Review Article
Volume 13 Issue 8 - 2021
Pathological Expression and Circuits in Addiction and Mood Disorders: Informational Relation with the Brain and Info-Therapy
Florin Gaiseanu*
PhD, Science and Technology of Information Bucharest, Romania and Barcelona, Spain
*Corresponding Author: Florin Gaiseanu, PhD, Science and Technology of Information Bucharest, Romania and Barcelona, Spain.
Received: June 07, 2021; Published: July 22, 2021


Introduction: The relation between mind and body, particularly between pathological expression and brain supporting processes in addiction and mood disorders is not yet well understood, either in neurosciences and nor in neurology.

Aim: The aim of this paper is to contribute to a better understanding of the addiction and mood disorders in terms of informational processes in the brain and to propose supporting palliative/helping/preventive info-therapy for relapse avoidance.

Analysisof the pathological expression and circuits in addiction and mood disorders: It is shown that the pathological expression of addiction to alcohol/drugs/nicotine and mood - anxiety, depression, bipolar and schizophrenia disorders are related mainly to the excessive/insufficient stimulatory/inhibitory neurotransmission and to the impairment of some fundamental balancing YES/NO circuits including the limbic system, specifically amygdala, caudate-putamen, nucleus accumbens and hippocampus connected to prefrontal cortex, the area of judgment. The potential involvement of mitochondria in the energy imbalance and of the growth factor in mood disorders are also highlighted, and the importance of a fine-tuned/precise diagnostic revealed by the blood biomarker analysis is also pointed out. The main risk factor is associated with the genetic inheritance, but the influence of the external factors is also important.

Informational relation with the brain and info-therapy: The analysis allows to discuss the addiction and mood disorder from informational perspective, in correlation with the informational structure of the brain, consisting in seven main distinct functions supported by various zones, defined as: CASI (the centre of acquisition and storing of information), CDC (the centre of decision and command), IES (info-emotional system), MIS (the maintenance informational system), GTS (the genetic transmission system), IGG (info-genetic generator), IC (info-connection). In terms of information, the relation of addiction and mood disorders with the brain can be synthetized as following: (A) the dysfunctionality of the brain is mainly due to the imbalance of IES (stimulatory) vs. CASI/CDC (inhibitory) YES/NO role and of the stimulant/inhibitive neurotransmitters; (B) the susceptibility/vulnerability of addiction/mood disorders are mainly related with IGG; (C) the external stress and life conditions as informational stimuli/factors are related by epigenetic mechanisms, which determine the integration of information in genetic system of the brain.

Conclusion: The control of information in a selective way is a basis for a prevention/palliative info-therapy process, activating the involvement of the epigenetic mechanism to substitute the obsolete older stereotype patterned/"engraved" habits and the associated pathological expression.

Keywords: Pathological Expression; Mind Operability; Addiction; Mood Disorders; Susceptibility/Vulnerability; Prefrontal Cortex; Amygdala/Limbic System; Informational System; Epigenetic Info-Integration; Info-Therapy


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Citation: Florin Gaiseanu. “Pathological Expression and Circuits in Addiction and Mood Disorders: Informational Relation with the Brain and Info-Therapy”. EC Neurology 13.8 (2021): 24-35.

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