Case Series
Volume 12 Issue 7 - 2020
Serological Gap in Patients with Recurrent Stroke and Delayed Prothrombotic State Diagnosis
Farah Aleisa
Stroke Neurologist, King Fahad Specialist Hospital at Dammam, Saudi Arabia and Neurovascular Fellowship at the University of Toronto, University Health Network, Canada
*Corresponding Author: Farah Aleisa, Stroke Neurologist, King Fahad Specialist Hospital at Dammam, Saudi Arabia.
Received: May 14, 2020; Published: June 29, 2020




Abstract

Background: Patients diagnosed with ischemic stroke undergo extensive investigations to find out the cause for the vascular event, which optimizes the secondary stroke prevention. In stroke patients under age 50 without other vascular risk factors, the investigations, includes screening for inherited and acquired hypercoagulable disorders. A group of patients with recurrent thrombotic events, and persistently negative hypercogulable testing that could be classified as SN-APS (Seronegative Antiphospholipid Antibody Syndrome).

Case Report: We are reporting two young patients with recurrent ischemic stroke, embolic stroke of undetermined etiology (ESUS), underlying etiology (embolic stroke of undetermined source-ESUS) despite extensive testing including hypercoagulable screen, the aPL and the other immunological tests were done in each with delayed positive aPL test, in the first case, the patient had a recent history of acute limb ischemia strongly suggests active prothrombotic state.

Conclusion: There is debate as to whether routinely order costly additional tests in the attempt to identify those novel aPL, or to establish the diagnosis of SN-APS and start a treatment, given the potential risk of thrombosis, on the part of those who would possibly benefit from the treatment. However, to date, there is no quality evidence that can establish the benefit.

Keywords: Stroke; Thrombosis; Stroke Prevention; Risk Factors; Stroke Treatment

References

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Citation: Farah Aleisa. “Serological Gap in Patients with Recurrent Stroke and Delayed Prothrombotic State Diagnosis”. EC Neurology 12.7 (2020): 86-91.

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