Case Report
Volume 13 Issue 7 - 2021
Bradykinin-Mediated Angioedema Related to Alteplase Successfully Treated by Frozen Fresh Plasma: First Case Report with Literature Review
Narjes M1*, Sana K2, Neveen F5, Bashir I5, Hani K3, Ahmed M4 and Hassen M3
1Internal Medicine, Armed Forces Hospital Wadi Al Dawasir, Saudi Arabia
2ICU Department, Armed Forces Hospital Wadi Al Dawasir, Saudi Arabia
3Surgical Department, Armed Forces Hospital Wadi Al Dawasir, Saudi Arabia
4Family Medicine Department, Armed Forces Hospital Wadi Al Dawasir, Saudi Arabia
5Continuous Quality Improvement and Patient Safety Department, Armed Forces Hospital Wadi Al Dawasir, Saudi Arabia
*Corresponding Author: Narjes M, Internal Medicine, Armed Forces Hospital Wadi Al Dawasir, Saudi Arabia.
Received: March 31, 2020; Published: June 30, 2021




Abstract

Angioedema can be a life-threatening complication after thrombolytic therapy Alteplase. The incidence is 1-5%, the risk of developing bradykinin-mediated angioedema is multiplied by 6 in patient on angiotensin converting enzyme inhibitor. Most therapeutic options are ineffective or expensive and not available. FFP is known as effective treatment for bradykinin- mediate angioedema since 1969 but never reported in case of angioedema rtPA induced. We report a case of 60 year old patient with history of hypertension treated with angiotensin converting enzyme inhibitor, who developing severe bradykinin-mediates angioedema 10 min after the end of thrombolytic therapy. The patient was treated successfully with FFP. We are reporting this case to increase the awareness of physicians and to widen their therapeutic options when encountering this clinically significant condition.

Keywords: Angioedema; Frozen Fresh Plasma; Thrombolysis Therapy; Stroke

References

  1. YX Wa Ng and YQ LI Y Chen. “Analysis of related factors of orolingual angioedema after rt-PA intravenous thrombolytic therapy”. European Review for Medical and Pharmacological Sciences 22 (2018): 1478-1484.
  2. Correia AS., et al. “Orolingual angiodema as-sociated with alteplase treatment of acute stroke: Areappraisal”. Journal of Stroke and Cerebrovascular Diseases (2015): 31-40.
  3. Aydın Talip Yıldoğan., et al. “Orolingual Angioedema After Intravenous Tissue Plasminogen Activator in a Patient with Insular Cortex Ischemia: A Case Report”. Journal of Neurological Sciences 26 (2020): 346-348.
  4. Mohamed Shirazy., et al. “A Case of Oropharyngeal Angioedema Following Intravenous Recombinant Tissue Plasminogen Activator (rt PA) and Mechanical Thrombectomy”. Drug Safety 6 (2019): 10.
  5. Aya Saeb., et al. “Using Fresh Frozen Plasma for Acute Airway Angioedema to Prevent Intubation in the Emergency Department: A Retrospective Cohort Study”. Hindawi Publishing Corporation (2016).
  6. C Vigneron., et al. “Angioedema associated with thrombolysis for ischemic stroke: analysis of a case-control study”. Journal of Internal Médecins (2019).
  7. Lang DM., et al. “International consensus on hereditary and acquired angioedema”. Annals of Allergy, Asthma and Immunology 109 (2012): 395-402.
  8. Senthil kumaran., et al. “Role of fresh-frozen plasma in angioedema progress and problems”. Journal of Emergency Medicine (2013): 292-293.
  9. T Caballero., et al. “Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part 2. Treatment, follow-up, and special situations”. Journal of Investigational Allergology and Clinical Immunology (2011): 422-441.
  10. Wilkerson RG. “Angioedema in the emergency department: an evidence-based review”. Emergency Medicine Practice 11 (2012): 1-21.
Citation: Narjes M., et al. “Bradykinin-Mediated Angioedema Related to Alteplase Successfully Treated by Frozen Fresh Plasma: First Case Report with Literature Review”. EC Neurology 13.7 (2021): 51-54.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


December Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the December issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 20, 2021.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk