Review Article
Volume 13 Issue 7 - 2021
A Review Article on the Benefit of Melatonin in Ebola Virus Disease Treatment: A Summary of Available Evidence
Diriba Dereje1*, Urge Gerema2, Bekalu Getachew2 and Tesema Etefa2
1Department of Biomedical Sciences (Physiology), Institute of Health, Jimma University, Ethiopia
2Department of Biomedical Sciences (Anatomy), Institute of Health, Jimma University, Ethiopia
*Corresponding Author: Diriba Dereje, Department of Biomedical Sciences (Physiology), Institute of Health, Jimma University, Ethiopia.
Received: December 15, 2020; Published: June 23, 2021


Ebola virus disease (EVD) is a viral infectious having high mortality rate. But, there is no yet available proven and recommended treatment. A severe EVD is characterized by insobriety, severe hemorrhages, disseminated intravascular coagulation and multiple organ failure with the development of severe shock. Melatonin application may act on and prevent each of those pathological alterations caused by the EVD. Melatonin possesses pro- and anti-inflammatory properties, limit coagulation problems, can prevent the oxidative stress and inflammatory injury that occurs in the infected endothelial cells, decreases the symptoms, and increases the survival rate after Ebola virus infection. Further clinical trials are mandatory and recommended to explore melatonin side effects, benefits, food and drug interactions, and route of administrations in Ebola virus disease management and prevention of complications.

Keywords: Ebola Virus Disease; Melatonin; A Review


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Citation: Diriba Dereje., et al. “A Review Article on the Benefit of Melatonin in Ebola Virus Disease Treatment: A Summary of Available Evidence”. EC Neurology 13.7 (2021): 43-46.

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