Case Report
Volume 13 Issue 12 - 2021
Clinical Effects of rTMS on Long COVID Neuropsychiatric Symptoms: Report of Case Series
José Luis Guerrero Solano1,2,3,4*, Carlos Manuel Romero Sánchez5, Elena Molina Pacheco6 and Tomas Segura5,7
1Department of Clinical Neurophysiology, General University Hospital of Albacete, Albacete, Spain
2Department of Clinical Neurophysiology, Hospital Angeles Valle Oriente, San Pedro Garza García, México
3Centro de Neurociencias Cognitivas CoNoCe, Valencia, Spain
4Clínica de Rehabilitación Azorín, Albacete, Spain
5Department of Neurology, General University Hospital of Albacete, Albacete, Spain
6Department of Internal Medicine, General University Hospital of Villarrobledo, Villarrobledo and Faculty of Medicine, University of Castilla la Mancha, Albacete, Spain
7Instituto de Investigación en Discapacidades Neurológicas (IDINE), University of Castilla la Mancha, Albacete, Spain
*Corresponding Author: José Luis Guerrero Solano, Department of Clinical Neurophysiology, General University Hospital of Albacete, Albacete, Spain.
Received: October 22, 2021; Published: November 23, 2021




Abstract

Most of the patients who recover from COVID-19 acute infection will experience persistent peripheral and central neurological and psychiatric symptoms called long COVID, regardless of the severity of the initial infection. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation device, has shown to be a safe and effective tool to treat depression, chronic pain, fibromyalgia and fatigue syndrome among other neuropsychiatric disorders that seem to share some of the underlying mechanisms seen in long COVID. 20 - 30 high frequency rTMS over the left dorsolateral prefrontal cortex was performed in four patients suffering of long COVID using a H1 coil in one patient and a figure of eight coil in 3 patients. Fatigue severity scale, brain fog visual analogue scale, pain visual analogue scale, WHOQOL-BREF quality life scale and Beck depression inventory were measured prior, during and immediately after rTMS. After 20 - 30 sessions, rTMS showed significant beneficial effects on fatigue, pain, quality of life and cognitive but not on affective symptoms. No adverse events were reported on any of the patients.

Keywords: Repetitive Transcranial Magnetic Stimulation (rTMS); Transcranial Magnetic Stimulation (TMS); Deep TMS; Long COVID; COVID 19

Citation: José Luis Guerrero Solano., et al. “Clinical Effects of rTMS on Long COVID Neuropsychiatric Symptoms: Report of Case Series”. EC Neurology 13.12 (2021): 34-38.

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