Mini Review
Volume 13 Issue 6 - 2021
Parkinson’s Disease, the Rationale to Start Treatment Early, Start Low and Go Slow
Roy G Beran1,2,3*
1Conjoint Professor, South Western Clinical School, University of New South Wales, Sydney, NSW, Australia
2Professor, Medical School, Griffith University, Broadbeach, Qld, Australia
2Professor, Chair, Medical Law, Sechenov, Moscow First State University, Moscow, Russia
*Corresponding Author: Roy G Beran, Conjoint Professor, South Western Clinical School, University of New South Wales, Sydney, PO Box 598, Northbridge, NSW 1560, Australia.
Received: April 11, 2021; Published: May 27, 2021


Introduction: Parkinson’s disease (PD) is the second most common neurodegenerative disease. Idiopathic PD may be more prevalent with the suggestion that PD is part of the natural progression of aging.

Background Information: The diagnosis of PD is a clinical diagnosis with no absolutely reliable, antemortem, objective test for diagnosis which remains reliant on the cardinal features of bradykinesia, rigidity and resting tremor with a basic requirement of at least two out of these three features. The neurones involved in PD are the same as those involved during aging. Progression of PD is more dependent upon advancing age, rather than duration, with the hall mark features of PD being significantly increased with age.

Discussion: The interchange of PD with aging led to an alternative approach to the management reliant on early initiation of L dopa, once PD is clinically evident, starting very low and going very slow. This was subjected to an audit confirming efficacy when compared to current regimen.

Conclusion: There is justification for the hypothesis that idiopathic PD represents aging, rather than a true pathophysiological disease, and very early introduction of dopamine replacement and supplementation, starting low and going slow is a viable alternative.

Keywords: Parkinson’s Disease; Treatment, Pathophysiology, Neuro Degeneration, Aging


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Citation: Roy G Beran. “Parkinson’s Disease, the Rationale to Start Treatment Early, Start Low and Go Slow”. EC Neurology 13.6 (2021): 65-68.

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