Review Article
Volume 12 Issue 8 - 2020
Bipolar Disorder: Diagnosis, Pathophysiology and Therapy
Agrim Jain*
Department of Clinical Research, School of Biological and Biomedical Sciences, Galgotias University, Greater Noida, UP, India
*Corresponding Author: Agrim Jain, Department of Clinical Research, School of Biological and Biomedical Sciences, Galgotias University, Greater Noida, UP, India.
Received: May 29, 2020; Published: July 23, 2020


Bipolar disorder is a mental illness that causes dramatic shifts in a person’s mood, energy and ability to think clearly. People with bipolar experience high and low moods-known as mania and depression-which differ from the typical ups-and-downs most people experience. People often undergo lack of energy to sometimes their energy levels touching the zenith. The person is sometimes in the feeling of sudden guilt and sometimes in the feeling of inflated self-esteem.

There are various symptoms that can be observed in a person and can be noted in order to diagnose the bipolar disorder in a person. Certain depression episodes prolong stress or anxiety, mania and hypomania can lead to bipolar disorder. The various neurological disorders can also be responsible for the cause of the disease. The neurotransmitter imbalance is one of the major causes of the bipolar disorder. Other major causes are the genetic and environmental factors which also lead to the formation of this syndrome in a person.

The need of absolute and perfect medication for the bipolar disorder is the foremost priority. No research or study could find out the exact treatment for the bipolar disorder. Treatment is usually lifelong and often involves a combination of medications and psychotherapy.

Keywords: Bipolar Disorder; Stress; Mania; Hypomania; Depression; Catechol-O-methyltransferase


  1. MW Jann. “Diagnosis and treatment of bipolar disorders in adults: A review of the evidence on pharmacologic treatments”. American Health and Drug Benefits 7.9 (2014): 489-499.
  2. J Tiihonen., et al. “Real-world effectiveness of antipsychotic treatments in a nationwide cohort of 29 823 patients with schizophrenia”. JAMA Psychiatry 74.7 (2017): 686-693.
  3. R Cooper. “Diagnostic and statistical manual of mental disorders (DSM)”. Knowledge Organization (2017).
  4. B Pavlova., et al. “Lifetime prevalence of anxiety disorders in people with bipolar disorder: A systematic review and meta-analysis”. The Lancet Psychiatry 2.8 (2015): 710-717.
  5. E Brietzke., et al. “A theoretical framework informing research about the role of stress in the pathophysiology of bipolar disorder”. Progress in Neuro-Psychopharmacology and Biological Psychiatry (2012).
  6. A Caspi., et al. “Influence of life stress on depression”. Science 80 (2003): 386-389.
  7. JS Manning. “Tools to improve differential diagnosis of bipolar disorder in primary care”. The Primary Care Companion to The Journal of Clinical Psychiatry 12.1 (2010): 17-22.
  8. AM Kilbourne., et al. “Burden of general medical conditions among individuals with bipolar disorder”. Bipolar Disorders 6.5 (2004): 368-373.
  9. F Benazzi. “Bipolar II disorder: Epidemiology, diagnosis and management”. CNS Drugs 21.9 (2007): 727-740.
  10. E Vieta., et al. “A European perspective on the Canadian guidelines for bipolar disorder”. Bipolar Disorders 7.3 (2005): 73-76.
  11. CL Bowden., et al. “Practice guideline for the treatment of patients with bipolar disorder (revision)”. American Journal of Psychiatry 159.4 (2002): 1-50.
  12. RMA Hirschfeld., et al. “Perceptions and impact of bipolar disorder: How far have we really come? Results of the National Depressive and Manic-Depressive Association 2000 Survey of individuals with bipolar disorder”. Journal of Clinical Psychiatry 64.2 (2003): 161-174.
  13. R Hunter., et al. “Bipolar disorder - Aetiology and pathophysiology”. Hospital Pharmacist (2004).
  14. JM Gill., et al. “Using electronic health record-based tools to screen for bipolar disorder in primary care patients with depression”. Journal of the American Board of Family Medicine 25.3 (2012): 283-290.
  15. MW Jann. “Implications for atypical antipsychotics in the treatment of schizophrenia: Neurocognition effects and a neuroprotective hypothesis”. Pharmacotherapy 24.12 (2004): 1759-1783.
  16. P McGuffin., et al. “The heritability of bipolar affective disorder and the genetic relationship to unipolar depression”. Archives of General Psychiatry 60.5 (2003): 497-502.
  17. DJ Miklowitz and SL Johnson. “The Psychopathology and Treatment of Bipolar Disorder”. Annual Review of Clinical Psychology 2 (2006): 199.
  18. S Hodgins., et al. “Children of parents with bipolar disorder: A population at high risk for major affective disorders”. Child and Adolescent Psychiatric Clinics of North America 11.3 (2002): 533-553.
  19. PH Wender., et al. “Psychiatric Disorders in the Biological and Adoptive Families of Adopted Individuals With Affective Disorders”. Archives Of General Psychiatry 43.10 (1986): 923-929.
  20. W Berrettini. “Evidence for shared susceptibility in bipolar disorder and schizophrenia”. American Journal of Medical Genetics 123.1 (2003): 59-64.
  21. RM Murray., et al. “A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder”. Schizophrenia Research 71.1-2 (2004): 405-416.
  22. LJ Siever and KL Davis. “Overview: Toward a dysregulation hypothesis of depression”. American Journal of Psychiatry (1985).
  23. DS Charney., et al. “Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression”. Archives of General Psychiatry 38.10 (1981): 1160-1180.
  24. CA Stockmeier. “Involvement of serotonin in depression: Evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter”. Journal of Psychiatric Research 37.5 (2003): 357-373.
  25. A Anand., et al. “Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients”. The American Journal of Psychiatry 157.7 (2000): 1108-1114.
  26. CA Naranjo., et al. “The role of the brain reward system in depression”. Progress in Neuro-Psychopharmacology and Biological Psychiatry 25.4 (2001): 781-823.
  27. KW Sax and SM Strakowski. “Behavioral sensitization in humans”. Journal of Addictive Diseases (2001): 55-65.
  28. TE Robinson and JB Becker. “Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis”. Brain Research Reviews 396.2 (1986): 157-198.
  29. PW Kalivas., et al. “Behavioral and neurochemical effects of acute and daily cocaine administration in rats”. Journal of Pharmacology and Experimental Therapeutics 245.2 (1988): 485-492.
  30. JR Geddes and DJ Miklowitz. “Treatment of bipolar disorder”. The Lancet (2013).
  31. JR Geddes., et al. “Long-Term Lithium Therapy for Bipolar Disorder: Systematic Review and Meta-Analysis of Randomized Controlled Trials”. American Journal of Psychiatry 161.2 (2004): 247-222.
  32. LV Kessing., et al. “Valproate v. lithium in the treatment of bipolar disorder in clinical practice: Observational nationwide register-based cohort study”. British Journal of Psychiatry (2011): 57-63.
  33. DR Goldsmith., et al. “Lamotrigine: A review of its use in bipolar disorder”. Drugs 63.19 (2003): 2029-2050.
  34. F Ng., et al. “The role of lamotrigine in the management of bipolar disorder”. Neuropsychiatric Disease and Treatment 3.4 (2007): 463-474.
  35. RB Sassi., et al. “Increased gray matter volume in lithium-treated bipolar disorder patients”. Neuroscience Letters 329.2 (2002): 243-245.
  36. RA Kowatch., et al. “Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder”. Journal of the American Academy of Child and Adolescent Psychiatry 39.6 (2000): 713-720.
  37. SN Ghaemi and JJ Katzow. “The use of quetiapine for treatment-resistant bipolar disorder: A case series”. Annals of Clinical Psychiatry 11.3 (1999): 137-140.
  38. E Vieta., et al. “Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: A randomized, double-blind, placebo-controlled study”. Bipolar Disorders 9.4 (2007): 413-425.
  39. LL Davis., et al. “Divalproex in the treatment of bipolar depression: A placebo-controlled study”. Journal of Affective Disorders 85.3 (2005): 259-266.
  40. KD Denicoff., et al. “Comparative prophylactic efficacy of lithium, carbamazepine, and the combination in bipolar disorder”. The Journal of Clinical Psychiatry 58.11 (1997): 470-478.
  41. WA Nolen. “Carbamazepine, a possible adjunct or alternative to lithium in bipolar disorder”. Acta Psychiatrica Scandinavica 67.4 (1983): 218-225.
  42. A Cipriani., et al. “Olanzapine in long-term treatment for bipolar disorder”. Cochrane Database of Systematic Reviews 24.12 (2009): 1729-1738.
  43. SL McElroy., et al. “Olanzapine in treatment-resistant bipolar disorder”. Journal of Affective Disorders 49.2 (1998): 119-222.
  44. A Vasudev., et al. “Oxcarbazepine in the maintenance treatment of bipolar disorder”. Cochrane Database of Systematic Reviews (2008): CD005171.
  45. A Vasudev., et al. “Oxcarbazepine for acute affective episodes in bipolar disorder”. The Cochrane Database of Systematic Reviews (2011).
  46. P Montgomery and AJ Richardson. “Omega-3 fatty acids for bipolar disorder”. Cochrane Database of Systematic Reviews (2008).
  47. AL Stoll., et al. “Omega-3 fatty acids and bipolar disorder: A review”. Prostaglandins Leukotrienes and Essential Fatty Acids 60.5-6 (1999): 329-337.
  48. JR Calabrese., et al. “Fish oils and bipolar disorder: A promising but untested treatment”. Archives of General Psychiatry 56.5 (1999): 413-414.
  49. YS Woo., et al. “Lurasidone as a potential therapy for bipolar disorder”. Neuropsychiatric Disease and Treatment (2013): 1521-1529.
  50. RH Belmaker. “Lurasidone and bipolar disorder”. American Journal of Psychiatry (2014).
  51. MA Frye., et al. “Clozapine in bipolar disorder: Treatment implications for other atypical antipsychotics”. Journal of Affective Disorders 48.2-3 (1998): 91-104.
  52. A Ciapparelli., et al. “Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: A naturalistic 48-month follow-up study”. The Journal of Clinical Psychiatry 64.4 (2003): 451-458.
  53. S Derry and RA Andrew. “Atypical antipsychotics in bipolar disorder: Systematic review of randomised trials”. BMC Psychiatry 7 (2007): 40.
  54. KD Chang. “The use of atypical antipsychotics in pediatric bipolar disorder”. Journal of Clinical Psychiatry 4 (2008): 4-8.
  55. T Suppes., et al. “Effectiveness of the extended release formulation of quetiapine as monotherapy for the treatment of acute bipolar depression”. Journal of Affective Disorders (2010): 485-493.
  56. ME Thase., et al. “Efficacy of quetiapine monotherapy in bipolar I and II depression: A double-blind, placebo-controlled study (the BOLDER II study)”. Journal of Clinical Psychopharmacology 26.6 (2006): 600-609.
  57. E Vieta., et al. “Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: A meta-analysis of randomized controlled trials”. The International Journal of Neuropsychopharmacology 14.8 (2011): 1029-1049.
  58. CL Bowden and V Singh. “Valproate in bipolar disorder: 2000 Onwards”. Acta Psychiatrica Scandinavica 426 (2005): 13-20.
  59. CL Bowden and V Singh. “Valproate: Clinical Pharmacological Profile”. in Bipolar Psychopharmacotherapy: Caring for the Patient: Second Edition (2011).
  60. LN Yatham. “A clinical review of aripiprazole in bipolar depression and maintenance therapy of bipolar disorder”. Journal of Affective Disorders 128 (2011): 21-28.
  61. RS McIntyre. “Aripiprazole for the maintenance treatment of bipolar I disorder: A review”. Clinical Therapeutics 7 (2010): 319-323.
  62. L Warrington., et al. “Ziprasidone for the treatment of acute manic or mixed episodes associated with bipolar disorder”. CNS Drugs 21.10 (2007): 835-849.
  63. RL Findling., et al. “Efficacy, long-term safety, and tolerability of Ziprasidone in children and adolescents with bipolar disorder”. Journal of Child and Adolescent Psychopharmacology 23.8 (2013): 545-557.
  64. M Haas., et al. “Risperidone for the treatment of acute mania in children and adolescents with bipolar disorder: A randomized, double-blind, placebo-controlled study”. Bipolar Disorders 11.7 (2009): 687-700.
  65. GA Carlson., et al. “Liquid risperidone in the treatment of rages in psychiatrically hospitalized children with possible bipolar disorder”. Bipolar Disorders 12.2 (2010): 205-212.
  66. S Loganathan. “Chlorpromazine-induced skin pigmentation with short-term use in a patient with bipolar disorder: A case report [4]”. Primary Care Companion to the Journal of Clinical Psychiatry 9.4 (2007): 316-317.
  67. M Tohen., et al. “Efficacy of Olanzapine and Olanzapine-Fluoxetine Combination in the Treatment of Bipolar I Depression”. Archives Of General Psychiatry 60.11 (2003): 1079-1088.
  68. PE Keck., et al. “Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression”. The Journal of Clinical Psychiatry 66.5 (2005): 611-616.
  69. I Pacchiarotti., et al. “The International Society for bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders”. The American Journal of Psychiatry 170.11 (2013): 1249-1262.
  70. L Tondo., et al. “Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders”. Acta Psychiatrica Scandinavica 127.5 (2013): 355-364.
  71. G Vázquez., et al. “Comparison of antidepressant responses in patients with bipolar vs. unipolar depression: A meta-analytic review”. Pharmacopsychiatry 44.1 (2011): 21-26.
  72. BH Amit and A Weizman. “Antidepressant treatment for acute bipolar depression: An update”. Depression Research and Treatment (2012): 684725.
  73. KR Connolly and ME Thase. “The clinical management of bipolar disorder: A review of evidence-based guidelines”. The Primary Care Companion to The Journal of Clinical Psychiatry (2011): 10r01097.
  74. U Mccormick., et al. “Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses”. Journal of the American Association of Nurse Practitioners 27.9 (2015): 530-542.
  75. VP Kamboj. “Herbal medicine”. Current Science 78.1 (2000): 35-39.
  76. S Bent and R Ko. “Commonly used herbal medicines in the United States: A review”. American Journal of Medicine 116.7 (2004): 478-485.
  77. NJ Gogtay., et al. “The use and safety of non-allopathic Indian medicines”. Drug Safety 25.14 (2002): 1005-1019.
  78. V Gupta., et al. “Therapeutic efficacy of Phytochemicals as anti-anxiety-a review”. Journal of Pharmacy Research (2010).
  79. E Wiebe. “A randomized trial of aromatherapy to reduce anxiety before abortion”. Effective Clinical Practice 3.4 (2000): 166-169.
  80. J Edge. “A pilot study addressing the effect of aromatherapy massage on mood, anxiety and relaxation in adult mental health”. Complementary Therapies in Nursing and Midwifery 9.2 (2003): 90-97.
  81. SM Wilkinson., et al. “Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer: A multicenter randomized controlled trial”. Journal of Clinical Oncology 25.5 (2007): 532-539.
  82. D Keaton., et al. “Utilization of herbal and nutritional compounds among older adults with bipolar disorder and with major depression”. International Journal of Geriatric Psychiatry 24.10 (2009): 1087-1093.
  83. R Bauer. “Damiana”. Zeitschrift fur Phyther (2017).
  84. JH Baek., et al. “Clinical applications of herbal medicines for anxiety and insomnia; Targeting patients with bipolar disorder”. Australian and New Zealand Journal of Psychiatry (2014).
  85. S Weng., et al. “Comparison of the Addition of Siberian Ginseng (Acanthopanax senticosus) Versus Fluoxetine to Lithium for the Treatment of Bipolar Disorder in Adolescents: A Randomized, Double-Blind Trial”. Current Therapeutic Research 68.4 (2007): 280-290.
  86. JS Cauffield and HJ Forbes. “Dietary supplements used in the treatment of depression, anxiety, and sleep disorders”. Lippincott’s Primary Care Practice 3.3 (1999): 290-304.
  87. K Linde., et al. “St John’s wort for major depression”. Cochrane Database of Systematic Reviews (2008).
  88. EA Apaydin., et al. “A systematic review of St. John’s wort for major depressive disorder”. Systematic Reviews (2016).
Citation: Agrim Jain. “Bipolar Disorder: Diagnosis, Pathophysiology and Therapy”. EC Neurology 12.8 (2020): 136-149.

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