Review Article
Volume 13 Issue 5 - 2021
Brain Microenvironmental Changes Associated with the COVID-19 May Act as a New Medical Hypothesis to Explain the pathogenicity of the COVID-19
Ahed J Alkhatib1,2*
11Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan
2Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, International Mariinskaya Academy, Jordan
*Corresponding Author: Ahed J Alkhatib, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology and Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, International Mariinskaya Academy, Jordan.
Received: April 04, 2021; Published: April 22, 2021


COVID-19 has become the most important medical news at global level. Although it is well -known that its impacts are more likely to occur in the respiratory system, the appearance of neurological symptoms in patients with COVID-19 raised important questions as if the virus infected human brain or if it is a matter of overstimulation of the infection. Although studies showed controversial findings, autopsy findings of people with COVID-19 have confirmed the existence of the virus in the brain tissue. We have postulated our hypothesis in which the pathogenicity of the virus implied that some microenvironmental and cross-talks exist to facilitate the pathology of COVID-19. Interactions with receptors in the astrocytes such as ACE2, NRP1, and BSG to facilitate the invasion of the virus have been reported. Other biochemical changes in metabolic pathways such as Glycolysis/Gluconeogenesis, and carbon oxidation have been reported in relation with pathogenicity of the COVID-19. Taken together, COVID-19 infects brain cells and induce microenvironmental changes by potential cross-talks with various components to facilitate its existence and pathogenicity.

Keywords: COVID-19; Medical Hypothesis; Pathogenicity; Glycolysis; Gluconeogenesis


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Citation: Ahed J Alkhatib. “Brain Microenvironmental Changes Associated with the COVID-19 May Act as a New Medical Hypothesis to Explain the pathogenicity of the COVID-19”. EC Neurology 13.5 (2021): 78-81.

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