Case Study
Volume 12 Issue 12 - 2020
New Medicine: New Therapeutic Approach for Cerebral Palsy: The Use of Tadalafil 5 Mg Daily, Magnesium, and Zinc as a New Medical Hypothesis
Ahed J Alkhatib1,2*
1Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan
2International Mariinskaya Academy, Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, Jordan
*Corresponding Author: Ahed J Alkhatib, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology and International Mariinskaya Academy, Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, Jordan.
Received: October 07, 2020; Published: November 26, 2020




Abstract

This study represents a study case of a male, 13 years old, diagnosed with cerebral palsy. In general, the child suffered from growth failure as compared with his peers, he also suffered from movement inability, a wheel chair is required for movement. Eating disturbances were reported by his mother. Sleeping disturbances were also reported by the mother. The child was seen in many clinics in the public, military and private sectors. The final diagnosis with cerebral palsy was confirmed. Conservative convenient treatments were prescribed. No improvements in the total outcomes were observed. As the child grows up, his needs increased in terms of care, and other social issues. The mother asked for untraditional advice. Based on recent reports, tadalafil 5 mg daily upregulates the expression of heat shock protein 70 in the nervous system, which improves the depression status among patients with erectile dysfunction. From previous experience, we are aware of the importance of upregulation of HSP70 in nervous system. We also used the treatment of magnesium, zinc, and chromium for epilepsy. Taken together, we based our therapeutic hypothesis: “upregulation of HSP70 in nervous system and improvement of micro-environmental chemistry of nervous tissue through providing magnesium, zinc, and chromium, is a new therapeutic approach for cerebral palsy”. This approach has been so far applied for two months with the following results according to reports of child’s mother: good movement with self-dependence, no more food disturbances, and no sleep disturbances. Taken together, the prescribed therapeutic approach was successfully applied.

Keywords: Cerebral Palsy; Tadalafil; Magnesium; Zinc; Chromium; Hypothesis

References

  1. H Kerr Graham., et al. “Cerebral palsy”. Nature Reviews 2 (2016): 15082.
  2. Brooks J C., et al. “Recent trends in cerebral palsy survival. Part I: period and cohort effects”. Developmental Medicine and Child Neurology 56 (2014a): 1059-1064.
  3. Brooks JC. et al. “Recent trends in cerebral palsy survival. Part II: individual survival prognosis”. Developmental Medicine and Child Neurology 56 (2014b) 1065-1071.
  4. Hsiao YJ. “Parental stress in families of children with dis-abilities”. Intervention in School and Clinic 53 (2018): 201-205.
  5. McCoy SW., et al. “Physical, occupational, and speech therapy for children with cerebral palsy”. Developmental Medicine and Child Neurology 62 (2019): 140-146.
  6. Chia-Ying Chung., et al. “Pharmacotherapy of Spasticity in Children with Cerebral Palsy”. Journal of the Formosan Medical Association 4 (2011): 215-222.
  7. Tilton AH. “Management of spasticity in children with cerebral palsy”. Seminar on Pediatric Neurology 11 (2004): 58-65.
  8. Coward RM and Carson CC. “Tadalafil in the treatment of erectile dysfunction”. Therapeutics and Clinical Risk Management 6 (2008): 1315-1330.
  9. Verit A., et al. “Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study”. International Journal of Impotence Research 2 (2020): 115-119.
  10. Chen Y., et al. “The effects of long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via a local antioxidative mechanism”. Asian Journal of Andrology4 (2012): 616-620.
  11. Koka S., et al. “Phosphodiesterase 5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice”. Free Radical Biology and Medicine 60 (2013): 80-88.
  12. Al Amin MM., et al. “Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice”. European Journal of Pharmacology 745 (2014): 84-90.
  13. Choi J B., et al. “The Effect of Daily Low Dose Tadalafil on Cerebral Perfusion and Cognition in Patients with Erectile Dysfunction and Mild Cognitive Impairment”. Clinical Psychopharmacology and Neuroscience: The Official Scientific Journal of the Korean College of Neuropsychopharmacology3 (2019): 432-437.
  14. Carolina García Barroso., et al. “Tadalafil crosses the blood brain barrier and reverses cognitive dysfunction in a mouse model of AD”. Neuropharmacology 64 (2013): 114-123.
  15. Al-khatib A. “Co-expression of iNOS and hsp70 in diabetes type 1 makes a rational hypothesis to explain the diabetic neuropathy”. European Scientific Journal ESJ3 (2013).
  16. Ahed J Alkhatib. “New Insights to Diabetes: Is Diabetes a Metabolic Disorder or a Neurological Disease?” International Journal of Diabetes and Metabolic Disorders1 (2019): 1-2.
  17. Ahed J Alkhatib. “Bio-Organic Approach of Epilepsy Treatment: New Horizon for Future Neurological Treatment”. Clinical Neurology1 (2020a): 1003.
  18. Ahed J Alkhatib. “Prediabetes can be Reversed Using Low Dose Tadalafil: Non- Classical Treatment of Diabetes as A New Medical Hypothesis”. Archives of Diabetes and Obesity5 (2020b).
  19. Jin Bong Choi., et al. “The Effect of Daily Low Dose Tadalafil on Cerebral Perfusion and Cognition in Patients with Erectile Dysfunction and Mild Cognitive Impairment”. Clinical Psychopharmacology and Neuroscience3 (2019): 432-437.
  20. Alkhatib AJ. “The Progression of a Disease Depends on Downregulation of Heat Shock Protein 70 (HSP70) And Upregulation of Inducible Nitric Oxide Synthase (iNOS): A New Medical Hypothesis”. Biomed Discoveries (2018).
Citation: Ahed J Alkhatib. “New Medicine: New Therapeutic Approach for Cerebral Palsy: The Use of Tadalafil 5 Mg Daily, Magnesium, and Zinc as a New Medical Hypothesis”. EC Neurology 12.12 (2020): 36-39.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


December Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the December issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 17, 2021.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk