Research Article
Volume 12 Issue 12 - 2020
Self-Reported Outcomes of Mexican Multiple Sclerosis Outpatients and their Impact on Quality of Life Status
Brenda Bertado-Cortés1* and Luis Enrique Molina-Carrión2
1Centro Médico Nacional “Siglo XXI” Instituto Mexicano del Seguro Social, Mexico City, Mexico
2Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Mexico City, Mexico
*Corresponding Author: Brenda Bertado-Cortés, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Received: October 28, 2020; Published: November 28, 2020




Abstract

Introduction: Multiple sclerosis is a frequent cause of disability that produces physical and psychological disorders in young people. This demyelinating disease significantly impacts on quality of life of patients attenuating their daily life activities. There are few reports focused on correlating physical and psychological comorbidities and pharmacotherapy with quality of life status in the Mexican population. We aimed to describe major clinical, physical, and psychosocial characteristics of MS, which attenuate the quality of life of outpatients from two Mexican third-level medical centers.

Materials and Methods: An observational, cross-sectional, retrospective study was performed by applying a self-reported QoL assessment survey (FAMS) in Mexican MS outpatients. A correlation analysis for determining the association between different physical, emotional, clinical, and treatment aspects of MS and quality of life was made.

Results: Ninety-six questionnaires from both medical centers were collected. Of the total population, 64% were female patients with a mean age of 38 (±12) years old. The median time of diagnosis (years) and the first disease-modifying therapy onset was 7.5 (±5.0) years. Dimensions with highest impact on quality of life were emotional well-being (rp = -0.829, p < 0.0001), fatigue (rp = -0.807, p < 0.0001), symptoms (rp = -0.774, p < 0.0001), and additional concerns (rp = -0.861, p < 0.0001), such as urinary symptoms, polyuria, depression, and drug-associated adverse events.

Conclusion: MS significantly affects the quality of life of sufferers. Depression, urinary symptoms, sleep disorder, and adverse events were the most attenuating conditions for these patients.

Keywords: Multiple Sclerosis; FAMS; Quality of Life; Cross-Sectional Studies; Health Surveys

References

    1. Van Munster CEP and Uitdehaag BMJ. “Outcome Measures in Clinical Trials for Multiple Sclerosis”. CNS Drugs 3 (2017): 217-236.
    2. Compston A and Coles A. “Multiple sclerosis”. Lancet9648 (2008): 1502-1517.
    3. Hernández-Ledesma AL., et al. “Coping strategies and quality of life in Mexican multiple sclerosis patients: Physical, psychological and social factors relationship”. Multiple Sclerosis Related Disorders 25 (2018): 122-127.
    4. Multiple Sclerosis International Federation. “Atlas of MS 2013: Mapping Multiple Sclerosis Around the World”. MS International Federation (2013).
    5. Bertado-Cortés B., et al. “Características clínicas y demográficas de los pacientes con esclerosis múltiple”. Revista Médica del Instituto Mexicano del Seguro Social (2016): 2-6.
    6. Corona T and Flores J. “Esclerosis múltiple (EM) en América Latina”. Revista Española de Esclerosis Múltiple 1 (2009): 5-8.
    7. Rodríguez-García A and Sotelo-Morales J. “Multiple sclerosis in Mexico”. Salud Pública de México5 (1970): 451-456.
    8. WHO Quality of Life Assessment Group. “¿Qué calidad de vida?/Grupo de la OMS sobre Ia calidad de vida”. Foro Mundial de la Salud4 (1996): 385-387.
    9. Matta APC., et al. “No evidence of disease activity in multiple sclerosis patients”. Expert Review of Neurotherapeutics 11 (2016): 1279-1284.
    10. Stangel M., et al. “Towards the implementation of ‘no evidence of disease activity’ in multiple sclerosis treatment: The multiple sclerosis decision model”. Therapeutic Advances in Neurological Disorders 1 (2015): 3-13.
    11. Baumstarck K., et al. “Measuring the Quality of Life in Patients with Multiple Sclerosis in Clinical Practice: A Necessary Challenge”. Multiple Sclerosis International 2013 (2013): 1-8.
    12. Fernández-Muñoz JJ., et al. “Is the association between health-related quality of life and fatigue mediated by depression in patients with multiple sclerosis? A Spanish cross-sectional study”. BMJ Open 1 (2018): 1-6.
    13. Induruwa I., et al. “Fatigue in multiple sclerosis - A brief review”. Journal of the Neurological Science 1-2 (2012): 9-15.
    14. Cores EV., et al. “Factores asociados con la situación laboral de pacientes con esclerosis múltiple”. Revista de Neurología 4 (2014): 175-183.
    15. Jennum P., et al. “The socioeconomic consequences of optic neuritis with and without multiple sclerosis: A controlled national study”. Acta Neurologica Scandinavica 4 (2013): 242-250.
    16. Marrie RA. “Comorbidity in multiple sclerosis: Implications for patient care”. Nature Reviews Neurology6 (2017): 375-382.
    17. Huijbregts SCJ., et al. “Cognitive impairment and decline in different MS subtypes”. Journal of the Neulogical Science 1-2 (2006): 187-194.
    18. Arnett P., et al. “Depression in multiple sclerosis: relationship to planning ability”. Journal of the International Neuropsychological Society6 (2001): 665-674.
    19. Arnett PA., et al. “Depression in multiple sclerosis: Relationship to working memory capacity”. Neuropsychology 4 (1999): 546-556.
    20. Veauthier C. “Sleep Disorders in Multiple Sclerosis. Review”. Current Neurology and Neuroscience Reports 5 (2015): 1-10.
    21. Yorke AM and Cohen ET. “Functional Assessment of Multiple Sclerosis”. Journal of Physiotherapy4 (2015): 226.
    22. Janik MK., et al. “Autoimmune hepatitis exerts a profound, negative effect on health-related quality of life: A prospective, single-centre study”. Liver International1 (2019): 215-221.
    23. Takahashi A., et al. “Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey”. PLoS One10 (2018): e0204772.
    24. Battista MD., et al. “One year in review 2018: Systemic lupus erythematosus”. Clinical and Experimental Rheumatology 5 (2018): 763-777.
    25. Multiple Sclerosis International Federation. “Seven principles to improve quality of life with MS”. MS International Federation (2017).
    26. Krokavcova M., et al. “Perceived health status as measured by the SF-36 in patients with multiple sclerosis: A review”. Scandinavian Journal of Caring Sciences3 (2009): 529-538.
    27. Obiwuru O., et al. “Perceptions of multiple sclerosis in Hispanic Americans: Need for targeted messaging”. International Journal of MS Care3 (2017): 131-139.
    28. Kotterba S., et al. “Sleep quality, daytime sleepiness, fatigue, and quality of life in patients with multiple sclerosis treated with interferon beta-1b: Results from a prospective observational cohort study”. BMC Neurology 1 (2018): 1-10.
    29. Krbot Skorić M., et al. “Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue”. Clinical Autonomic Research 29 (2018 ): 321-328.
    30. Bartnik P., et al. “Sexual dysfunction in female patients with relapsing-remitting multiple sclerosis”. Brain and Behavior6 (2017): e00699.
    31. Coyle PK., et al. “Patient-reported outcomes in relapsing forms of MS: Real-world, global treatment experience with teriflunomide from the Teri-PRO study”. Multiple Sclerosis and Related Disorders 17 (2017): 107-115.
Citation: Brenda Bertado-Cortés and Luis Enrique Molina-Carrión. “Self-Reported Outcomes of Mexican Multiple Sclerosis Outpatients and their Impact on Quality of Life Status”. EC Neurology 12.12 (2020): 83-93.

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