Review Article
Volume 12 Issue 10 - 2020
Convergence in Motor Nerve Diseases: Relating ALS Etiology to Diagnosis in MND Mimics
Denis Larrivee1,2*
1Mind and Brain Institute, Loyola University Chicago, USA
2Arts and Sciences, University of Navarra Medical School, Spain
*Corresponding Author: Denis Larrivee, Mind and Brain Institute, Loyola University Chicago, USA and Arts and Sciences, University of Navarra Medical School, Spain.
Received: September 07, 2020; Published: September 19, 2020




Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive, paralytic disorder characterized by degeneration of motor neurons in the brain and spinal cord, with the eventual atrophy of most muscles, including those of the diaphragm. Among the motor nerve diseases (MNDs), ALS is the most common, amounting to 80% of cases, and has an overall prevalence of about 1 to 9 cases per 100,000 across the globe. Research into the etiological factors contributing to the disease has shown that multiple factors are causative for ALS, with three major domains of cellular processes - RNA and protein processing and homeostasis, cytoskeletal mechanics, and neuroinflammation - among the predominant factors discovered to date. Conversely, much less is known of the non-ALS MNDs, which variously mimic ALS symptoms, anatomical targeting and disease progression. Based on their resemblance and recent discoveries of shared causative mechanisms, knowledge of their etiology and degenerative events could benefit from ALS findings, which can be expected to be mutually beneficial for ALS diagnosis and therapy. Accordingly, this paper presents current genetic, mechanistic, and biomarker findings of shared dysfunctions of ALS and the non ALS MNDs, illustrating a number of converging mechanisms that could be targeted to assess prognosis and therapeutic intervention.

Keywords: Motor Nerve Diseases; Amyotrophic Lateral Sclerosis; Spinal Muscular Atrophy; ASC 1 Complex; Primary Lateral Sclerosis; Biomarkers; Neurofilament Protein

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Citation: Denis Larrivee. “Convergence in Motor Nerve Diseases: Relating ALS Etiology to Diagnosis in MND Mimics”. EC Neurology 12.10 (2020): 26-36.

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