Review Article
Volume 12 Issue 11 - 2020
The Main Mechanisms of Brain Adaptation to Hypoxia
Vladimir Kuznecov1*, Solkin AA2 and Beljavkij NN2
1Department of Normal Physiology, Vitebsk State Medical University, Belarus
2Department of Neurology and Neurosurgery, Vitebsk State Medical University, Belarus
*Corresponding Author: Vladimir Kuznecov, Department of Normal Physiology, Vitebsk State Medical University, Belarus.
Received: August 27, 2020; Published: October 28, 2020


It shown that hypoxia causes a complex restructuring of the functioning of various body systems, which is aimed to maintain the delivery of the required amount of oxygen to tissues. Adaptation to hypoxia exerts a significant influence on the central nervous system, central hemodynamics, microcirculation in various organs, oxygen metabolism, free radical oxidation of lipids, the main systems detoxification enzymes and immunity. The mechanisms of adaptation to hypoxia in the brain are discussed. The improvement of cerebral circulation appears to be one of the most important protective effects of adaptation to hypoxia.

Keywords: Brain Adaptation; Hypoxia; Oxygen Metabolism


  1. Ignatenko G. “Modern possibilities of adaptive medicine”. Ukrainian Health 11 (2015).
  2. Agajanian N and Mirrahimov M. “Mountains and resistance of the organism”. Moscow: Science (1970).
  3. Nakata H et al. “Effects of acute hypoxia on human cognitive processing: a study using ERPs and SEPs”. Journal of Applied Physiology 5 (2017): 1246-1255.
  4. Plakhatnyuk V and Vavilov M. “Study of the human body's resistance to moderate hypoxia”. Use of gas hypoxic mixtures to optimize radiation therapy of malignant neoplasms: digest of articles. Obninsk (1984): 85-87.
  5. Agajanian N. “Organism and gas environment”. Moscow: Medicine (1972).
  6. Zakoschikov K and Katin S. “Hypoxytherapy - mountain air". Moscow: Paper gallery (2002).
  7. Schmidt-Nielsen K. “Animal Physiology: Adaptation and Environment”. Moscow: Mir (1982).
  8. Powell F and Garcia N. “Physiologic effects of intermittent normobaric hypoxia”. High Altitude Medicine and Biology2 (2000): 125-136.
  9. Rodrigues F., et al. “Intermittent hypobaric hypoxia stimulates erithropoesis and improves aerobic capacity”. Medicine and Science in Sports and Exercise2 (1999): 264-268.
  10. Belchenko L. “Adaptation of humans and animals to hypoxia of different origins”. Soros Education Journal7 (2001): 33-39.
  11. Meerson F. “Adaptation to periodic hypoxia in therapy and prevention”. Moscow: Science (1989).
  12. Berezovsky V et al. “Influence of modeling of mountain climate conditions on general and regional ventilation of the lungs”. Oxygen starvation and methods of hypoxia correction: digest of articles. Kiev: Naukova Dumka (1990): 68-75.
  13. Levashov M., et al. “State of the central link in the regulation of respiration in humans before and after exposure to intermittent normobaric hypoxia”. Fiziologicheskii Zhurnal3-4 (1996): 19-20.
  14. Meerson F., et al. “Differences in adaptive stabilization of structures in response to stress and hypoxia relate with the accumulation of hsp 70 isoforms”. Molecular and Cellular Biochemistry 111 (1992): 87-95.
  15. Wang Ch-T., et al. “Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats”. Journal of the Formosan Medical Association4 (2015): 328-338.
  16. Kitaev M., et al. “Effects of hypoxic hypoxia on development of atherosclerosis in rabbits”. Aviakosmicheskaia I Ekologicheskaia Meditsina5 (1999): 54-57.
  17. Prokofiev A., et al. “The influence of the course of adaptation to the action of periodic hypoxia on the lipid spectrum of blood serum in patients with myocardial infarction”. Hypoxia Medical Journal3-4 (2005): 55-58.
  18. Mikhalkina N and Zakreshev E. “Reaction of nonspecific immunity to the action of hypoxia”. Ecological physiology and adaptation problems: VII Russian symposium. Moscow (1994): 187.
  19. Alanova P., et al. “Myocardial ischemic tolerance in rats subjected to endurance exercise training during adaptation to chronic hypoxia”. Journal of Applied Physiology (1985) 122.6(2017): 1452-1461.
  20. Meerson F. “Adaptation medicine: mechanisms and protective effects of adaptation”. Moscow: Hypoxia Medical (1993).
  21. Sazontova T., et al. “Adaptation to periodic hypoxia and a diet with omega-3- polyunsaturated fatty acids increases the resistance of Ca2 + transport of the myocardial sarcoplasmic reticulum to free radical oxidation”. Bulletin of Experimental Biology and Medicine 120 (1995): 42-45.
  22. Wild-Bode C., et al. “Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42”. Journal of Biological Chemistry 272 (1997): I6085-I6088.
  23. Zavalishin I., et al. “Neurodegenerative diseases and aging”. Moscow: Elf IPR (2001).
  24. Meerson F. “Adaptation, stress and prophylaxis”. Berlin: Springer-Verlag (1984).
  25. Abraham I., et al. “Chronic corticosterone administration dose dependently modulates Abeta (1-42)- and NMDA induced neurodegenеration in rat magnocellular nucleus basalis”. Journal of Neuroendocrinology 12 (2000): 486-494.
  26. Manukhina E and Malyshev I. “Role of nitric oxide in protective effects of adaptation”. Adaptation biology and medicine/Eds. J. Moravec et al. New Delhi, Narosa Publishing House 3 (2002): 312-327.
  27. Cellermajer D. “Endothelial dysfunction: Does it matter? Is it reversible?”. Journal of the American College of Cardiology 30 (1997): 325-353.
  28. Gielen S., et al. “Exercise training in coronary artery disease and coronary vasomotion”. Circulation 103 (2001): E1-E6.
  29. Hampl V., et al. “Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium level in pulmonary artery endothelial cells”. European Respiratory Journal 8 (1995): 515-522.
  30. Muangritdech N., et al. “Hypoxic training improves blood pressure, nitric oxide and hypoxia-inducible factor-1 alpha in hypertensive patients”. European Journal of Applied Physiology8 (2020): 1815-1826.
  31. Colasanti M and Suzuki H. “The dual personality of NO”. Treatment Improvement Protocols 21 (2000): 249-252.
  32. Vanin A. “Dinitrozole complexes of iron and S-nitrosothiols - two possible forms of stabilization and transport of nitric oxide in biosystems”. Biochemistry 7 (1998): 924-938.
  33. Manukhina E., et al. “Deposition of nitric oxide in the cardiovascular system”. News of the Academy of Sciences 5 (2002): 585-596.
  34. Manukhina E., et al. “Changes in the density of the vascular network of the surface of the cerebral cortex in rats with experimental hypertension and adaptation to height”. Cardiology 10 (1982): 118-119.
  35. La Manna J., et al. “Brain adaptation to chronic hypobaric hypoxia in rats”. Journal of Applied Physiology 72 (1992): 2238- 2243.
  36. Patt S., et al. “Cerebral angiogenesis triggered by severe chronic hypoxia displays regional differences”. Journal of Cerebral Blood Flow and Metabolism 17 (1997): 801-806.
  37. Belenichev I., et al. “Rational neuroprotection”. Donetsk: Zaslavsky (2009): 21-31.
  38. Risau W. “Mechanisms of angiogenesis”. Nature 386 (1997): 671-674.
  39. Rybnikova E and Samoilov S. “Current insights into the molecular mechanisms of hypoxic pre- and postconditioning using hypobaric hypoxia”. Frontiers Neuroscience 9 (2015): 388.
  40. Karash Yu., et al. “Normobaric hypoxia in treatment, prevention and rehabilitation”. Moscow: Medicine (1988).
  41. Krapivin S., et al. “Neurophysiological mechanisms of adaptation to hypoxia of the central nervous system of animals with different resistance to lack of oxygen”. Ecological physiology and adaptation problems: VII Russian symposium. Moscow (1994): 128-129.
  42. Agajanian N., et al. “Normobaric hypoxic therapy ". Moscow: RUDN (1994).
  43. Shaov M et al. “Neurosynergetic mechanisms of oxygen homeostasis of the cerebral cortex in oxygen deficiency”. Advances in Modern Natural Science 3 (2004): 46.
  44. Kaur C., et al. “Plasma melatonin, pinealocyte morphology, and surface receptors/antigen expression on macrophages/ microglia in the pineal gland following a high altitude exposure”. Journal of Neuroscience Research 67 (2002): 533-543.
  45. Reiter R., et al. “Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington’s disease, Alzheimer’s disease and parkinsonism”. Annals of the New York Academy of Sciences 890 (1999): 471-485.
  46. Pappolla M., et al. “The heat shock/oxidative stress connection. Relevance to Alzheimer disease”. Molecular and Chemical Neuropathology 28 (1996): 21-34.
  47. Lebkova N and Chizhov A. “Reaction of hepatocytes of pregnant rats to intermittent normobaric hypoxia”. Interval hypoxic training (efficiency, mechanisms of action): digest of articles. Kiev (1992): 122-124.
  48. Lukyanova L., et al. “Regularities of the formation of the body's resistance under different modes of hypoxic preconditioning: the role of the hypoxic period and reoxygenation”. Bulletin of Experimental Biology and Medicine 4 (2009): 380-384.
  49. Samoilov M., et al. “The influence of preconditioning with moderate hypobaric hypoxia on the expression of Mn-superoxide dismutase in the hippocampus of rats”. Neurochemistry 3 (2007): 218-223.
  50. Scott A., et al. “Regulation of catecholamine release from the adrenal medulla is altered in deer mice (Peromyscus maniculatus) native to high altitudes”. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology3(2019): R407-R417.
  51. Glazachev O and Bobyleva O. “Dynamics of indices of autonomic reactivity and resistance to acute dosed hypoxia in the course of interval hypoxic training”. Human Physiology 2 (2007): 81-89.
Citation: Vladimir Kuznecov., et al. “The Main Mechanisms of Brain Adaptation to Hypoxia”. EC Neurology 12.11 (2020): 22-30.

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