium of the ophthalmic artery for intra-arterial chemotherapy, on treatment outcomes in retinoblastoma.

Methods: All patients with retinoblastoma who underwent endovascular treatment at an interventional neuroradiology center between January 2012 and November 2019 were retrospectively analyzed. Demographic data, type of retinoblastoma, number of drugs used, catheterization sites, enucleation rate, and perioperative complications were recorded and compiled.

Results: Five hundred and six cycles of intra-arterial chemotherapy were performed in 113 patients (134 eyes). Ostial catheterization was performed in 370 cycles (73%), with reflux to the internal carotid artery in 152 (30%). The globe preservation rate was 72%. The complication rate was 6.91%. The most severe complication was autonomic cardiorespiratory reflex reaction, which occurred in 1.97% of cycles.

Conclusion: In children undergoing intra-arterial chemotherapy for retinoblastoma, selective catheterization of the ostium of the ophthalmic artery (OA) with reflux of chemotherapeutic agent into the internal carotid was frequent and had no impact on the response to treatment.

 

Keywords: Retinoblastoma; Intra-Arterial Chemotherapy; Endovascular Treatment; Ophthalmic Artery

References

  1. Kivela T. “The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death”. British Journal of Ophthalmology 93 (2009): 1129-1131.
  2. Macklin MT. “A study of retinoblastomaa in Ohio families”. Acta Genetica et Statistica Medica 7 (1957): 296-297.
  3. Yousef YA., et al. “Intra-arterial Chemotherapy for Retinoblastoma: A Systematic Review”. JAMA Ophthalmology 134 (2016): 584-591.
  4. Reese AB., et al. “Treatment of retinoblastoma by radiation and triethylenemelamine”. AMA Archives of ophthalmology 53 (1954): 505-513.
  5. Eng C., et al. “Mortality from second tumors among long-term survivors of retinoblastoma”. Journal of the National Cancer Institute 85 (1993): 1121-1128.
  6. Wong FL., et al. “Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk”. The Journal of the American Medical Association 278 (1997): 1262-1267.
  7. Epelman S. “Preserving vision in retinoblastoma through early detection and intervention”. Current Oncology Reports 14 (2012): 213-219.
  8. Ferris III FL and Chew EY. “A new era for the treatment of retinoblastoma”. Archives of Ophthalmology 114 (1996): 1412.
  9. Chan HS., et al. “Chemotherapy for retinoblastoma”. Ophthalmology Clinics of North America 18 (2005): 55-63.
  10. Murphree AL. “Intraocular retinoblastoma: the case for a new group classification”. Ophthalmology Clinics of North America 18 (2005): 41-53.
  11. Berry JL., et al. “Long-term outcomes of Group D eyes in bilateral retinoblastoma patients treated with chemoreduction and low-dose IMRT salvage”. Pediatric Blood and Cancer 60 (2013): 688-693.
  12. Gobin YP., et al. “Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience”. Archives of ophthalmology 129 (2011): 732-737.
  13. Shields CL., et al. “Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma”. Ophthalmology 121 (2014): 1453-1460.
  14. Abramson DH., et al. “Ophthalmic artery chemosurgery for eyes with advanced retinoblastoma”. Ophthalmic Genetics 38 (2017): 16-21.
  15. Kiratli H., et al. “Retrospective analysis of primarily treated group D retinoblastoma”. Graefe's Archive for Clinical and Experimental Ophthalmology 256 (2018): 2225-2231.
  16. Francis JH., et al. “Ten-year experience with ophthalmic artery chemosurgery: Ocular and recurrence-free survival”. PLoS One 13 (2018): e0197081.
  17. Munier FL., et al. “First-line intra-arterial versus intravenous chemotherapy in unilateral sporadic group D retinoblastoma: evidence of better visual outcomes, ocular survival and shorter time to success with intra-arterial delivery from retrospective review of 20 years of treatment”. British Journal of Ophthalmology 101 (2017): 1086-1093.
  18. Chen M., et al. “Outcome of intra-arterial chemotherapy for retinoblastoma and its influencing factors: a retrospective study”. Acta Ophthalmologica 95 (2017): 613-618.
  19. Michaels ST., et al. “Selective Ophthalmic Artery Infusion Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience”. Pediatric Hematology and Oncology 38 (2016): 65-69.
  20. Ravindran K., et al. “Intra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis”. Journal of NeuroInterventional Surgery 11 (2019): 1266-1272.
  21. Yamane T., et al. “The technique of ophthalmic arterial infusion therapy for patients with intraocular retinoblastoma”. The International Journal of Clinical Oncology 9 (2004): 69-73.
  22. Klufas MA., et al. “Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization”. American Journal of Neuroradiology 33 (2012): 1608-1614.
  23. The R Project for Statistical Computing (2017).
  24. Wickham H. “ggplot2: Elegant Graphics for Data Analysis”. Springer-Verlag, New York (2016).
  25. Pohlert T. “The Pairwise Multiple Comparison of Mean Ranks Package (PMCMR) (2014).
  26. Shields CL., et al. “The International Classification of Retinoblastoma predicts chemoreduction success”. Ophthalmology 113 (2006): 2276-2280.
  27. Suzuki S., et al. “Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis”. Ophthalmology 118 (2011): 2081-2087.
  28. Ong SJ., et al. “Selective ophthalmic arterial injection of melphalan for intraocular retinoblastoma: a 4-year review”. The Japanese Journal of Ophthalmology 59 (2015): 109-117.
  29. Abramson DH., et al. “Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide”. International Journal of Retina and Vitreous 3 (2017): 40.
  30. Abramson DH., et al. “A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results”. Ophthalmology 115 (2008): 1398-1404.
  31. Sweid A., et al. “Ophthalmic artery catheterization for retinoblastoma treatment: does reflux affect tumor response?” Journal of NeuroInterventional Surgery 12 (2020): 915-920.
  32. Abramson DH., et al. “Treatment of Retinoblastoma in 2015: Agreement and Disagreement”. JAMA Ophthalmology 133 (2015): 1341-1347.
  33. Shields CL., et al. “Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma”. The Asia-Pacific Journal of Ophthalmology 5 (2016): 97-103.
  34. Shields CL., et al. “Minimal exposure (one or two cycles) of intra-arterial chemotherapy in the management of retinoblastoma”. Ophthalmology 119 (2012): 188-192.
  35. Shields CL., et al. “Retinoblastoma Control With Primary Intra-arterial Chemotherapy: Outcomes Before and During the Intravitreal Chemotherapy Era”. Journal of Pediatric Ophthalmology and Strabismus 53 (2016): 275-284.
  36. Phillips TJ., et al. “Autonomic cardio-respiratory reflex reactions and superselective ophthalmic arterial chemotherapy for retinoblastoma”. Paediatric Anaesthesia 23 (2013): 940-945.
Citation: Márcio Chaves Pedro Marques., et al. “Catheterization of the Ostium of the Ophthalmic Artery for Intra-Arterial Chemotherapy in Retinoblastoma: Incidence of Reflux and its Impact on Treatment Outcome”. EC Neurology 14.3 (2022): 09-21.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 09, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.