Research Article
Volume 12 Issue 7 - 2020
Relationship between Amount of Exercise and Fatigue in People with Parkinson’s Disease
RuiPing Xia*, Thomas J Ronck, Ryan A Sanft and Ross P Eason
Department of Physical Therapy, Franklin Pierce University, Goodyear, AZ, USA
*Corresponding Author: RuiPing Xia, Department of Physical Therapy, Franklin Pierce University, Goodyear, AZ, USA.
Received: June 05, 2020; Published: June 30, 2020




Abstract

Fatigue is one of the most debilitating symptoms in Parkinson’s disease (PD). It has been identified as an unmet need by the PD community due to limited understanding of fatigue. Fatigue likely not only limits patient’s participation in activity but also hinders patients’ compliance in therapy. Accumulating evidence suggests that exercise may be effective in management of PD-fatigue. The objective of this study was to examine the relationship between exercise and fatigue in individuals with PD. Further, the impact of depression and disease history on fatigue was also investigated. This was an observational, cross-sectional study. One hundred and thirty-one (131) patients participated in this survey research by filling in the Parkinson’s Fatigue Scale (PFS) and providing information about their weekly exercise duration, history of PD, and with or without a clinical depression. Pearson correlation analysis was applied to examine the relationship between weekly exercise duration expressed in 1/minute and PFS score. T-tests were performed to compare fatigue between participants with and without clinical depression as well as between participants at early and advanced stages of PD. A significant correlation was observed between the inversed weekly exercise duration (1/minute) and fatigue (r = 0.267; P = 0.02). Less fatigue was associated with increased physical activity. Further, a significant difference was found in fatigue level between patients with and without depression (P = 0.02). There was no difference in fatigue between the early and the advanced stages of PD groups (P = 0.23). The findings of this study support that an adequate amount of exercise and physical activity may be an effective approach to managing PD-fatigue and improving quality of life in individuals with PD.

Keywords: Parkinson’s Disease; Fatigue; Physical Activity; Exercise; Association

References

  1. Chaudhuri K Ray and Daniel G Healy. “Non-Motor Symptoms of Parkinson’s Disease: Diagnosis and Management”. The Lancet Neurology3 (2006): 235-245.
  2. Chaudhuri K Ray and Yogini Naidu. “Early Parkinson’s Disease and Non-Motor Issues”. Journal of Neurology 255 (2008): 33-38.
  3. Gallagher David A., et al. “What Are the Most Important Nonmotor Symptoms in Patients with Parkinson’s Disease and Are We Missing Them?” Movement Disorders: Official Journal of the Movement Disorder Society 15 (2010): 2493-2500.
  4. Friedman Joseph H., et al. “Fatigue in Parkinson’s Disease: A Review”. Movement Disorders: Official Journal of the Movement Disorder Society 3 (2007): 297-308.
  5. Fahn Stanley. “Parkinson’s Disease: 10 Years of Progress, 1997-2007”. Movement Disorders: Official Journal of the Movement Disorder Society1 (2010): S2-S14.
  6. Herlofson K and JP Larsen. “The Influence of Fatigue on Health-Related Quality of Life in Patients with Parkinson’s Disease”. Acta Neurologica Scandinavica1 (2003): 1-6.
  7. Elbers RG., et al. “Impact of Fatigue on Health-Related Quality of Life in Patients with Parkinson’s Disease: A Prospective Study”. Clinical Rehabilitation3 (2014): 300-311.
  8. Elbers RG., et al. “Interventions for Fatigue in Parkinson’ s Disease (Review)” (2015): 10.
  9. Lou Jau-Shin. “Fatigue in Parkinson’s Disease and Potential Interventions”. Neuro Rehabilitation 1 (2015): 25-34.
  10. Friedman J and H Friedman. “Fatigue in Parkinson’s Disease”. Neurology 10 (1993): 2016-2018.
  11. Barone Paolo., et al. “The PRIAMO Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson’s Disease”. Movement Disorders: Official Journal of the Movement Disorder Society 11 (2009): 1641-1649.
  12. Friedman Joseph H., et al. “Fatigue in Parkinson’s Disease: Report from a Multidisciplinary Symposium”. NPJ Parkinson’s Disease 2 (2016).
  13. Dogan Vasfiye Burcu., et al. “Independent Effect of Fatigue on Health-Related Quality of Life in Patients with Idiopathic Parkinson’s Disease”. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology12 (2015): 2221-2226.
  14. Karlsen K., et al. “Fatigue in Patients with Parkinson’s Disease”. Movement Disorders: Official Journal of the Movement Disorder Society2 (1999): 237-241.
  15. Fava Maurizio., et al. “A Cross-Sectional Study of the Prevalence of Cognitive and Physical Symptoms during Long-Term Antidepressant Treatment”. The Journal of Clinical Psychiatry11 (2006): 1754-1759.
  16. Kluger Benzi M., et al. “Fatigue and Fatigability in Neurologic Illnesses: Proposal for a Unified Taxonomy”. Neurology4 (2013): 409-416.
  17. Brown RG., et al. “The Parkinson Fatigue Scale”. Parkinsonism and Related Disorders1 (2005): 49-55.
  18. Hagell P and L Brundin. “Towards an Understanding of Fatigue in Parkinson Disease”. Journal of Neurology, Neurosurgery, and Psychiatry5 (2009): 489-492.
  19. Smith Catherine., et al. “How Does Fatigue Influence Community-Based Exercise Participation in People with Multiple Sclerosis?” Disability and Rehabilitation22-23 (2011): 2362-2371.
  20. Karpatkin Herb and Adam Rzetelny. “Effect of a Single Bout of Intermittent versus Continuous Walking on Perceptions of Fatigue in People with Multiple Sclerosis”. International Journal of MS Care3 (2012): 124-131.
  21. Kluger Benzi M., et al. “Parkinson’s Disease-Related Fatigue: A Case Definition and Recommendations for Clinical Research”. Movement Disorders: Official Journal of the Movement Disorder Society5 (2016): 625-631.
  22. Miyasaki Janis M and Benzi Kluger. “Palliative Care for Parkinson’s Disease: Has the Time Come?” Current Neurology and Neuroscience Reports5 (2015): 26.
  23. Cugusi Lucia., et al. “Effects of a Nordic Walking Program on Motor and Non-Motor Symptoms, Functional Performance and Body Composition in Patients with Parkinson’s Disease”. Neuro Rehabilitation2 (2015): 245-254.
  24. Kelly Neil A., et al. “Novel, High-Intensity Exercise Prescription Improves Muscle Mass, Mitochondrial Function, and Physical Capacity in Individuals with Parkinson’s Disease”. Journal of Applied Physiology5 (2014): 582-592.
  25. Garber Carol Ewing and Joseph H Friedman. “Effects of Fatigue on Physical Activity and Function in Patients with Parkinson’s Disease”. Neurology7 (2003): 1119-1124.
  26. Abrantes AM., et al. “Physical Activity and Neuropsychiatric Symptoms of Parkinson Disease”. Journal of Geriatric Psychiatry and Neurology 3 (2012): 138-145.
  27. Henning M., et al. “Effectiveness of Exercise on Reducing Fatigue in Parkinson’s Disease: A Systematic Review”. EC Neurology1 (2017): 12-19.
  28. Rios Romenets Silvia., et al. “Tango for Treatment of Motor and Non-Motor Manifestations in Parkinson’s Disease: A Randomized Control Study”. Complementary Therapies in Medicine2 (2015): 175-184.
  29. Uc Ergun Y., et al. “Phase I/II Randomized Trial of Aerobic Exercise in Parkinson Disease in a Community Setting”. Neurology5 (2014): 413-425.
  30. Politis Marios., et al. “Parkinson’s Disease Symptoms: The Patient’s Perspective”. Movement Disorders: Official Journal of the Movement Disorder Society11 (2010): 1646-1651.
  31. Skorvanek M., et al. “The Associations between Fatigue, Apathy, and Depression in Parkinson’s Disease”. Acta Neurologica Scandinavica2 (2015): 80-87.
  32. Schenkman M., et al. “Exercise for People in Early- or Mid-Stage Parkinson Disease: A 16-Month Randomized Controlled Trial”. Physical Therapy 11 (2012): 1395-1410.
  33. Cugusi Lucia., et al. “Effects of an Adapted Physical Activity Program on Motor and Non-Motor Functions and Quality of Life in Patients with Parkinson’s Disease”. Neuro Rehabilitation 4 (2014): 789-794.
  34. Bergen John L., et al. “Aerobic Exercise Intervention Improves Aerobic Capacity and Movement Initiation in Parkinson’s Disease Patients”. Neuro Rehabilitation2 (2002): 161-168.
  35. Chaudhuri K Ray and L Yates. “The Non-Motor Symptom Complex of Parkinson’s Disease: A Comprehensive Assessment Is Essential”. Current Neurology and Neuroscience Reports4 (2005): 275-283.
  36. Pont-Sunyer Claustre., et al. “The Onset of Nonmotor Symptoms in Parkinson’s Disease (The ONSET PDStudy)”. Movement Disorders 2 (2015): 229-237.
Citation: RuiPing Xia., et al. “Relationship between Amount of Exercise and Fatigue in People with Parkinson’s Disease”. EC Neurology 12.7 (2020): 58-66.

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