Guest Editorial
Volume 13 Issue 7 - 2021
Affectation of the Nervous System by Sars-Cov2 as a Health Problem
Juan Enrique Bender del Busto*
Philosopher Doctor, 2nd Degree Specialist in Neurology, Full Professor and Researcher, Consultant Professor, International Center of Neurological Restoration, Havana, Cuba
*Corresponding Author: Juan Enrique Bender del Busto, Philosopher Doctor, 2nd Degree Specialist in Neurology, Full Professor and Researcher, Consultant Professor, International Center of Neurological Restoration, Havana, Cuba.
Received: May 31, 2021;Published: June 30, 2021

Humanity faces a very difficult situation, since in December 2019 several patients with respiratory symptoms and pneumonia were notified in Wuhan (Hubei province, China) [1,2] but in which, in turn, other patients were implicated. organs and systems and among them, the nervous system and whose causative agent was a new coronavirus (2019-nCoV).

On February 11, 2020, it was named acute respiratory syndrome coronavirus 2 (SARS-CoV-2), being the seventh known coronavirus to infect humans [3,4].


    1. Wu F., et al. “A new coronavirus associated with human respiratory disease in China”. Nature 579 (2020): 265-269.
    2. Chen X and Yu B. “First two months of the 2019 Coronavirus Disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model”. Global Health Research and Policy 1 (2020): 1-9.
    3. Lippi A., et al. “SARS-CoV-2: at the crossroad between aging and neurodegeneration”. Movement Disorders (2020).
    4. Lahiri D and Ardila A. “COVID-19 Pandemic: A Neurological Perspective”. Cureus 4 (2020): e7889.
    5. Mao L., et al. “Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study”. SSRN Journal (2020).
    6. Baig AM., et al. “Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms”. ACS Chemical Neuroscience 7 (2020): 995-998.
    7. Serrano-Castro PJ., et al. “Influencia de la infeccion SARS-Cov2 sobre Enfermedades Neurodegenerativas y Neuropsiquiatricas: ¿Una pandemia demorada?” Neurolog´ıa (2020).
    8. World Health Organization. Coronavirus disease (COVID-19) pandemic. Geneva: WHO (2020).
    9. Jin H., et al. “Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists”. Stroke and Vascular Neurology (2020).
    10. WHO Cumulative number of reported probable cases of SARS (2003).
    11. Lyden P. “Temporary Emergency Guidance to US Stroke CentersVDuring the COVID-19 Pandemic On Behalf of the AHA/ASA Stroke Council Leadership (2020).
    12. Carod-Artal FJ. “Complicaciones neurológicas por coronavirus y COVID-19”. Revista de Neurología 70 (2020): 311-322.
    13. Talan J. “COVID-19: Neurologists in Italy to Colleagues in US: Look for Poorly Defined Neurologic Conditions in Patients with the Coronavirus”. Neurology Today (2020).
    14. Zhao K., et al. “Acute myelitis after SARS-CoV-2 infection: a case report”. Med Rxiv Preprint (2020).
    15. Poyiadji N., et al. “COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features”. Radiology (2020): 201187.
    16. Mao L., et al. “Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China”. JAMA Neurology (2020).
    17. León R., et al. “Afectación del sistema nervioso por la COVID-19”. Anales de la Academia de Ciencias de Cuba2 (2020).
    18. Helms J., et al. “Neurologic Features in Severe SARS-CoV-2 Infection”. The New England Journal of Medicine (2020).
    19. net. Beijing hospital confirms nervous system infections by novel coronavirus (2020).
    20. Moriguchi T., et al. “A first case of meningitis/encephalitis associated with SARS-Coronavirus-2”. International Journal of Infectious Diseases 94 (2020): 55-58.
    21. Bender J., et al. “Epilepsia y COVID-19”. Anales de la Academia de Ciencias de Cuba2 (2020).
    22. Karimi N., et al. “Frequent Convulsive Seizures in an Adult Patient with COVID-19: A Case Report”. Iranian Red Crescent Medical Journal3 (2020): e102828.
    23. Li Y., et al. “Acute cerebrovascular disease following COVID-19: a single, retrospective, observational study”. Lancet (2020).
    24. Guo T., et al. “Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19)”. JAMA Cardiology (2020).
    25. Bender J., et al. “Enfermedad cerebrovascular y COVID-19”. Anales de la Academia de Ciencias de Cuba2 (2020).
    26. Zhang Y., et al. “Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19”. The New England Journal of Medicine (2020).
    27. Guidon AC and Amato AA. “COVID – 19 and neuromuscular disorders”. Neurology22 (2020): 1-11.
    28. Association of British Neurologists. Association of British Neurologists guidance on COVID-19 for people with neurological conditions, their doctors and carers (2020).
    29. Butowt R and Bilinska K. “SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection”. ACS Chemical Neuroscience (2020).
    30. León R., et al. “Disfunción olfatoria y COVID-19”. Anales de la Academia de Ciencias de Cuba2 (2020).
    31. Menni C., et al. “Real-time tracking of self-reported symptoms to predict potential COVID-19”. Nature Medicine (2020).
    32. Lechien JR., et al. “Objective olfactory testing in patients presenting with sudden onset olfactory dysfunction as the first manifestation of confirmed COVID-19 infection”. Med Rxiv (2020).
    33. Troyer EA., et al. “Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms”. Brain, Behavior, and Immunity (2020).
    34. Kim JE., et al. “Neurological complications during treatment of middle east respiratory syndrome”. Journal of Clinical Neurology 13 (2017): 227-233.
    35. Tsai LK., et al. “Neuromuscular disorders in severe acute respiratory syndrome”. Archives of Neurology 61 (2004): 1669-1673.
    36. Kępińska AP., et al. “Schizophrenia and Influenza at the Centenary of the 1918-1919 Spanish Influenza Pandemic: Mechanisms of Psychosis Risk”. Frontiers in Psychiatry 11 (2020): 1-19.
    37. Bender JE., et al. “Manifestaciones psiquiátricas en relación con la infección por el SARS-CoV-2”. Anales de la Academia de Ciencias de Cuba3 (2020).
    38. Lai J., et al. “Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019”. JAMA Network Open 3 (2020): e203976.
    39. Mealer M., et al. “The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses”. Depress Anxiety12 (2009): 1118-1126.
    40. Arango C. “Lessons learned from the coronavirus health crisis in Madrid, Spain: How COVID-19 has changed our lives in the last two weeks. Biological Psychiatry, in press (2020): 12.
    41. American Psychiatric Association (APA). Manual diagnóstico y estadístico de los trastornos mentales. DSM-5. Editorial Médica Panamericana (2014): 3.
    42. Brooks SK., et al. “The psychological impact of quarantine and how to reduce it: rapid review of evidence”. Lancet 395 (2020): 912-920.
    43. Pandya A. “Psiquiatría de adultos en situación de desastre. En FOCUS, APA (Asociación de Psiquiatría Americana) Lifelong learning in Psychiatry. Trastorno por estrés postraumático y Psiquiatría de desastres (I). Washington DC and London, UK (2009).
    44. Yao H., et al. “Patients with mental health disorders in the COVID-19 epidemic”. The Lancet Psychiatry4 (2020): 21.
    45. Peña Koka X. “Ya se notan los efectos del confinamiento: depresión, estrés, insomnio y ansiedad. El confidencial. 26 marzo (2020).
    46. Arango C., et al. “Preventive strategies for mental health”. Lancet Psychiatry7 (2018): 591-604.
    47. Greenberg N., et al. “Managing mental health challenges faced by healthcare workers during covid-19 pandemic”. British Medical Journal 368 (2020): m1211.
    48. Severance EG., et al. “Inmunorreactividad del coronavirus en individuos con un inicio reciente de síntomas psicóticos”. Schizophr. Toro 37 (2011): 101-107.
    49. Valdes-Florido MJ., et al. “Reactive psychoses in the context of the COVID-19 pandemic: clinical perspectives from a case series, Revista de psiquiatrıa y salud mental (Barcelona) (2020).
    50. Rey PC. “Manifestaciones neuropsiquiátricas del Covid-19. Departamento de Salud Mental. Hospital de Clinicas "José de San Martín". Facultad de Medicina. Universidad de Buenos Aires (2020).
    51. Brauser D. “Depresión vinculada a neurodisfunción y lesiones cerebrales en la esclerosis multiple”. Medscape (2020).
Citation: Juan Enrique Bender del Busto. “Affectation of the Nervous System by Sars-Cov2 as a Health Problem”.EC Neurology 13.7 (2021): 60-64.

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