Review Article
Volume 13 Issue 5 - 2021
New Variant of Corona Virus and its Crosstalk with Alzheimer’s Disease
Rishika Dhapola and Dibbanti HariKrishna Reddy*
Department of Pharmacology, Central University of Punjab, Bathinda, India
*Corresponding Author: Dibbanti HariKrishna Reddy, Assistant Professor, Department of Pharmacology, Central University of Punjab, Bathinda, India.
Received: March 22, 2021; Published: April 21, 2021




Abstract

Being a pandemic disease as declared by WHO, Corona virus disease caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-Cov-2) has become the major reason for death of people worldwide. This article provides a glimpse of the symptoms caused by the invasion of virus, structure of the virus and conveyance of the virus from infected person to healthy individual and some of the new strains which have been detected recently. Alzheimer’s disease causing dementia is another co-morbidity causing death of covid-19 patients, correlation between these two fatal diseases is grabbing attention of scientists in various parts of the world. This study shows the interaction of Covid-19 with Angiotensin converting enzyme 2 (ACE2) receptors lead to stimulation of neuroinflammation which paves the way towards the progression of Alzheimer’s disease. As Apolipoprotein E4 (ApoE4) gene possessing people are susceptible for Alzheimer’s disease pathologies, similar susceptibility has been found in SARS-Cov-2 invasion. Cytokine storm stimulated by SARS-Cov-2 virus is also involved in the exacerbation of immune responses in CNS by over activating the brain cells including astrocytes and microglia. These events lead to neuroinflammation and eventually progress the Alzheimer’s disease condition. As the disease is posing serious burden on global health, getting an insight into the disease to develop new treatment and prevention strategies are of utmost importance for the scientists all over the world.

 

Keywords: Covid-19; Alzheimer’s Disease; New Strains; B117; B1351

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Citation: Rishika Dhapola and Dibbanti HariKrishna Reddy. “New Variant of Corona Virus and its Crosstalk with Alzheimer’s Disease”. EC Neurology 13.5 (2021): 57-64.

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