Research Article
Volume 13 Issue 7 - 2021
Spinal Neurofibromas: Literature Review and Surgical Outcome
Farooq Azam1, Adnan Khaliq1*, Mumtaz Ali1 and Bipin Chaurasia2
1Department of Neurosurgery, MTI/Lady Reading Hospital, Peshawar, Pakistan
2Department of Neurosurgery, BSMMU, Bangladesh
*Corresponding Author: Adnan Khaliq, Department of Neurosurgery, MTI/Lady Reading Hospital, Peshawar, Pakistan.
Received: October 11, 2020; Published: June 22, 2021




Preface

Objective: To determine the overall clinical outcome, specific features of spinal neurofibromas following surgery.

Background: Among all primary spinal neoplasms, approximately one-third are neurofibromas. Its incidence, clinical presentation, operative techniques and outcome of surgical resection need be studied thoroughly.

Methodology: This Retrospective study was conducted in department of Neurosurgery Lady Reading Hospital Peshawar, Pakistan from January 2016 to December 2016. Medical records of patients was revised and searched. Inclusion criteria was all symptomatic newly diagnosed and recurrent spinal neurofibromas. Exclusion criteria was asymptomatic spinal neurofibromas found as incidental finding. Patients were followed upto 3 months post operatively. The demographic data, clinical, radiological and histological details of patients were analyzed to assess and evaluate the predictive factors that affect post-operative clinical outcome. Diagnosis was made on clinical features, contrast enhanced spinal magnetic resonance imaging (MRI) and confirmed by histopathology of the lesion. Gross Total Microsurgical resection was carried out in all cases through a posterior approach. Post-Operative assessment was done in terms of clinical, neurological improvement of symptoms and surgical complications.

Results: Total number of patients were (15) harboring spinal neurofibroma. Mean age was (55 years). There were (8) males and (7) females patients. Neurofibroma was found in cervical spine in 11 cases (72%) and in thoracic spine in 4 cases (28%). Fresh cases were (13) and recurrent cases were (2).

Clinical presentations of patients were gait disturbance 14 cases (93%), Motor deficit/weakness 12cases (80%), sensory deficit 12 cases (80%), radicular pain 9 cases (60%), local spinal pain in 7 cases (47%), sphincter dysfunction in 9 cases (60%). The most common site of spinal neurofibromas was cervical region. All tumors were intramural extramedullary. All patients were thoroughly observed for 12 months. Post-operative neurological improvement was observed in 13 patients (87%). There was no operative mortality. None of the patient was subjected to adjuvant radiotherapy.

Conclusion: Spinal neurofibromas are benign tumors. Surgical excision can be safely done without having any post-operative deficits. Availability of many different tools and good microscope has made complete removal of tumors with no further recurrences.

 

Keywords: Neurofibroma; Spinal Tumors; Surgical Outcome

References

  1. Herbert B Newton. “Overview of Spinal Cord Tumor Epidemiology”. Handbook of Neuro-Oncology Neuroimaging (2016).
  2. Zhao B and Xu J. “Extensive posterolateral exposure and total removal of the giant extraforaminal dumbbell tumors of cervical spine: surgical technique in a series of 16 patients”. The Spine Journal 9 (2009): 822-829.
  3. Watanabe M., et al. “Upper cervical spinal cord tumors: review of 13 cases”. The Journal of Orthopaedic Science 14 (2009): 175-181.
  4. Herbert B Newton. “Overview of Pathology and Treatment of Primary Spinal Cord Tumors”. Handbook of Neuro-Oncology Neuroimaging (2016).
  5. Seppala MT., et al. “Long-term outcome after I removal of spinal schwannoma: a clinicopathological study of 187 cases”. Journal of Neurosurgery 83 (2012): 621.
  6. Conti P., et al. “Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literature”. Surgical Neurology 61 (2010): 34.
  7. Celli P., et al. “Spinal extradural schwannoma”. Journal of Neurosurgery Spine 2 (2005): 447-456.
  8. Helenius IJ., et al. “Outcomes of spinal fusion for cervical kyphosis in children with neurofibromatosis”. Journal of Bone and Joint Surgery 98.21 (2016): e95.
  9. Safaee MM., et al. “Neurological outcomes and surgical complications in 221 spinal nerve sheath tumors”. Journal of Neurosurgery: Spine1 (2017): 103-111.
  10. Chaurasia B., et al. “Bilateral Symmetric Dumbbell C1-C2 Ganglioneuroma in Neurofibromatosis Type 1 Patient Causing Spastic Quadriparesis”. Journal of Spine Surgery3 (2018): 138-143.
Citation: Adnan Khaliq., et al. “The Vitiated Highbrow- Brain in COVID-19”. EC Neurology 13.5 (2021): 37-42.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 14, 2021.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk