Research Article
Volume 13 Issue 8 - 2021
Analogous Effects of Nicotine and Muscarine on the Curare-Sensitive/ Atropine-Insensitive Discharges of Identified Lymnaea Neurons
William Winlow1,2* and G Mishmast-Nehi3
1Department of Biology, University of Naples Federico II, Via Cintia 26, Naples, Italy
2Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom
3Department of Physiology, Zahedan Medical, University Zahedan, Iran
*Corresponding Author: William Winlow, Department of Biology, University of Naples Federico II, Via Cintia 26, Naples, Italy and Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom.
Received: June 08, 2021; Published: July 27, 2021


The effects of acetylcholine (ACh), its orthodox agonists and antagonists were tested on identified neurons associated with respiratory behaviour in the intact brain of Lymnaea stagnalis (L.) using intracellular microelectrodes. Drugs were bath applied. With one exception, ACh caused depolarization and increased spike frequency in the cell types studied. In most cells nicotine and muscarine usually had similar effects, exciting some and inhibiting others. Further unorthodox results were also found in that succinylcholine (SCh) acted more like a nicotinic agonist rather than an antagonist, as did arecoline. The muscarinic antagonist, atropine, had little or no effect on any of the cells studied. Sensitivity to ACh, nicotine and muscarine differ for different cells, and comparison of the effects of ACh, nicotine and muscarine suggest that some of the cholinoceptors studied resemble either conjoint receptors or multiple cholinoceptors on the same cell.

Keywords: Acetylcholine; Curare; Atropine; Nicotine; Muscarine; Succinylcholine; Arecoline; Identified Neurons; Lymnaea stagnalis (L.)


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Citation: William Winlow and G Mishmast-Nehi. “Analogous Effects of Nicotine and Muscarine on the Curare-Sensitive/Atropine-Insensitive Discharges of Identified Lymnaea Neurons”. EC Neurology 13.8 (2021): 44-55.

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