Research Article
Volume 12 Issue 11 - 2020
Comparison of Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Lewy Body Dementia Brains with and without Cerebral Amyloid Angiopathy
Jacques De Reuck*, Florent Auger, Nicolas Durieux, Claude-Alain Maurage, Vincent Deramecourt, Charlotte Cordonnier, Florence Pasquier, Didier Leys and Regis Bordet>
Unitè 1171 “Degenerative and vascular cognitive disorders”, Université de Lille 2, Lille, France
*Corresponding Author: Jacques De Reuck, Unitè 1171 “Degenerative and vascular cognitive disorders”, Université de Lille 2, Lille, France.
Received: September 24, 2020; Published: October 28, 2020


Introduction and Purpose: Cerebral amyloid angiopathy (CAA) is frequently associated to Dementia with Lewy bodies (DLB). The impact of CAA on the degree of hippocampal atrophy (HA) and on the incidence of hippocampal cortical micro-infarcts (HCoMIs) and cortical micro-bleeds (HCoMBs) is unknown.

Materials and Methods: The examined post-mortem brains consisted 9 DLB-CAA cases and 20 DLB ones without CAA. The hippocampus was evaluated on the most representative coronal section with T2 and T2* 7.0-tesla MRI sequences. The average degree of HA was evaluated in both groups. The incidence of HCoMIs and HCoMBs was also compared as well as the frequency of CoMIs and CoMBs in the neocortex.

Results: No differences were observed in the degree of HA and in the incidence of HCoMIs and HCoMBs between the DLB-CAA and the DLB brains. The incidence of these cerebrovascular lesions in both groups is similar to that in the neocortex.

Discussion and Conclusion: CAA has no influence on the degree of HA and on the incidence of HCoMIs and HCoMBs in the hippocampus of DLB brains.

Keywords: Post-Mortem 7.0-Tesla Magnetic Resonance Imaging; Dementia with Lewy Bodies; Cerebral Amyloid Angiopathy; Hippocampal Atrophy; Cortical Micro-Infarcts; Cortical Micro-Bleeds


  1. Sanford AM. “Lewy body dementia”. Clinics in Geriatric Medicine 4 (2018): 603-615.
  2. Jellinger KA and Korczyn AD. “Are dementias with Lewy bodies and Parkinson’s disease dementia the same disease?” MMC Medical 1 (2018): 34.
  3. Geser F., et al. “How to diagnose dementia with Lewy bodies: state of the art”. Movement Disorders 12 (2005): 511-520.
  4. Jellinger KA and Attems J. “Cerebral amyloid angiopathy in lewy body disease”. Journal of Neural Transmission 3 (2008): 473-482.
  5. De Reuck J., et al. “Prevalence of cerebrovascular lesions in patients with Lewy body dementia: a neuropathological study”. Clinical Neurology and Neurosurgery 7 (2013): 1094-1097.
  6. Hansen D., et al. “Review: Clinical, neuropathological and genetic features of Lewy body dementias”. Neuropathology and Applied Neurobiology 7 (2019): 635-654.
  7. De Reuck J. “Histopathological stainings and definitions of vascular disruptions in the elderly brain”. Experimental Gerontology 47 (2012): 834-837.
  8. Adler CH., et al. “Unified staging system for Lewy body disorders: Clinicopathological correlations and comparison to Braak staging”. Journal of Neuropathology and Experimental Neurology 10 (2019): 891-899.
  9. Love S., et al. “Development, appraisal, validation and implementation of a consensus protocol for assessment of cerebral amyloidal angiopathy in post-mortem brain tissue”. American Journal of Neurodegenerative Disease 3 (2014): 19-32.
  10. Scheltens P., et al. “Atrophy of medial temporal lobes on MRI in “probable” Alzheimer’s disease and normal aging: diagnostic value and neuropsychological correlates”. Journal of Neurology, Neurosurgery, and Psychiatry 10 (1992): 967-972.
  11. Wahlund LO., et al. “Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging: a comparative study”. Journal of Neurology, Neurosurgery, and Psychiatry 5 (2000): 630-635.
  12. De Reuck J., et al. “Cerebrovascular lesions during normal aging: A neuropathological study with 7.0-tesla magnetic resonance imaging”. EC Neurology3 (2018): 229-235.
  13. De Reuck J., et al. “Comparison of 7.0-T T2*-magnetic resonance imaging of cerebral bleeds in post-mortem brain sections of Alzheimer patients with their neuropathological correlates”. Cerebrovascular Diseases 31 (2011): 511-517.
  14. Hansen D., et al. “Novel clinicopathological characteristics differentiate dementia with Lewy bodies from Parkinson, disease dementia”. Neuropathology and Applied Neurobiology (2020): 27.
  15. Wu E., et al. “Amyloid angiopathy in diffuse Lewy body disease”. Neurology11 (1992): 2131-2135.
  16. De Reuck J., et al. “Post-mortem 7.0-tesla magnetic resonance study of cortical microinfarcts in neurodegenerative diseases and vascular dementia with neuropathological correlates”. Journal of the Neurological Sciences 1-2 (2014): 85-89.
  17. Gungor I., et al. “Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer’s disease”. Parkinsonism and Related Disorders 9 (2015): 1101-1104.
  18. De Reuck J., et al. “Detection of cortical microbleeds in posmortem brains of patients with Lewy body dementia; A 7-0 tesla magnetic resonance imaging study with neuropathological correlates”. European Neurology 3-4 (2015): 158-161.
  19. Olichney JM., et al. “The apolipoprotein E epsilon 4 allele is associated with increased neuretic plaques and cerebral amyloid angiopathy in Alzheimer’s disease and Lewy body variant”. Neurology1 (1996): 190-196.
  20. Garcia-Segura ME., et al. “APOE 4/4 is associated with aberrant motor behaviour through both Lewy body and cerebral amyloid angiopathy pathology in high Alzheimer’s disease pathological load”. Journal of Alzheimer's Disease 4 (2019): 1077-1087.
Citation: Jacques De Reuck., et al. “Comparison of Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Lewy Body Dementia Brains with and without Cerebral Amyloid Angiopathy”. EC Neurology 12.11 (2020): 17-21.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

December Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the December issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 20, 2021.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to