Abstract

Importance: Deep Brain Stimulation [DBS] has been a breakthrough advancement in recent years in the treatment of Parkinson’s disease. The altercation still goes on the effectiveness of the unilateral and bilateral DBS but the patients in different stages of Parkinson’s disease have shown effective results with both unilateral and bilateral DBS.

Observations: Research and trials have shown the many beneficial outcomes of DBS in Parkinson's disease. These are pruning of motor fluctuation severity, a reduced daily dose of levodopa, and enhancement of sleep quality and cognitive functions. There are some disadvantages of DBS with the surgical procedure, implants, and their stimulation. These disadvantages can be conquered by advancements in the technology of DBS. The evolution in the DBS implants like connectivity of electrodes with automatic sensing technology, long battery life and connectivity with wifi can facilitate better outcomes of DBS in progressive neurodegenerative Parkinson's disease.

Conclusion: Motor symptoms of Parkinson’s disease and sleep quality have been seen to be improved with DBS. Negative symptoms like anhedonia, social withdrawal, etc. which are seen in patients with Parkinson’s disease do not show any reduction or improvement with DBS.

Keywords: Parkinson’s Disease (PD); Deep Brain Stimulation

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