Research Article
Volume 12 Issue 9 - 2020
The Correlation between the Neurological Complications of Rheumatoid Arthritis with the Disease Activity and Functional Impairment (Disability) in Omdurman - Khartoum in 2015
Mohammed I Alfaki1*, Mohamed D Dafaalla1, Eltoum HAA3, Mohamed Adel Taha1, Mohamed A Abdelrahim1, Musaab M Alfaki1, Razeen Alhabeeb Alsherif1, Mohamed A Alnour1, Dina N Osman1 and Abbashar M Hussein2
1Daoud Research Group, Khartoum, Sudan
2Department of Neurology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
3Department of Rheumatology, Omdurman University Hospital, Omdurman, Sudan
*Corresponding Author: Mohammed I Alfaki, Daoud Research Group, Khartoum, Sudan.
Received: May 20, 2020; Published: August 26, 2020


Objectives: To identify the impact and predictors of the neurological complications of rheumatoid arthritis (RA) among Sudanese patients.

Methodology: A case series study of 58 consecutive patients diagnosed as having RA at Omdurman teaching hospital rheumatology clinic was done. Patients have another possible etiology for the neurological manifestations were excluded. The doctors of rheumatology clinic examined the patients and the Clinical Disease Activity Index (CDAI) was calculated. A senior consultant neurologist objectively assessed the neurological complications of RA. The patients were interviewed using the Health Assessment Questionnaire (HAQ) to evaluate the functional impairment. Various statistical tests were used to assess any possible association between various variables obtained.

Results: Almost 60% have neurological signs (pyramidal system signs 43.1%, proximal weakness 8.6%, sensorimotor neuropathy 5.2%, pure sensory neuropathy 1.7%, extrapyramidal/cerebellar 0%). The mean HAQ scores for patients who express neurological signs and those who don’t express are 1.34 and 1.40 respectively without significant difference (P = 0.778). The association between the neurological complications and disease activity, ESR value, and rheumatoid factor status is not significant (P = 0.701, 0.515, 0.299 respectively). There is not only a strong association between the disease activity (CDAI) of RA and functional status (HAQ) of the patient (P = 0.0, R = 0.56), but also 30% of variability of the functional impairment can be attributed exclusively to the variability of the disease activity (R2 = 0.3).

Conclusion: The RA activity is the major determinant of disease morbidity. The functional impairment caused by the neurological complications is negligible.

The disease activity, ESR value, and rheumatoid factor status are poor predictors of the neurologic complications.

Keywords: Rheumatoid Arthritis; Neurological Complications; Disease Activity; Functional Impairment (Disability); Sudan


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Citation: Mohammed I Alfaki., et al. “The Correlation between the Neurological Complications of Rheumatoid Arthritis with the Disease Activity and Functional Impairment (Disability) in Omdurman - Khartoum in 2015”. EC Neurology 12.8 (2020): 66-75.

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