Research Article
Volume 14 Issue 1 - 2022
Microglia and Astrocytes in Postmortem Human Brain Increase in Parallel with Aging
Anne K Vehmas*
Department of Pathology, Neuropathology Division, The Johns Hopkins University, School of Medicine, USA
*Corresponding Author: Anne K Vehmas, Department of Pathology, Neuropathology Division, The Johns Hopkins University, School of Medicine, USA.
Received: November 12, 2021; Published: December 30, 2021




Abstract

We showed previously significantly increased fractional areas (FA) of HLA- DR and GFAP immunoreactivities (microglia and astrocytes) in brains of patients with Alzheimer´s disease (AD). This prompted us to assess FA and qualitative alterations in HLA-DR, GFAP, amyloid-β-peptide (Aβ) and phospho-tau immunoreactivities during aging in human neocortex of 11 young (mean 26 years), 9 middle aged (mean 48 years) and 11 elderly (mean 82 years) healthy persons.

The mean FAs of HLA-DR and GFAP were similar in young and middle-aged persons, but significantly greater (p < 0.05 resp. <0.004) in young vs. elderly persons. In middle-aged vs. elderly persons only the increase in FA-GFAP reached significance (p < 0.001). while that in FA-HLA-DR did not. In the young microglia were located predominantly perivascularly, in the elderly widely in the neuropil. Aβ immunoreactivity did not appear until in middle- aged persons, tau-staining remained negative throughout.

In conclusion: Brain cells of innate immunity, microglia and astrocytes, increase during aging probably reflecting cumulative immunologically challenging events, including those of AD, possibly also compensating for their senescence and fading protective capacity.

Keywords: Microglia; Astrocytes; Inflammation; Aging; Senescence; Amyloid; β-peptide; Tau; Quantification

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Citation: Anne K Vehmas. “Microglia and Astrocytes in Postmortem Human Brain Increase in Parallel with Aging”. EC Neurology 14.1 (2022): 21-29.

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