Research Article
Volume 13 Issue 10 - 2021
Dissociation of Correlations Between Aggregation Indicators and the Number of Peripheral Blood Cells with Regenerative Potential Contributes to an Increase in Life Expectancy et Glioblastomas
Pedachenko EG1, Моrozov АM1, Gridina N Ya1*, Rozumenko VD1, Kot LA1, Ushenin Yu V2, Kliuchka VM1, Draguntsova NG1, Rozumenko AV1, Belousova AD1 and Biloshytsky VV1
1Institute of Neurosurgery n. A. P. Romodanova, Kyiv, Ukraine
2Institute of Semiconductor Physics n. V. E. Lashkaryova, Kyiv, Ukraine
*Corresponding Author: Gridina N Ya, Institute of Neurosurgery A. P. Romodanova, Kyiv, Ukraine.
Received: August 11, 2021; Published: September 28, 2021




Abstract

The work investigated the correlations between the indicators of blood cells aggregation, characterizing stage II inflammation, and their quantitative composition in the peripheral blood, in patients before and after surgery for the total removal of glioblastomas. A very high correlation coefficient was found in patients with preoperative glioblastomas. After total removal of the tumor, the indices of the number of blood cells and the level of cell aggregation lost reliable correlations on the 7th day after the operation. They were also absent in healthy individuals. It is assumed that the growth of a tumor in the body is to a certain extent due to the functioning of blood cells with a regenerative potential against the background of a pronounced inflammatory process, which is confirmed by high rates of correlations. The absence of such connections after removal of glioblastomas and in healthy individuals may contribute to a new approach to the development of a method for diagnosing malignant brain tumors, which is difficult due to the presence of the blood-brain barrier and the rapid development of edema in the perifocal areas of the brain. A significant decrease in the manifestations of the inflammatory process against the background of regeneration processes in the postoperative period, as well as high correlations between the cells themselves with a regenerative potential, restoring the cytoarchitectonics of brain tissues, can probably contribute to an increase in the life expectancy of patients with glioblastomas.

 Keywords: Glioblastomas; Inflammation; Blood Cells Number and Aggregation; Negative Correlation; Diagnostic Method; Increase in Life Expectancy.

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Citation: Gridina N Ya., et al. “Dissociation of Correlations Between Aggregation Indicators and the Number of Peripheral Blood Cells with Regenerative Potential Contributes to an Increase in Life Expectancy et Glioblastomas”. EC Neurology 13.10 (2021): 48-54.

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