Research Article
Volume 12 Issue 12 - 2020
Self-Reported Outcomes of Mexican Multiple Sclerosis Outpatients and their Impact on Quality of Life Status
Brenda Bertado-Cortés1* and Luis Enrique Molina-Carrión2
1Centro Médico Nacional “Siglo XXI” Instituto Mexicano del Seguro Social, Mexico City, Mexico
2Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Mexico City, Mexico
*Corresponding Author: Brenda Bertado-Cortés, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Received: October 28, 2020; Published: November 28, 2020


Introduction: Multiple sclerosis is a frequent cause of disability that produces physical and psychological disorders in young people. This demyelinating disease significantly impacts on quality of life of patients attenuating their daily life activities. There are few reports focused on correlating physical and psychological comorbidities and pharmacotherapy with quality of life status in the Mexican population. We aimed to describe major clinical, physical, and psychosocial characteristics of MS, which attenuate the quality of life of outpatients from two Mexican third-level medical centers.

Materials and Methods: An observational, cross-sectional, retrospective study was performed by applying a self-reported QoL assessment survey (FAMS) in Mexican MS outpatients. A correlation analysis for determining the association between different physical, emotional, clinical, and treatment aspects of MS and quality of life was made.

Results: Ninety-six questionnaires from both medical centers were collected. Of the total population, 64% were female patients with a mean age of 38 (±12) years old. The median time of diagnosis (years) and the first disease-modifying therapy onset was 7.5 (±5.0) years. Dimensions with highest impact on quality of life were emotional well-being (rp = -0.829, p < 0.0001), fatigue (rp = -0.807, p < 0.0001), symptoms (rp = -0.774, p < 0.0001), and additional concerns (rp = -0.861, p < 0.0001), such as urinary symptoms, polyuria, depression, and drug-associated adverse events.

Conclusion: MS significantly affects the quality of life of sufferers. Depression, urinary symptoms, sleep disorder, and adverse events were the most attenuating conditions for these patients.

Keywords: Multiple Sclerosis; FAMS; Quality of Life; Cross-Sectional Studies; Health Surveys


    1. Van Munster CEP and Uitdehaag BMJ. “Outcome Measures in Clinical Trials for Multiple Sclerosis”. CNS Drugs 3 (2017): 217-236.
    2. Compston A and Coles A. “Multiple sclerosis”. Lancet9648 (2008): 1502-1517.
    3. Hernández-Ledesma AL., et al. “Coping strategies and quality of life in Mexican multiple sclerosis patients: Physical, psychological and social factors relationship”. Multiple Sclerosis Related Disorders 25 (2018): 122-127.
    4. Multiple Sclerosis International Federation. “Atlas of MS 2013: Mapping Multiple Sclerosis Around the World”. MS International Federation (2013).
    5. Bertado-Cortés B., et al. “Características clínicas y demográficas de los pacientes con esclerosis múltiple”. Revista Médica del Instituto Mexicano del Seguro Social (2016): 2-6.
    6. Corona T and Flores J. “Esclerosis múltiple (EM) en América Latina”. Revista Española de Esclerosis Múltiple 1 (2009): 5-8.
    7. Rodríguez-García A and Sotelo-Morales J. “Multiple sclerosis in Mexico”. Salud Pública de México5 (1970): 451-456.
    8. WHO Quality of Life Assessment Group. “¿Qué calidad de vida?/Grupo de la OMS sobre Ia calidad de vida”. Foro Mundial de la Salud4 (1996): 385-387.
    9. Matta APC., et al. “No evidence of disease activity in multiple sclerosis patients”. Expert Review of Neurotherapeutics 11 (2016): 1279-1284.
    10. Stangel M., et al. “Towards the implementation of ‘no evidence of disease activity’ in multiple sclerosis treatment: The multiple sclerosis decision model”. Therapeutic Advances in Neurological Disorders 1 (2015): 3-13.
    11. Baumstarck K., et al. “Measuring the Quality of Life in Patients with Multiple Sclerosis in Clinical Practice: A Necessary Challenge”. Multiple Sclerosis International 2013 (2013): 1-8.
    12. Fernández-Muñoz JJ., et al. “Is the association between health-related quality of life and fatigue mediated by depression in patients with multiple sclerosis? A Spanish cross-sectional study”. BMJ Open 1 (2018): 1-6.
    13. Induruwa I., et al. “Fatigue in multiple sclerosis - A brief review”. Journal of the Neurological Science 1-2 (2012): 9-15.
    14. Cores EV., et al. “Factores asociados con la situación laboral de pacientes con esclerosis múltiple”. Revista de Neurología 4 (2014): 175-183.
    15. Jennum P., et al. “The socioeconomic consequences of optic neuritis with and without multiple sclerosis: A controlled national study”. Acta Neurologica Scandinavica 4 (2013): 242-250.
    16. Marrie RA. “Comorbidity in multiple sclerosis: Implications for patient care”. Nature Reviews Neurology6 (2017): 375-382.
    17. Huijbregts SCJ., et al. “Cognitive impairment and decline in different MS subtypes”. Journal of the Neulogical Science 1-2 (2006): 187-194.
    18. Arnett P., et al. “Depression in multiple sclerosis: relationship to planning ability”. Journal of the International Neuropsychological Society6 (2001): 665-674.
    19. Arnett PA., et al. “Depression in multiple sclerosis: Relationship to working memory capacity”. Neuropsychology 4 (1999): 546-556.
    20. Veauthier C. “Sleep Disorders in Multiple Sclerosis. Review”. Current Neurology and Neuroscience Reports 5 (2015): 1-10.
    21. Yorke AM and Cohen ET. “Functional Assessment of Multiple Sclerosis”. Journal of Physiotherapy4 (2015): 226.
    22. Janik MK., et al. “Autoimmune hepatitis exerts a profound, negative effect on health-related quality of life: A prospective, single-centre study”. Liver International1 (2019): 215-221.
    23. Takahashi A., et al. “Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey”. PLoS One10 (2018): e0204772.
    24. Battista MD., et al. “One year in review 2018: Systemic lupus erythematosus”. Clinical and Experimental Rheumatology 5 (2018): 763-777.
    25. Multiple Sclerosis International Federation. “Seven principles to improve quality of life with MS”. MS International Federation (2017).
    26. Krokavcova M., et al. “Perceived health status as measured by the SF-36 in patients with multiple sclerosis: A review”. Scandinavian Journal of Caring Sciences3 (2009): 529-538.
    27. Obiwuru O., et al. “Perceptions of multiple sclerosis in Hispanic Americans: Need for targeted messaging”. International Journal of MS Care3 (2017): 131-139.
    28. Kotterba S., et al. “Sleep quality, daytime sleepiness, fatigue, and quality of life in patients with multiple sclerosis treated with interferon beta-1b: Results from a prospective observational cohort study”. BMC Neurology 1 (2018): 1-10.
    29. Krbot Skorić M., et al. “Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue”. Clinical Autonomic Research 29 (2018 ): 321-328.
    30. Bartnik P., et al. “Sexual dysfunction in female patients with relapsing-remitting multiple sclerosis”. Brain and Behavior6 (2017): e00699.
    31. Coyle PK., et al. “Patient-reported outcomes in relapsing forms of MS: Real-world, global treatment experience with teriflunomide from the Teri-PRO study”. Multiple Sclerosis and Related Disorders 17 (2017): 107-115.
Citation: Brenda Bertado-Cortés and Luis Enrique Molina-Carrión. “Self-Reported Outcomes of Mexican Multiple Sclerosis Outpatients and their Impact on Quality of Life Status”. EC Neurology 12.12 (2020): 83-93.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

December Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the December issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 17, 2021.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to