Research Article
Volume 12 Issue 10 - 2020
The Mechanism of Tumor Progression Inhibition by Verapamil-Hydrochloride in the Long-Term Period after Complex Therapy in Patients with Glioblastomas
N YA Gridina1*, O YA Glavatsky1, AN Morozov1, YU V Ushenin2, LA Kot1, NG Draguntsova1, AD Belousova1, OI Korolyova1 and IV Boltina3
1The State Institution, “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyіv, Ukraine
2Institute of Semiconductor Physics, V. E. Lashkaryova, Kyіv, Ukraine
3Institute of Ecohygiene and Toxicology, L. I Medvedya, Kyіv, Ukraine
*Corresponding Author: N YA Gridina, The State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyіv, Ukraine.
Received: August 13, 2020; Published: September 30, 2020




Abstract

The paper presents preliminary results of verapamil- hydrochloride use in the treatment of glioblastomas after radiation and chemotherapy, including courses of treatment with temozolomide and lomustine. After the end of the courses with lomustine treatment, followed by continuous treatment with verapamil - hydrochloride at low concentrations, the result of the patient’s life expectancy for a period of 35 months was presented as a case-report after surgical removal of glioblastoma. Relapse after surgery occurred 29 months later. Patients treated with temozolomide and verapamil-hydrochloride showed a life expectancy result that did not differ from the literature data. It has been hypothesized about the reasons for the increase in life expectancy when using lomustine with verapamil-hydrochloride. The latter at low concentrations does not have a direct cytotoxic effect on glioblastoma cells, but it helps to inhibit the growth of their recurrence. It was shown that an increase in the degree of malignancy of gliomas coincides with an increase in the manifestations of tumor-associated inflammation, as well as an increase in the number of chromosomal aberrations and aneuploidy in peripheral blood lymphocytes. Studies carried out on blood culture have shown that verapamil- hydrochloride helps to stabilize the blood cell genome. After the course of treatment with lomustine, which has a more prolonged cytotoxic effect on blood cells than temozolomide, verapamil manages to stabilize their genome to a greater extent due to an increase in the level of transmembrane potential, which ultimately leads to a decrease in inflammation and prevents the early appearance of glioblastoma relapses.

Keywords: Glioblastoma Cells; Temozolomide; Lomustine; Verapamil-Hydrochloride; Low Concentration

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Citation: N YA Gridina., et al. “The Mechanism of Tumor Progression Inhibition by Verapamil-Hydrochloride in the Long-Term Period after Complex Therapy in Patients with Glioblastomas”. EC Neurology 12.10 (2020): 58-65.

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