Research Article
Volume 12 Issue 10 - 2020
Cerebellar and Polysymptomatic Onset as Long Term Disability Factors in Mexican Multiple Sclerosis Patients
Ricardo Jorge García-Bermúdez, Alejandra Calderón-Vallejo, Raúl Carrera-Pineda and Brenda Bertado-Cortés*
Department of Neurology, Mexican Social Security Institute, Mexico City, Mexico
*Corresponding Author: Brenda Bertado-Cortés, Department of Neurology, Mexican Social Security Institute, Mexico City, Mexico..
Received: September 21, 2020; Published: September 30, 2020




Abstract

Introduction: Multiple sclerosis is one of the main causes of disability in young people. Multiple factors have been related with poor prognosis, including onset relapse. In Mexican population there are no studies about onset relapse and prognosis in multiple sclerosis.

Materials and Methods: We analyzed demographic and clinical characteristics of patients with multiple sclerosis diagnosis during hospitalization between January 2017 to December 2019, at Specialities Hospital of “Siglo XXI” National Medical Center, in Mexico city, Mexico, with a six months follow up and disability evaluation by EDSS. We performed chi squared of relapse onsets and smoking and the risk of developing an EDSS of 2.5 or higher (median EDSS of our population).

Results and Discussion: 75 patients were diagnosed with multiple sclerosis, but only 73 completed the six months follow up. By six months follow up, the RR for EDSS of 2.5 or higher in patients with cerebellar onset was 1.01 (p = 0.687) and for polysymptomatic onset 0.29 (p = 0.141). Motor onset had a RR of 2.46 (p = 0.027) and smoking patients had a RR of 2.89 (p = 0.007). Unlike other studies, in Mexican populations with multiple sclerosis cerebellar and polysymptomatic onset are not risk factors for a greater disability while motor onset and smoking have a similar risk with other populations.

Conclusion: Cerebellar and polysymptomatic onset are not risk factors for long term disability in our population, while motor onset and smoking are risk factors.

Keywords: Multiple Sclerosis; Cerebellar Onset; Polysymptomatic Onset; Smoking; Disability; Prognosis

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Citation: Brenda Bertado-Cortés., et al. “Cerebellar and Polysymptomatic Onset as Long Term Disability Factors in Mexican Multiple Sclerosis Patients”. EC Neurology 12.10 (2020): 81-85.

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