Volume 12 Issue 6 - 2020
Nutraceuticals for Prevention and Treatment of Neurodegenerative Diseases
Khalid Mahmood1*, Raheel Saeed2, Tasneem Naz3, M Atif Raza Cheema4 and Darakhshan Jabeen Haleem1
1Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
2Faculty of Pharmacy, Barrett Hodgson University, The Salim Habib Campus, Karachi, Pakistan
3Department of Biochemistry, Faculty of Science, University of Karachi, Karachi, Pakistan
4Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
*Corresponding Author: Khalid Mahmood, Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Received: April 16, 2020; Published: May 13, 2020

Due to their health benefits, foods and substances derived from them have been in use for centuries. Recent rise in the use of nutraceuticals is mainly because of their safety profile [1]. Nutritional psychiatry is based on the use of nutraceuticals for treatment, prevention and cure of psychiatric disorders [2]. Several evidences suggest a potential role of several food derived substances in the management of neuropsychiatric and neurodegenerative diseases [3,4]. Clinical studies also show promising therapeutic efficacy of nutraceuticals in these diseases [5]. Therefore, many researches imply that these natural substances can play a significant role in the pharmacotherapy of neurodegenerative diseases [6].


  1. Williamson Elizabeth M., et al. “Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals”. British Journal of Pharmacology6 (2020): 1227-1240.
  2. Jacka Felice N. "Nutritional psychiatry: where to next?" EBio Medicine 17 (2017): 24-29.
  3. Boccardi Virginia., et al. "Nutraceuticals in Neurodegenerative Diseases”. Nutraceuticals and Human Health: The Food-to-supplement Paradigm 23 (2020): 163.
  4. Haleem Darakhshan Jabeen and Khalid Mahmood. "Brain serotonin in high-fat diet-induced weight gain, anxiety and spatial memory in rats”. Nutritional Neuroscience (2019): 1-10.
  5. Grimmig Bethany., et al. "Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration”. Geroscience1 (2017): 19-32.
  6. Kulshreshtha Akanksha and Poonam Piplani. "Current pharmacotherapy and putative disease-modifying therapy for Alzheimer’s disease”. Neurological Sciences9 (2016): 1403-1435.
  7. Da S Hage-Melim., et al. "The Impact of Natural Compounds on the Treatment of Neurodegenerative Diseases”. Current Organic Chemistry3 (2019): 335-360.
  8. Kovacs Gabor G. "Concepts and classification of neurodegenerative diseases”. Handbook of Clinical Neurology 145 (2018): 301-307.
  9. Mattson Mark P., et al. "Intermittent metabolic switching, neuroplasticity and brain health”. Nature Reviews Neuroscience2 (2018): 63.
  10. Jucker Mathias and Lary C Walker. "Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases”. Nature Neuroscience10 (2018): 1341-1349.
  11. Borroni Edilio., et al. "Sembragiline: a novel, selective monoamine oxidase type B inhibitor for the treatment of Alzheimer’s disease”. Journal of Pharmacology and Experimental Therapeutics3 (2017): 413-423.
  12. Crippa José Alexandre S., et al. "Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?" European Archives of Psychiatry and Clinical Neuroscience1 (2019): 121-133.
  13. Chen H., et al. "Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis”. Translational Neurodegeneration1 (2015): 1.
  14. Valero Jorge., et al. "Lifestyle shapes the dialogue between environment, microglia, and adult neurogenesis”. ACS Chemical Neuroscience4 (2016): 442-453.
  15. Marín Gonzalo A and Rafael E Larraín. "Changes in behavior and plasma metabolites after tryptophan supplementation in steers”. Journal of Veterinary Behavior 32 (2019): 24-29.
  16. Deneris Evan and Patricia Gaspar. "Serotonin neuron development: shaping molecular and structural identities”. Wiley Interdisciplinary Reviews: Developmental Biology1 (2018): e301.
  17. Best J., et al. "Models of dopaminergic and serotonergic signaling”. PharmacopsychiatryS 01 (2010): S61-S66.
  18. Islam Jahidul., et al. "Simultaneous analysis of serotonin, tryptophan and tryptamine levels in common fresh fruits and vegetables in Japan using fluorescence HPLC”. Food Bioscience 13 (2016): 56-59.
  19. Haleem Darakhshan J., et al. "Inhibition of restraint-induced anorexia by injected tryptophan”. Life Sciences 14 (1998): PL205-PL212.
  20. Khaliq S., et al. "Relationship of brain tryptophan and serotonin in improving cognitive performance in rats”. Pakistan Journal of Pharmaceutical Sciences 1 (2006): 11-15.
  21. Fernstrom John D. "Large neutral amino acids: dietary effects on brain neurochemistry and function”. Amino Acids3 (2013): 419-430.
  22. Kałużna-Czaplińska Joanna., et al. "How important is tryptophan in human health?" Critical Reviews in food Science and Nutrition 1 (2019): 72-88.
  23. Mittal Rahul., et al. "Neurotransmitters: The critical modulators regulating gut–brain axis”. Journal of Cellular Physiology9 (2017): 2359-2372.
  24. Gómez-Coronado Nieves., et al. "A review of the neurobiological underpinning of comorbid substance use and mood disorders”. Journal of Affective Disorders 241 (2018): 388-401.
  25. Dragašević-Mišković Nataša., et al. "Chemical management of levodopa-induced dyskinesia in Parkinson’s disease patients”. Expert Opinion on Pharmacotherapy2 (2019): 219-230.
  26. Pavlov AN., et al. "The Research of Physicochemical Properties and Determination of Nano-L-DOPA Quality Attributes Based on PLGA Nanoparticles for the Treatment of Parkinson's Disease”. Journal of Pharmaceutical Sciences and Research 6 (2018): 1457-1460.
  27. Wan Jintang., et al. "Neuroprotective effect of several phytochemicals and its potential application in the prevention of neurodegenerative diseases”. Geriatrics 4 (2016): 29.
  28. Roman GC., et al. "Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease”. Revue Neurologique10 (2019): 724-741.
  29. Farzaei Mohammad H., et al. "Medicinal plants in neurodegenerative diseases: perspective of traditional Persian medicine”. Current Drug Metabolism5 (2018): 429-442.
  30. Ola Mohammad Shamsul., et al. "Effects of Phytochemicals on Diabetic Retino‐neuropathy”. Neuroprotective Effects of Phytochemicals in Neurological Disorders (2017): 199.
  31. Kolahdouzan Mahshad and Mazen J Hamadeh. "The neuroprotective effects of caffeine in neurodegenerative diseases”. CNS Neuroscience and Therapeutics4 (2017): 272-290.
  32. Allen Erika N., et al. "Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism”. The Journal of Nutritional Biochemistry 54 (2018): 77-86.
  33. Zhao Zhen Xiang., et al. "Capsaicin protects against oxidative insults and alleviates behavioral deficits in rats with 6-OHDA-induced Parkinson’s disease via activation of TRPV1”. Neurochemical Research12 (2017): 3431-3438.
  34. Baluchnejadmojarad Tourandokht., et al. "Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress”. Biomedicine and Pharmacotherapy 88 (2017): 754-761.
  35. Mahmood Khalid. "Fructose Consumption Decreases Bodyweight Gain, Reduces Anxiety, Modulates Spatial Memory and Increases Dopamine but Not Serotonin Metabolism”. EC Neurology 11 (2019): 551-562.
  36. Capurso, Antonio., et al. "Extra-virgin Olive Oil, the Mediterranean Diet, and Neurodegenerative Diseases”. Benefits of the Mediterranean Diet in the Elderly Patient. Springer, Cham (2018): 81-95.
  37. Norouzi Fatemeh., et al. "Memory enhancing effect of Nigella Sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment in rats”. Drug and Chemical Toxicology3 (2019): 270-279.
  38. Cheema MAR., et al. "Nootropic and Anti-anxiety Effects of Olive Oil: Relationship with Dopamine and Serotonin Metabolism”. Journal of Nutraceuticals and Food Science 1 (2018): 4.
  39. Cobourne-Duval Makini K., et al. "Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NFκB pathway signaling targets in LPS/IFNγ-activated BV-2 microglia cells”. Journal of Neuroimmunology 320 (2018): 87-97.
  40. Cheema M Atif Raza., et al. "Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats”. Nutritional Neuroscience3 (2018): 185-194.
  41. Cheema Muhammad Atif Raza., et al. "Need of Clinical Studies on the Efficacy of Nutraceuticals for Treating Brain Disorders”. Nutritional Neuroscience 1 (2017): 10.
  42. Cheema MAR., et al. "Need of Clinical and Mechanism-Based Preclinical Studies on the Efficacy of Nutraceuticals for Treating Brain Disorders”. Journal of Nutraceuticals and Food Science 1 (2018): 3.
  43. Cheema MAR., et al. "Need of Nutrigenomic Studies for the Prevention and Treatment of Mood and Neurodegenerative Disorders”. Food and Nutrition 1 (2018):106.
Citation: Mahmood., et al. “Nutraceuticals for Prevention and Treatment of Neurodegenerative Diseases”. EC Neurology”. EC Neurology 12.6 (2020): 08-12.

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