Research Article
Volume 12 Issue 11 - 2020
The Effect of Cretan High Phenolic Olive Oil on Fecal Calprotectin Levels in the Course of Multiple Sclerosis
Greta Wozniak1,2*, Marios Kyprou1 and Magda Tsolaki3
1Department of Psychology, University of Cyprus, Cyprus
2Medical School, University of Cyprus, Cyprus
31stDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Makedonia, Greece
*Corresponding Author: Greta Wozniak, MD., PhD, Medical School, University of Cyprus, Cyprus.
Received: October 08, 2020; Published: October 30, 2020




Abstract

Multiple sclerosis is a chronic immune-related inflammatory disease of the central nervous system that results in demyelination and lesions in the brain. Even though there is a massive research for the whole profile and treatment of the disease, to date, the etiopathology of multiple sclerosis is still unclear and there is no fully successful therapy. The urgent need to find new therapies led us to the search for the potential therapeutic effects of high phenolic early harvest extra virgin olive oil (HP-EH-EVOO) that interacts with the gut-brain axis. Recent research dictates that olive oil polyphenols can confront oxidative damage and inflammation through gut microbiota alterations. Therefore, we conducted a pilot study with relapsing-remitting multiple sclerosis (RRMS) patients. Patients in the experimental group, consumed Eliama Daily Value Gold - HP-EH-EVOO for 4 months, while patients in the control group did not. We used fecal calprotectin measurements at baseline, 2 and 4 months during the oil consumption to observe the inflammation status of the patients and found a decreased inflammation in the experimental group [F(2,14) = 10.38, p = .002]. Our results gave us an insight on how we can take advantage of our diet to treat multiple sclerosis and other inflammatory diseases. Nonetheless, it is important for future studies with bigger samples to replicate our results and extend the investigation in order for HP-EH-EVOO to be a proper candidate for clinical and therapeutic use.

Keywords: Multiple Sclerosis; Calprotectin; Gut Microbiota; Extra Virgin Olive Oil; Polyphenols

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Citation: Greta Wozniak., et al. “The Effect of Cretan High Phenolic Olive Oil on Fecal Calprotectin Levels in the Course of Multiple Sclerosis”. EC Neurology 12.11 (2020): 65-79.

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