Research Article
Volume 12 Issue 6 - 2020
Main Neurological Alterations due to Vitamin B12 Deficiency
Brian França dos Santos1*, Thaiane Paladino Cardoso dos Santos1, Taiane França dos Santos1, Marco Antônio Orsini Neves1, Marco Antônio Alves Azizi1, Guilherme Gomes Azizi1, Carlos Frederico Pereira Porto Alegre Rosa1, Larissa Guiotti Calixto1, Adalgiza Mafra Moreno1, Lucrécia Helena Loureiro2, Ademir Corrêa Neto Júnior3, Carlos Henrique Melo Reis4 and Marco Antonio Araújo Leite2
1Iguaçu University - UNIG, Brazil
2MECSMA/UniFOA, Brazil
3Vassouras University - USS, Brazil
4Hospital Geral de Nova Iguaçu, Brazil
5Universidade Federal Fluminense, Brazil
*Corresponding Author: Brian França dos Santos, Iguaçu University - UNIG, Brazil.
Received: April 24,, 2020; Published: May 14, 2020


Introduction: The Vitamin B12 deficiency (cobalamin) occurs due to different factors: Nutritional deficiency, inborn or acquired errors in the absorption pathways and defects in transport or metabolic pathways.

Objective: Describe the different causes of vitamin B12 deficiency and its damage to the human body, specifically neurological disorders.

Methods: Literature review on clinical aspects of vitamin B12 deficiency. 25 references were selected, published from 2009 to 2019, composed of cohort study and clinical trials, randomized clinical case studies and case control.

Results: In common sense, vegetarians are the group risk to deficiency of vitamin B12, although studies indicate a high prevalence for this deficiency in the elderly. Most cases are represented by subclinical disability. Currently, 30% to 50% are associated with food-cobalamin malabsorption. Treatment is performed intramuscularly, but there is evidence that oral replacement is also effective.

Conclusion: Because cobalamin deficiency can be confused with other pathologies, periodic laboratory tests are recommended in the elderly and patients with risk factors, even in the absence of symptoms, while for other individuals, the tests must be performed in routine exams, since the highest rate of hypovitaminosis is subclinical.

Keywords: Vitamin B12; Vitamin B12 Deficiency; Cyanocobalamin


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Citation: Brian França dos Santos., et al. “Main Neurological Alterations due to Vitamin B12 Deficiency”. EC Neurology 12.6 (2020): 27-32.

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