Research Article
Volume 12 Issue 9 - 2020
Increased MKK3 Correlates with GSK3A and P38 Concentrations in Children with Autism
AJ Russo1*, Albert Mensah2 and Judith Bowman2
1Retired Visiting Assistant Professor of Biology, Drew University, Madison, NJ and Research Director, Mensah Medical Center, Warrenville, Il, USA
2Mensah Medical Center, Warrenville, Il, USA
*Corresponding Author: AJ Russo, Retired Visiting Assistant Professor of Biology, Drew University, Madison, NJ and Research Director, Mensah Medical Center, Warrenville, Il, USA.
Received: June 24, 2020; Published: August 10, 2020




Abstract

GSK3A (Glycogen synthase kinase 3-alpha), MKK3 (mitogen-activated protein kinase kinase 3) and P38 (P38 mitogen-activated protein kinases) all function in glucose metabolism. GSK3 acting upon glycogen synthase. MKK3 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase P38 and P38 regulates the expression of GLUT (glucose transporter). In this study we measured the concentration of MKK3, P38 and Insulin in an autistic group and controls and compared these concentrations to GSK3A and the concentrations of each other. We found that, like GSK3A, MKK3 is significantly higher in the autistic group and MKK3 levels correlate significantly with the GSK3A levels. We also found that Both MKK3 and GSK3A concentrations correlated significantly with P38 levels in these patients. These results support a role for glucose membrane transport dysfunction in the etiology of autism.

Keywords: GSK3A (Glycogen Synthase Kinase 3-Alpha); MKK3 (Mitogen-Activated Protein Kinase Kinase 3); P38 (P38 Mitogen-Activated Protein Kinases); GLUT (Glucose Transporter)

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Citation: AJ Russo., et al. “Increased MKK3 Correlates with GSK3A and P38 Concentrations in Children with Autism”. EC Neurology 12.9 (2020): 25-30.

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