Research Article
Volume 12 Issue 10 - 2020
Assessment of Serum Electrolyte Disorders and Associated Factors among Patients with Neurologic Diseases Admitted to Jimma Medical Center, South West Ethiopia
Lemlemu Maru1, Chala Kenenisa Edae2*, Samuel Abebe1, Wondu Reta1, Endriyas Kelta Wabalo2, Almaz Bedane1, Moyeta Bariso1, Amare Abera1, Gadisa Bedada3 and Belay Zawdie Wondimu2
1Department of Biomedical Sciences, Physiology Unit, Institute of Health, Jimma University, Ethiopia
2Department of Biomedical Sciences, Medical Biochemistry Unit, Institute of Health, Jimma University, Ethiopia
3Department of Nursing Institute of Health, Jimma University, Ethiopia
*Corresponding Author: Chala Kenenisa Edae, Department of Biomedical Sciences, Medical Biochemistry Unit, Institute of Health, Jimma University, Ethiopia.
Received: October 19, 2020; Published: November 26, 2020


Background: Electrolyte disorder is the most frequent systemic complication in patients with neurologic diseases. Disorders of sodium and potassium concentration are the most common electrolyte abnormalities and may contribute to mortality unless corrected urgently.

Objective: To assess the magnitude of serum electrolyte (sodium, potassium, calcium, and chloride) disorders and associated factors among adult patients with neurologic diseases admitted to Jimma Medical Center.

Methods: Institutional based cross-sectional study was conducted among selected 119 adult neurologic patients by using stratified sampling technique. Blood was drawn from patients with neurologic diseases, centrifuged and level of serum electrolyte (Na, K, Cl and Ca) was determined. Data was fed into epidata 64 and exported to SPSS version 20. Binary logistic regression was used to identify the associated factors to electrolyte disorder. Data was expressed in percentage, mean, ± SD and P-value ≤ 0.05 considered as a statistically significant. Data was presented with text, tables.

Results: The prevalence of at least one electrolyte disorder was 71.4%. The prevalence of hyponatremia, hypokalemia, hypochloremia, hyperchloremia, hypocalcemia, hypernatremia and hyperkalemia were seen in 37%, 35.3%, 21.8%, 19.3%, 16%,14.3% and 1.7%, of patients), respectively. Hypercalcemia was not found. Occupation, comatose state, taking intravenous fluids, taking thiazides, both antibiotics and analgesics, history of chronic diseases like hypertension and diabetes were factors associated with serum electrolyte disorders.

Conclusion and Recommendation: Hyponatremia and hypokalemia were common electrolyte disorders. Therefore, early screening or measurement of serum electrolyte should be done for high risk groups.

Keywords: Prevalence; Electrolyte Disorders; Associated Factors; Neurologic Diseases; JMC


  1. Castilla L., et al. “Electrolytes Disturbances and Seizures”. International League Against Epilepsy 12 (2006): 1990-1998.
  2. Borah M., et al. “Derangement of Serum Electrolyte Status in Cerebrovascular Accident - A Hospital Based Observational Study in Shillong, Meghalaya”. International Journal of Health Sciences and Research 6 (2016): 84-90.
  3. Biller J and Ferro M. “Neurologic complications of electrolyte disturbances and acid - base balance”. Neurologic Aspects of Systemic Disease. Elsevier Ltd 119 (2014): 1-19.
  4. Electrolyte Disturbance in hemorrghic and non hemorrghic Stroke Patients in AL-Diwaniyh Teaching Hospital 2.
  5. Chin N and Jerome H. “Global burden of neurologic diseases”. American Academy of Neurology 83 (2014): 349-351.
  6. Gupta S., et al. “Electrolytes Imbalance in Traumatic Brain Injury Patients”. International Journal of Medical Sciences 1 (2013): 2349-3208.
  7. Kim DK and Joo KW. “Hyponatremia in Patients with Neurologic Disorders”. Electrolytes Blood Press 7 (2009): 51-57.
  8. Waseem S., et al. “Hyponatremia in Patients with Bacterial Meningitis and its Association with in-Hospital Mortality”. Pakistan Journal of Medical and Health Sciences 4 (2016): 1363-1366.
  9. Kraft MD., et al. “Treatment of electrolyte disorders in adult patients in the intensive care unit”. American Journal of Health-System Pharmacy 15. 62 (2005): 1663-1682.
  10. Lath R. “Hyponatremia in neurological diseases in ICU”. Indian Journal of Critical Care Medicine 1 (2005): 47-51.
  11. Adeleye M and Amos O. “Clinical Epidemiology of Head Injury from Road-Traffic Trauma in a Developing Country in the Current Era”. Frontiers in Neurology 8 (2017): 8-10.
  12. Liamis G., et al. “Electrolyte Disorders in Community Subjects : Prevalence and Risk Factors”. AJM3 (2013): 256-263.
  13. Mousavi SJ. “Comparison of the Serum Electrolyte Levels among Patients Died and Survived in the Intensive Care Unit”. National Research Institute of Tuberculosis and Lung Diseases4 (2012) 36-42. 11(2012): 36-42.
  14. Biniyam A., et al. “Severe hypokalemia mimicking guillain-barré syndrome in 42-years-old Ethiopian patient-case report”. AJNS - African Journal of Neurological Sciences (2017): 1-3.
  15. Tisdall M., et al. “Disturbances of sodium in critically ill adult neurologic patients: A clinical review”. Journal of Neurosurgical Anesthesiology 18 (2006): 57-63.
  16. Zahra Chitsazian BZ and MM. “Prevalence of Hyponatremia in Intensive Care Unit Patients With Brain Injury in Kashan Shahid-Beheshti Hospital” (2013): 91-94.
  17. Pradhan B., et al. “Clinical profiles, electrolytes status in acute strokes and their outcome”. International Journal of Advances in Medicine 3 (2018): 492-497.
  18. Panda M., et al. “Altered Serum Electrolyte Status in Acute Stroke Patients in Western Odisha, A Predictor of Syndrome of Inappropriate ADH (SIADH) or Cerebral Salt Wasting Syndrome (CSWS)”. Journal of Clinical and Diagnostic Research 1 (2019): 10-13.
  19. Jha AK., et al. “Serum Electrolyte Imbalances in Head Injury Patients: An Institutional Analysis”. International Journal of Scientific Research 12 (2017): 2016-2018.
  20. Oo Ogunleye., et al. “Electrolytes profile of patients with traumatic brain injury; prospective observational study in sokoto, Nigeria”. International Journal of Innovative Research and Advanced Studies 4 (2018): 5-7.
  21. Kalyan M., et al. “Electrolyte Imbalance In Acute Stroke”. National Journal of Integrated Research in Medicine 4 (2017): 23-26.
  22. Vedantam A., et al. “Morbidity and mortality associated with hypernatremia in patients with severe traumatic brain injury”. Neurosurgical Focus 43 (2017): 1-5.
  23. Suman S., et al. “Evaluation of Serum Electrolytes in Traumatic Brain Injury Patients: Prospective Randomized Observational Study”. Journal of Anesthesia and Critical Care: Open Access 3 (2016): 1-6.
  24. Jaffri A., et al. “Neuroinfectious Diseases Frequency of Hyponatremia in Central Nervous System Infections”. Journal of Neuroinfectious Diseases 3 (2015): 1-6.
  25. Chung M., et al. “Hyponatremia and increased risk of dementia : A population-based retrospective cohort study”. PLoS One 10 (2017): 1-11.
  26. Mawed S Al., et al. “Low serum sodium levels at hospital admission : Outcomes among 2 . 3 million hospitalized patients”. PLOSONE3 (2018): 1-17.
  27. Elisaf M., et al. “Alcoholism and Drug Dependence Metabolic Abnormalities in Alcoholic Patients: Focus on Acid Base and Electrolyte Disorders”. Journal of Alcoholism and Drug Dependence 1 (2015): 1-6.
  28. Bei H., et al. “Prognostic role of hypochloremia in acute ischemic stroke patients”. Acta Neurologica Scandinavica 136 (2017): 672-679.
  29. Bandyopadhyay M., et al. “Study of Electrolyte Abnormality in Acute Stroke”. Annals of International Medical and Dental Research 5 (2017): 4-9.
  30. Metwally H and Seddeek MI. “Acute stroke and serum sodium level among a sample of Egyptian patients”. Natural Sciences 12 (2016): 10-15.
  31. Pin-on P., et al. “Serum electrolyte imbalance and prognostic factors of postoperative death in adult traumatic brain injury patients”. Medicine45 (2018): 10-12.
  32. Kembuan MAHN and Sekeon SAS. “Electrolyte disturbances among acute stroke patients in Manado, Indonesia”. Global Journal of Medicine and Public Health 1 (2014): 2277-9604.
  33. Hassan HM., et al. “Risk factors, electrolyte disturbances and lipid profiles in Sudanese patients with stroke”. Journal of Public Health and Epidemiology 10 (2015): 324-330.
  34. M Rahman N and Kohler AB. “Water and Electrolyte Management in Neurological Disease”. Textb Neurointensive Care, Springer-Verlag London 5 (2013): 3-24.
  35. Faisal M., et al. “Serum electrolyte derangements in patients with traumatic brain injury”. Journal of Ayub Medical College 25 (2013): 162-164.
  36. França DA and Oliveira RL. “Serum sodium disorders in patients with traumatic brain injury”. Therapeutics and Clinical Risk Management 7 (2011): 345-349.
  37. Karmacharya B., et al. “Dyselectrolytemia and Leucocytosis in Traumatic Brain Injury Patients”. American Journal of Public Health Research 5 (2015): 99-101.
  38. Bhoola RBR van DD. “Hyponatremic Natriuretic Syndrome in Tuberculous Meningitis: The Probable Role of Atrial Natriuretic Peptide”. Oxford University press (1994): 982-988.
  39. Quian Q. “Dietary Influence on Body Fluid Acid-Base and Volume Balance The Deleterious “Norm” Furthers and Cloaks Subclinical Pathophysiology”. Nutrients (2018): 778.
  40. Wabe NT Chemistry. “Pharmacology, and Toxicology of Khat (Catha Edulis Forsk): A Review”. Addict Heal3 (2011): 137-149.
  41. Arampatzis S., et al. “Impact of diuretic therapy-associated electrolyte disorders present on admission to the emergency department: a cross-sectional analysis”. BMC Medicine 11 (2013): 2-6.
  42. Jiang JY Ong., et al. “Association of antihypertensive monotherapy with serum sodium and potassium levels in Chinese patients”. American Journal of Hypertension 3 (2009): 243-249.
  43. Anthony J. “And Noah Wouk. Potassium Disorders_ Hypokalemia and Hyperkalemia”. American Family Physician (2015): 487-495.
  44. Mahesar SA., et al. “Evaluation of Hyponatremia in Ischemic Stroke Patients in a Tertiary Care Hospital of Karachi, Pakistan”. Cureus1 (2019): 1-7.
  45. George Liamis., et al. “Diabetes mellitus and electrolyte disorders” (2014): 488-496.
  46. Nnadi Henrrietta Ogadimma., et al. “Assessment of Electrolyte Levels in Hypertensive Patients in University of Port Harcourt Teaching Hospital, Port Harcourt”. American Journal of PharmTech Research 1 (2016): 1-6.
Citation: Chala Kenenisa Edae., et al. ““Assessment of Serum Electrolyte Disorders and Associated Factors among Patients with Neurologic Diseases Admitted to Jimma Medical Center, South West Ethiopia”. EC Neurology 12.12 (2020): 03-19.

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