Research Article
Volume 14 Issue 3 - 2022
Catheterization of the Ostium of the Ophthalmic Artery for Intra-Arterial Chemotherapy in Retinoblastoma: Incidence of Reflux and its Impact on Treatment Outcome
Márcio Chaves Pedro Marques1,2*, Igor Campostrini Pagiola1,2, Michel Eli Frudit1, Luiz Fernando Teixeira2, Sidnei Epelman2 and Nitamar Abdala1
1Escola Paulista de Medicina, Federal University of São Paulo, São Paulo Brazil
2Hospital Santa Marcelina, São Paulo Brazil
*Corresponding Author: Márcio Chaves Pedro Marques, Escola Paulista de Medicina, Federal University of São Paulo and Hospital Santa Marcelina, São Paulo Brazil.
Received: December 30, 2021; Published: February 25, 2022


Purpose: To ascertain the impact of reflux of chemotherapeutic agent into the internal carotid artery, a known complication of selective catheterization of the ostium of the ophthalmic artery for intra-arterial chemotherapy, on treatment outcomes in retinoblastoma.

Methods: All patients with retinoblastoma who underwent endovascular treatment at an interventional neuroradiology center between January 2012 and November 2019 were retrospectively analyzed. Demographic data, type of retinoblastoma, number of drugs used, catheterization sites, enucleation rate, and perioperative complications were recorded and compiled.

Results: Five hundred and six cycles of intra-arterial chemotherapy were performed in 113 patients (134 eyes). Ostial catheterization was performed in 370 cycles (73%), with reflux to the internal carotid artery in 152 (30%). The globe preservation rate was 72%. The complication rate was 6.91%. The most severe complication was autonomic cardiorespiratory reflex reaction, which occurred in 1.97% of cycles.

Conclusion: In children undergoing intra-arterial chemotherapy for retinoblastoma, selective catheterization of the ostium of the ophthalmic artery (OA) with reflux of chemotherapeutic agent into the internal carotid was frequent and had no impact on the response to treatment.


Keywords: Retinoblastoma; Intra-Arterial Chemotherapy; Endovascular Treatment; Ophthalmic Artery


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Citation: Márcio Chaves Pedro Marques., et al. “Catheterization of the Ostium of the Ophthalmic Artery for Intra-Arterial Chemotherapy in Retinoblastoma: Incidence of Reflux and its Impact on Treatment Outcome”. EC Neurology 14.3 (2022): 09-21.

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